UBE2C Protein, Human (Sf9, His, Strep)

The UBE2C protein is a key ubiquitin-proteasome system component that acts as an E2 ubiquitin-conjugating enzyme and is the core of the covalent linkage of ubiquitin to target proteins. In vitro, UBE2C expertly promotes “Lys-11” and “Lys-48” linked polyubiquitination, demonstrating the versatility of ubiquitin chain formation. UBE2C Protein, Human (Sf9, His, Strep) is the recombinant human-derived UBE2C protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UBE2C Protein, Human (Sf9, His, Strep) is 178 a.a., .

UBE2C, a pivotal component of the ubiquitin-proteasome system, functions as an E2 ubiquitin-conjugating enzyme, playing a central role in the covalent attachment of ubiquitin to target proteins. In vitro, UBE2C demonstrates catalytic proficiency in facilitating 'Lys-11'- and 'Lys-48'-linked polyubiquitination, showcasing its versatility in ubiquitin chain formation. Crucially, UBE2C acts as an indispensable factor in the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase pivotal for governing mitotic progression. Its role in initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates underscores its significance in orchestrating the degradation of specific proteins by the proteasome, thereby promoting a timely and controlled exit from mitosis.

Human

Sf9 insect cells

N-Strep;N-8*His

O00762 (A2-P179)

11065

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.