THOP1 Protein, Mouse (sf9, His)
THOP1 protein plays a key role in the metabolism of neuropeptides with less than 20 amino acids and participates in the degradation of cytoplasmic peptides. In addition to general peptide metabolism, THOP1 degrades amyloid beta precursor protein, implicating it in neurodegenerative diseases. THOP1 Protein, Mouse (sf9, His) is the recombinant mouse-derived THOP1 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Species: Mouse
- Source: Sf9 insect cells
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
THOP1 protein plays a key role in the metabolism of neuropeptides with less than 20 amino acids and participates in the degradation of cytoplasmic peptides. In addition to general peptide metabolism, THOP1 degrades amyloid beta precursor protein, implicating it in neurodegenerative diseases. THOP1 Protein, Mouse (sf9, His) is the recombinant mouse-derived THOP1 protein, expressed by Sf9 insect cells , with N-His labeled tag.
Background
The THOP1 Protein plays a crucial role in the metabolism of neuropeptides under 20 amino acid residues long, participating in cytoplasmic peptide degradation. Beyond its involvement in general peptide metabolism, THOP1 exhibits the capability to degrade the amyloid-beta precursor protein, generating amyloidogenic fragments and implicating it in processes associated with neurodegenerative conditions. Additionally, THOP1 serves as a regulator in the cannabinoid signaling pathway by mediating the degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1. These diverse functions highlight THOP1's significance in the intricate network of cellular processes, from neuropeptide metabolism to regulatory roles in signaling pathways, with potential implications for neurological and signaling-related disorders.
Technical Parameters
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Species Mouse
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Source Sf9 insect cells
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Tag N-His
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Accession
Q8C1A5 (K2-C687)
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Molecular Construction
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N-term
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His
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THOP1 (K2-C687)
Accession # Q8C1A5 -
C-term
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Protein Length
Full Length of Thimet oligopeptidase Chain
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Synonyms
THOP1; MP78; Thimet Oligopeptidase 1; MEPD_HUMAN; Thimet Oligopeptidase; EP24.15; Endopeptidase 24.15; TOP
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AA Sequence
KPPAACAGDVVDAASPASTVNHLRWDLSAQQIRALTTQLIEQTKCVYDRVGAQNFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPCKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQEKTPKNSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLSSLEKAEDGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSSLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQLAVAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGSEAPQDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASAMLKQFLGRDPKQDAFLLSKGLQVEGSEAPAC
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Predicted Molecular Mass
80.1 kDa
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Molecular Weight
Approximately 75 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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