TPT1 - tumor protein, translationally-controlled 1 Gene

Also Known as HRF; p02; p23; TCTP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7178

About TPT1

Cytogenetic location: 13q14.13 Genomic coordinates (GRCh38): 13:45,333,471-45,341,183 (from NCBI)

This gene has 14 transcripts (splice variants) and 247 orthologues. Ubiquitous expression in ovary (RPKM 496.6), thyroid (RPKM 416.5) and 25 other tissues.

Summary

This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including Apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some Cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

TPT1 Products (3)

mRNA	Protein	Name
NM_001286272.2	NP_001273201.1	translationally-controlled tumor protein isoform 1
NM_001286273.2	NP_001273202.1	translationally-controlled tumor protein isoform 3
NM_003295.4	NP_003286.1	translationally-controlled tumor protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	15162379	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16730713	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	11598139	GOA
involved in response to virus	IEP IEP: Inferred from expression pattern	16548883	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15162379	GOA
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	15162379	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	15319436	GOA
located in multivesicular body	IDA IDA: Inferred from direct assay	15319436	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11598139	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	15162379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPT1 Protein Structure

TCTP

0
100
172 a.a.

Protein Preferred Names	Protein Names
translationally-controlled tumor protein	fortilin

TPT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TPT1	P13693	TUBA1C	Homo sapiens	Q9BQE3	Anti Bait CoIP	27607350
Intra	TPT1	P13693	TUBA1C	Homo sapiens	Q9BQE3	BiFC	27607350
Intra	TPT1	P13693	PRDX1	Homo sapiens	Q06830	BiFC	27607350
Intra	TPT1	P13693	PRDX1	Homo sapiens	Q06830	Anti Bait CoIP	27607350
Intra	TPT1	P13693	XRCC6	Homo sapiens	P12956	BiFC	27607350
Intra	TPT1	P13693	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	22451927
Intra	TPT1	P13693	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	27607350
Intra	TPT1	P13693	ACTB	Homo sapiens	P60709	Anti Bait CoIP	27607350
Intra	TPT1	P13693	ACTB	Homo sapiens	P60709	BiFC	27607350
Intra	TPT1	P13693	YBX1	Homo sapiens	P67809	Anti Bait CoIP	27607350
Intra	TPT1	P13693	YBX1	Homo sapiens	P67809	BiFC	27607350
Intra	TPT1	P13693	HSPA9	Homo sapiens	P38646	BiFC	27607350
Intra	TPT1	P13693	HSPA9	Homo sapiens	P38646	Anti Bait CoIP	27607350
Intra	TPT1	P13693	XRCC5	Homo sapiens	P13010	Anti Bait CoIP	22451927
Intra	TPT1	P13693	EEF1D	Homo sapiens	P29692	Y2H Array	25416956
Intra	TPT1	P13693	EEF1D	Homo sapiens	P29692	Y2H Prey Pooling	25416956
Intra	TPT1	P13693	TRIP13	Homo sapiens	Q15645	Y2H Array	25416956
Intra	TPT1	P13693	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	25416956
Intra	TPT1	P13693	TP53	Homo sapiens	P04637	Anti Bait CoIP	21081126
Intra	TPT1	P13693	TP53	Homo sapiens	P04637	Anti Tag CoIP	21081126
Intra	TPT1	P13693	TP53	Homo sapiens	P04637	Anti Bait CoIP	22451927
Intra	TPT1	P13693	EEF1D	Homo sapiens	P29692-2	Y2H Array	25416956
Intra	TPT1	P13693	TSC22D1	Homo sapiens	Q15714	Anti Bait CoIP	18325344
Intra	TPT1	P13693	TSC22D1	Homo sapiens	Q15714	Y2H	18325344

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TPT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77224	TCTP/TPT1 Protein, Human (His)	P13693 (M1-C172)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700615	TCTP/TPT1 Protein, Human	P13693 (M1-C172)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700623	TCTP/TPT1 Protein, Human (HEK293, His)	P13693 (M1-C172)	≥ 90%, as determined by reducing SDS-PAGE.

TPT1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80943	TCTP Antibody (YA038)	WB, ICC/IF, FC	Human, Mouse, Rat
HY-P80943A	TCTP Antibody (YA038)(PBS only)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Chronic Urticaria	Urticaria Chronic Chronic Spontaneous Urticaria Chronic Ordinary Urticaria
Drug Allergy	Allergy Drug Drug Allergies
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Allergic Rhinitis	Hay Fever Allergic Rhinitis, Susceptibility To ALRH Atopic Rhinitis Seasonal Allergic Rhinitis Non-Seasonal Allergic Rhinitis Perenial Allergic Rhinitis Pollenosis Rhinitis Allergic Seasonal Rhinitis, Allergic, Perennial Allergic Rhinitis, Cause Unspecified Pollinosis Pollen Allergy Allergy Nos Due To Pollen Summer Catarrh Other Seasonal Allergic Rhinitis
Rhinitis	Runny Nose
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Paraneoplastic Cerebellar Degeneration	Pcd Paraneoplastic Cerebellar Ataxia Rapidely Progressive Cerebellar Syndrome Subacute Cerebellar Degeneration
Mycetoma	Madura Foot Mycetoma Of Foot
Epithelial-Stromal Tgfbi Dystrophy
Eumycotic Mycetoma	Eumycetoma Maduromycosis Mycetoma Madura Foot Maduromycosis, Mycotic Mycotic Mycetoma Mycetoma Of Foot Eumycotic Maduromycosis Mycetoma Due To Fungal Infection
Chronic Spontaneous Urticaria	Chronic Idiopathic Urticaria
Lattice Corneal Dystrophy	Familial Amyloid Neuropathy, Finnish Type Familial Amyloid Polyneuropathy, Type V
Food Allergy	Food Hypersensitivity Food Allergies Allergy Food Food Allergen-Induced Hypersensitivity
Trichothiodystrophy 7, Nonphotosensitive	TTD7 Nonphotosensitive Trichothiodystrophy 7 Trichothiodystrophy 7, Non-Photosensitive
Pericarditis
Diabetic Macular Edema
Dermatomycosis	Dermatomycoses
Retinal Vascular Occlusion	Retinal Vasc. Occlusion Occlusion Of Retinal Vessels Retinal Obstruction
Retinal Artery Occlusion	Retina Artery Narrowing Retinal Artery Spasm Spasm Of Ophthalmic Artery Retinal Spasm Vasospasm Of Retina
Macular Retinal Edema	Macular Edema Macular Oedema Macular Retinal Oedema Macular Edema, Cystoid
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10293	PDSS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14956	TPT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18795	Tpt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22714	Pdss1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25284	Tpt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TPT1	MGD	MGI:104890
Rattus norvegicus	TPT1	RGD	RGD:621623
Felis catus	TPT1	VGNC	VGNC:102352