TPBG - trophoblast glycoprotein Gene

Also Known as 5T4; M6P1; 5T4AG; WAIF1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 7162

About TPBG

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:82,362,983-82,367,420 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele and 185 orthologues. Ubiquitous expression in esophagus (RPKM 8.0), endometrium (RPKM 5.0) and 22 other tissues.

Summary

This gene encodes a leucine-rich Transmembrane Glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

TPBG Products (3)

mRNA Protein Name
NM_001166392.2 NP_001159864.1 trophoblast glycoprotein precursor
NM_001376922.1 NP_001363851.1 trophoblast glycoprotein precursor
NM_006670.5 NP_006661.1 trophoblast glycoprotein precursor

TPBG Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (61 - 90)

LRR_8

LRR_8: Leucine rich repeat (93 - 154)

LRR_8

LRR_8: Leucine rich repeat (211 - 270)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (321 - 345)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 420 a.a.
Protein Preferred Names Protein Names

trophoblast glycoprotein

  • 5T4 oncofetal antigen

Recombinant TPBG Proteins

製品番号 製品名 アクセッション番号 純度
HY-P70512 TPBG/5T4 Protein, Human (HEK293, His) Q13641 (S32-S355) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71374 TPBG/5T4 Protein, Human (HEK293, mFc) Q13641 (S32-S355) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72421 TPBG/5T4 Protein, Human (HEK293, Avi-His) Q13641 (S32-S355) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78053 TPBG/5T4 Protein, Human (Biotinylated, HEK293, His-Avi) Q13641 (S32-S355) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700840 FITC-Labeled TPBG/5T4 Protein, Human (HEK293, His-Avi) Q13641-1 (S32-S355) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P701049 TPBG/5T4 Protein, Human (HEK293, hFc) Q13641 (S32-S355) ≥ 95%, as determined by reducing SDS-PAGE.

TPBG 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81352 5T4 Antibody (YA1097) IHC-P Human
HY-P81352A 5T4 Antibody (YA1097)(PBS only) IHC-P Human

関連疾患

Diseases Alias
Congenital Disorder Of Glycosylation, Type Il

  • Cdg Il

  • CDG1L

  • Cdgil

  • Congenital Disorder Of Glycosylation Il

  • Congenital Disorder Of Glycosylation 1l

  • Cdg-Il

  • Congenital Disorder Of Glycosylation Type Il

  • Glycosylation, Congenital Disorder Of, Type Il

  • Congenital Disorder Of Glycosylation Type 1l
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14925 TPBG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18049 Tpbg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24523 Tpbg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P990532 Anti-TPBG Antibody Activator 96.81% Unkown
HY-P992184 Anti-5T4 scFv-Fc Antibody / Unkown
HY-P991410 5T4_0108 Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris TPBG VGNC VGNC:47731
Felis catus TPBG VGNC VGNC:66469
Rattus norvegicus TPBG RGD RGD:621453
Bos taurus TPBG VGNC VGNC:36242
Mus musculus TPBG MGD MGI:1341264
Macaca mulatta TPBG VGNC VGNC:78631
Others TPBG NCBI