TPBG/5T4 Protein, Mouse (HEK293, His)

TPBG/5T4 protein acts as an inhibitor of Wnt/β-catenin signaling, possibly by interacting indirectly with LRP6 and hindering Wnt3a-dependent LRP6 internalization. This suggests that TPBG/5T4 plays a key role in regulating the complex Wnt/β-catenin signaling pathway and influencing cellular responses related to this pathway. TPBG/5T4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TPBG/5T4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TPBG/5T4 Protein, Mouse (HEK293, His) is 330 a.a., with molecular weight of 50-70 kDa.

The TPBG/5T4 protein appears to operate as an inhibitor of Wnt/beta-catenin signaling, potentially exerting its inhibitory effects by indirectly interacting with LRP6 and impeding Wnt3a-dependent LRP6 internalization. This suggests that TPBG/5T4 may play a critical role in modulating the intricate Wnt/beta-catenin signaling pathway, influencing cellular responses and functions associated with this pathway. A comprehensive investigation into the specific molecular mechanisms underlying the interaction between TPBG/5T4 and LRP6, as well as its impact on Wnt3a-dependent LRP6 internalization, could provide valuable insights into the functional significance of TPBG/5T4 in the regulation of Wnt/beta-catenin signaling and its potential implications for cellular processes.

Mouse

HEK293

C-6*His

Q9Z0L0 (S32-S361)

21983  [NCBI]

SAPSSSVPSSSTSPAAFLASGSAQPPPAERCPAACECSEAARTVKCVNRNLLEVPADLPPYVRNLFLTGNQMTVLPAGAFARQPPLADLEALNLSGNHLKEVCAGAFEHLPGLRRLDLSHNPLTNLSAFAFAGSNASVSAPSPLEELILNHIVPPEDQRQNGSFEGMVAFEGMVAAALRSGLALRGLTRLELASNHFLFLPRDLLAQLPSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNALKVLHNSTLAEWHGLAHVKVFLDNNPWVCDCYMADMVAWLKETEVVPDKARLTCAFPEKMRNRGLLDLNSSDLDCDAVLPQSLQTS

50-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.