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  4. ULBP2/NKG2DL2 Protein, Human (HEK293, hFc)

ULBP2/NKG2DL2 Protein, Human (HEK293, hFc)

Cat. No.: HY-P701055
Handling Instructions

NKG2DL2 Protein activates KLRK1/NKG2D receptor, promoting natural killer cell cytotoxicity. Importantly, it does not bind beta2-microglobulin, confirmed by research findings. ULBP2/NKG2DL2 Protein, Human (HEK293, hFc) is the recombinant human-derived ULBP2/NKG2DL2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ULBP2/NKG2DL2 Protein, Human (HEK293, hFc) is 191 a.a., with molecular weight of 55-65 kDa.

For research use only. We do not sell to patients.

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Description

NKG2DL2 Protein activates KLRK1/NKG2D receptor, promoting natural killer cell cytotoxicity. Importantly, it does not bind beta2-microglobulin, confirmed by research findings. ULBP2/NKG2DL2 Protein, Human (HEK293, hFc) is the recombinant human-derived ULBP2/NKG2DL2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ULBP2/NKG2DL2 Protein, Human (HEK293, hFc) is 191 a.a., with molecular weight of 55-65 kDa.
Background

The NKG2DL2 protein functions by binding to and activating the KLRK1/NKG2D receptor, thereby facilitating natural killer cell cytotoxicity. Its interaction with KLRK1/NKG2D has been documented. Notably, this protein does not exhibit binding affinity to beta2-microglobulin, as indicated by research findings.
Species

Human
Source

HEK293
Tag

C-hFc
Accession

Q9BZM5 (G26-S216)
Gene ID
Molecular Construction
N-term
ULBP2 (G26-S216)
Accession # Q9BZM5
hFc
C-term
Synonyms
ALCAN-alpha; N2DL2; NKG2DL2; RAET1H; RAET1L; ULBP2; ULBP-2/5/6; NKG2D ligand 2
Molecular Weight

55-65 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

ULBP2/NKG2DL2 Protein, Human (HEK293, hFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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