Tpbg - trophoblast glycoprotein Gene

Also Known as 5T4; WAIF1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21983

Summary

Acts upstream of or within several processes, including dendrite arborization; olfactory learning; and positive regulation of intracellular signal transduction. Located in several cellular components, including axon terminus; dendrite; and endoplasmic reticulum. Is expressed in several structures, including brain; epithelium; extraembryonic component; skin; and urinary system. Orthologous to human TPBG (trophoblast glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Tpbg Products (2)

mRNA Protein Name
NM_001164792.1 NP_001158264.1 trophoblast glycoprotein precursor
NM_011627.4 NP_035757.2 trophoblast glycoprotein precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell chemotaxis IMP
IMP: Inferred from mutant phenotype
20376365 MGI
acts upstream of or within dendrite arborization IMP
IMP: Inferred from mutant phenotype
22323733 MGI
acts upstream of or within mesenchymal cell migration IMP
IMP: Inferred from mutant phenotype
17507657 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
22956548 MGI
acts upstream of or within olfactory learning IMP
IMP: Inferred from mutant phenotype
27488640 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
20376365 MGI
acts upstream of or within positive regulation of chemotaxis IGI
IGI: Inferred from genetic interaction
22956548 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
22956548 MGI
acts upstream of or within positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
24613359 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
20376365 MGI
acts upstream of or within synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
27488640 MGI
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
31891182 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15977177 MGI
located in dendrite IDA
IDA: Inferred from direct assay
31891182 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15977177 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
31891182 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
20376365 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

trophoblast glycoprotein

  • 5T4 oncofetal antigen

  • 5T4 oncofetal trophoblast glycoprotein

  • 5T4 oncotrophoblast glycoprotein

  • wnt-activated inhibitory factor 1

Recombinant Tpbg Proteins

Cat. No. Product Name Accession Purity
HY-P70121 TPBG/5T4 Protein, Mouse (HEK293, His) Q9Z0L0 (S32-S361) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14925 TPBG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18049 Tpbg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24523 Tpbg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990532 Anti-TPBG Antibody Activator 96.81% Unkown
HY-P992184 Anti-5T4 scFv-Fc Antibody / Unkown
HY-P991410 5T4_0108 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpbg NCBI NCBI:7162