THOP1 Protein, Mouse (sf9, His)

THOP1 protein plays a key role in the metabolism of neuropeptides with less than 20 amino acids and participates in the degradation of cytoplasmic peptides. In addition to general peptide metabolism, THOP1 degrades amyloid beta precursor protein, implicating it in neurodegenerative diseases. THOP1 Protein, Mouse (sf9, His) is the recombinant mouse-derived THOP1 protein, expressed by Sf9 insect cells , with N-His labeled tag.

The THOP1 Protein plays a crucial role in the metabolism of neuropeptides under 20 amino acid residues long, participating in cytoplasmic peptide degradation. Beyond its involvement in general peptide metabolism, THOP1 exhibits the capability to degrade the amyloid-beta precursor protein, generating amyloidogenic fragments and implicating it in processes associated with neurodegenerative conditions. Additionally, THOP1 serves as a regulator in the cannabinoid signaling pathway by mediating the degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1. These diverse functions highlight THOP1's significance in the intricate network of cellular processes, from neuropeptide metabolism to regulatory roles in signaling pathways, with potential implications for neurological and signaling-related disorders.

Mouse

Sf9 insect cells

N-His

Q8C1A5 (K2-C687)

50492  [NCBI]

Partial

KPPAACAGDVVDAASPASTVNHLRWDLSAQQIRALTTQLIEQTKCVYDRVGAQNFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPCKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQEKTPKNSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLSSLEKAEDGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSSLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQLAVAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGSEAPQDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASAMLKQFLGRDPKQDAFLLSKGLQVEGSEAPAC

Approximately 75 kDa, based on SDS-PAGE under reducing conditions.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.