VSTM2A Protein, Human ( E84K, HEK293, His)

The VSTM2A protein is a key player in early white and brown preadipocyte differentiation and actively promotes adipogenesis by upregulating the transcription factor PPARG. This regulation operates in BMP4-dependent signaling pathways, highlighting the complex molecular mechanisms involved in differentiation. VSTM2A Protein, Human ( E84K, HEK293, His) is the recombinant human-derived VSTM2A protein, expressed by HEK293 , with C-6*His labeled tag and E84K mutation.

VSTM2A, a key player in the early stages of white and brown preadipocyte cell differentiation, actively contributes to adipogenic commitment by upregulating the expression of the transcription factor PPARG. This regulatory role occurs within a BMP4-dependent signaling pathway, emphasizing the intricate molecular mechanisms involved in the differentiation process. Furthermore, VSTM2A functions as a homodimer, potentially indicating its involvement in complex protein-protein interactions critical for its regulatory activities.

Human

HEK293

C-6*His

Q8TAG5-2 (S25-F244, E84K)

222008  [NCBI]

Partial

SQAKFTEFPRNVTATEGQNVEMSCAFQSGSASVYLEIQWWFLRGPEDLDPGAEGAGAQVKLLPDRDPDSDGTKISTVKVQGNDISHKLQISKVRKKDEGLYECRVTDANYGELQEHKAQAYLKVNANSHARRMQAFEASPMWLQDMKPRKNVSAAIPSSIHGSANQRTHSTSSPQVVAKIPKQSPQSGMETHFEPFILPLTNAPQKGQSYRVDRFMNGDF

Approximately 31-50 kDa, based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.