TEAD2 Protein, Human (Depalmitoylated, sf9, His, Strep)

TEAD2 Protein, Human (Depalmitoylated, sf9, His, Strep) is the recombinant human-derived TEAD2, expressed by sf9 insect cells , with Strep, His labeled tag.

TEAD2 is a transcription factor that plays a key role in the Hippo signaling pathway, which controls organ size and suppresses tumors by restricting proliferation and promoting apoptosis. The pathway's core involves a kinase cascade where MST1/MST2, complexed with SAV1, phosphorylates and activates LATS1/2 in complex with MOB1, leading to the phosphorylation and inactivation of the oncoproteins YAP1 and WWTR1/TAZ. TEAD2 mediates the gene expression of YAP1 and WWTR1/TAZ, regulating cell proliferation, migration, and epithelial-mesenchymal transition (EMT) induction. It binds to SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and may be involved in neural development gene regulation. Additionally, TEAD2 binds to the M-CAT motif.

Human

Sf9 insect cells

Strep;His

Q15562-1 (A217-D447)

8463

Partial

AWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.