TCTP/TPT1 Protein, Human (HEK293, His)
TCTP/TPT1 is a multifunctional protein that plays a crucial role in cellular processes by participating in calcium binding and contributing to microtubule stabilization. As a negative regulator, it destabilizes TSC22D1, thereby inhibiting apoptosis. TCTP/TPT1 Protein, Human (HEK293, His) is the recombinant human-derived TCTP/TPT1 protein, expressed by HEK293 , with N-10*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
TCTP/TPT1 is a multifunctional protein that plays a crucial role in cellular processes by participating in calcium binding and contributing to microtubule stabilization. As a negative regulator, it destabilizes TSC22D1, thereby inhibiting apoptosis. TCTP/TPT1 Protein, Human (HEK293, His) is the recombinant human-derived TCTP/TPT1 protein, expressed by HEK293 , with N-10*His labeled tag.
Background
TCTP/TPT1, a multifaceted protein, assumes a crucial role in diverse cellular processes. It engages in calcium binding and contributes to microtubule stabilization, indicating its significance in maintaining cellular structure and function. Moreover, TCTP/TPT1 acts as a negative regulator of TSC22D1-mediated apoptosis by interacting with and destabilizing the TSC22D1 protein. The protein forms homodimers and interacts with STEAP3, suggesting its involvement in various protein-protein interactions that orchestrate cellular pathways. The interaction with TSC22D1 highlights its role in modulating apoptotic processes, emphasizing the multifunctional nature of TCTP/TPT1 in cellular homeostasis.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-10*His
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Accession
P13693 (M1-C172)
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Molecular Construction
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N-term
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10*His
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TCTP (M1-C172)
Accession # P13693 -
C-term
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Protein Length
Full Length
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Synonyms
TPT1; Histamine-Releasing Factor; Tumor Protein, Translationally-Controlled 1; P23; Fortilin; HRF; TCTP; P02; Translationally-Controlled Tumor Protein
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AA Sequence
MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGEGTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAEQIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKC
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Predicted Molecular Mass
23.2 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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