UDG Protein, E.coli (His)
UDG Protein, an uracil-DNA glycosylase, plays a pivotal role in DNA repair by excising uracil residues, addressing misincorporation or deamination-induced uracil. This activity is crucial for genomic integrity, preventing mutagenesis. UDG's precision in recognizing and excising uracil underscores its significance in cellular DNA repair mechanisms and fidelity. UDG Protein, E.coli (His) is the recombinant E. coli-derived UDG protein, expressed by E. coli , with His labeled tag. UDG Protein, E.coli (His), has molecular weight of ~25.7 kDa.
- Species: E.coli
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
UDG Protein, an uracil-DNA glycosylase, plays a pivotal role in DNA repair by excising uracil residues, addressing misincorporation or deamination-induced uracil. This activity is crucial for genomic integrity, preventing mutagenesis. UDG's precision in recognizing and excising uracil underscores its significance in cellular DNA repair mechanisms and fidelity. UDG Protein, E.coli (His) is the recombinant E. coli-derived UDG protein, expressed by E. coli , with His labeled tag. UDG Protein, E.coli (His), has molecular weight of ~25.7 kDa.
Background
UDG protein functions as an uracil-DNA glycosylase, playing a pivotal role in the repair of DNA by excising uracil residues that may arise from the misincorporation of dUMP residues by DNA polymerase or through the deamination of cytosine. This enzymatic activity is crucial for maintaining genomic integrity by addressing instances of uracil mispairing in DNA, which, if left uncorrected, could lead to mutagenesis and other deleterious consequences. UDG's precision in recognizing and excising uracil residues underscores its significance in the cellular mechanisms dedicated to DNA repair and fidelity.
Technical Parameters
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Species E.coli
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Source E. coli
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Tag His
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Accession
P12295 (M1-E229)
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Gene ID947067 [NCBI]
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Protein Length
Full Length
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Synonyms
UNG; Uracil DNA Glycosylase; DGU; UNG1; UDG; Uracil-DNA Glycosylase; HIGM4; UNG2; Uracil-DNA Glycosylase 1,Uracil-DNA Glycosylase 2; UNG15; Uncharacterized Protein DKFZp781L1143; DKFZp781L1143; HIGM5
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AA Sequence
MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGVTIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGIAIPPSLLNMYKELENTIPGFTRPNHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRHHVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQRGETPIDWMPVLPAESE
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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