Virus-Like Particles (VLPs) isotype control Protein (HEK293)

Virus-Like Particles (VLPs) isotype control Protein (HEK293) is an empty virus-like particle, self-assembled from viral envelope or capsid proteins, and serves as a VLP control. Virus-Like Particles (VLPs) isotype control Protein (HEK293) can be used as a control for products such as CD133/PROM1 Protein-VLP, Human (HEK293, His) (HY-P78732), and Claudin-3/CLDN3 Protein-VLP, Human (HEK293, His) (HY-P700472). For more information on controls for other VLP proteins, please refer to the specific protein description. Virus-Like Particles (VLPs) isotype control Protein (HEK293) is a recombinant Virus-Like Particles (VLPs) isotype control Protein expressed by HEK293^[1][2].

Virus-Like Particles (VLPs) isotype control protein is a dedicated blank control particle that does not contain target membrane antigens and is formed solely by the self-assembly of viral structural proteins. It has the same particle structure, assembly method, and expression system as functional enveloped virus-like particles (VLPs) displaying antigens, thus eliminating non-specific immune responses and non-specific antibody binding signals from the virus-like particle scaffold itself. Virus-Like Particles (VLPs) isotype control protein differs fundamentally from functional Virus-like particles (VLPs) loaded with exogenous target proteins. It contains only pure viral envelope/capsid structural proteins and does not carry any exogenous target membrane proteins, forming blank particles after assembly that do not contain the viral genome and have no infectivity. Virus-Like Particles (VLPs) isotype control protein serves as a negative control for experiments using Virus-like particles (VLPs) and is suitable for animal immunization, ELISA antibody binding detection, FACS cell experiments, and high-throughput antibody screening^[1][2].

Virus

HEK293

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Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Nooraei S, et al. Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers. J Nanobiotechnology. 2021 Feb 25;19(1):59.

  [2]. Bachmann MF, et al. Virus-like particles: a versatile and effective vaccine platform. Expert Rev Vaccines. 2025 Dec;24(1):444-456.