2. Gene
  3. ULBP2 - UL16 binding protein 2 Gene

ULBP2 - UL16 binding protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha

Gene ID: 80328 | Gene type: protein coding

About ULBP2

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,942,014-149,949,235 (from NCBI)

This gene has 1 transcript (splice variant), 302 orthologues and 22 paralogues. Biased expression in esophagus (RPKM 5.0), lung (RPKM 1.3) and 11 other tissues.

Summary

This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

ULBP2 Products(1)

mRNA Protein Name
NM_025217.4 NP_079493.1 UL16-binding protein 2 preproprotein

ULBP2 Protein Structure

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (30 - 199)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

UL16-binding protein 2

NKG2D ligand 2

Recombinant ULBP2 Proteins

Cat. No. Product Name Accession Purity
HY-P71164 NKG2DL2 Protein, Human (HEK293, His) Q9BZM5 (G26-S217) ≥95%
HY-P72000 NKG2DL2 Protein, Human (HEK 293, hFc) Q9BZM5 (G26-S217) ≥95%
HY-P78226 NKG2DL2 Protein, Human (Biotinylated, HEK293, His-Avi) Q9BZM5 (G26-S217) ≥95%
HY-P78534 NKG2DL2 Protein, Human (HEK293, His-Avi) Q9BZM5 (G26-S217) ≥95%
HY-P701055 ULBP2/NKG2DL2 Protein, Human (HEK293, hFc) Q9BZM5 (G26-S216) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15449 ULBP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ULBP2 MGD MGI:1925027