UDG Protein, E.coli (His)
UDG Protein, an uracil-DNA glycosylase, plays a pivotal role in DNA repair by excising uracil residues, addressing misincorporation or deamination-induced uracil. This activity is crucial for genomic integrity, preventing mutagenesis. UDG's precision in recognizing and excising uracil underscores its significance in cellular DNA repair mechanisms and fidelity. UDG Protein, E.coli (His) is the recombinant E. coli-derived UDG protein, expressed by E. coli , with His labeled tag. UDG Protein, E.coli (His), has molecular weight of ~25.7 kDa.
- Species: E.coli
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
UDG Protein, an uracil-DNA glycosylase, plays a pivotal role in DNA repair by excising uracil residues, addressing misincorporation or deamination-induced uracil. This activity is crucial for genomic integrity, preventing mutagenesis. UDG's precision in recognizing and excising uracil underscores its significance in cellular DNA repair mechanisms and fidelity. UDG Protein, E.coli (His) is the recombinant E. coli-derived UDG protein, expressed by E. coli , with His labeled tag. UDG Protein, E.coli (His), has molecular weight of ~25.7 kDa.
UDG protein functions as an uracil-DNA glycosylase, playing a pivotal role in the repair of DNA by excising uracil residues that may arise from the misincorporation of dUMP residues by DNA polymerase or through the deamination of cytosine. This enzymatic activity is crucial for maintaining genomic integrity by addressing instances of uracil mispairing in DNA, which, if left uncorrected, could lead to mutagenesis and other deleterious consequences. UDG's precision in recognizing and excising uracil residues underscores its significance in the cellular mechanisms dedicated to DNA repair and fidelity.
Technical Parameters
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Species E.coli
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Source E. coli
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Tag His
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Accession
P12295 (M1-E229)
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Gene ID947067 [NCBI]
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Protein Length
Full Length
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AA Sequence
MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGVTIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGIAIPPSLLNMYKELENTIPGFTRPNHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRHHVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQRGETPIDWMPVLPAESE
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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