ZYX Protein, Human (HEK293, His)
Based on 1 Customer Validation
ZYX protein is a focal adhesion protein that binds α-actin and CRP to target TES and ENA/VASP to focal adhesions to form actin-rich structures. It may play a crucial role in adhesion-stimulated gene expression. ZYX Protein, Human (HEK293, His) is the recombinant human-derived ZYX protein, expressed by HEK293 , with N-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
ZYX protein is a focal adhesion protein that binds α-actin and CRP to target TES and ENA/VASP to focal adhesions to form actin-rich structures. It may play a crucial role in adhesion-stimulated gene expression. ZYX Protein, Human (HEK293, His) is the recombinant human-derived ZYX protein, expressed by HEK293 , with N-6*His labeled tag.
Background
The ZYX protein functions as an adhesion plaque protein with a pivotal role in binding alpha-actinin and the CRP protein. Its significance lies in targeting TES and ENA/VASP family members to focal adhesions and contributing to the formation of actin-rich structures. ZYX may be a crucial component of a signal transduction pathway that orchestrates adhesion-stimulated changes in gene expression. Notably, it interacts with the HPV type 6 protein E6, while showing limited interaction with E6 proteins from HPV types 11, 16, or 18. The Pro-rich regions of ZYX engage in interactions with the EVH1 domains of ENAH, EVL, and VASP, and it also interacts with the first LIM domain of TES, NEBL (isoform 2), and SYNPO2, underscoring its diverse molecular associations and its role in mediating cellular signaling events.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-6*His
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Accession
Q15942 (A2-T572)
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Molecular Construction
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N-term
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6*His
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ZYX (A2-T572)
Accession # Q15942 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
ZYX; ESP-2; Zyxin; HED-2; Zyxin-2
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AA Sequence
AAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQT
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Predicted Molecular Mass
65.1 kDa
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Molecular Weight
Approximately 66 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (238 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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