ZYX - zyxin Gene

Also Known as ESP-2; HED-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7791

About ZYX

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,381,345-143,391,111 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 181 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 122.6), lung (RPKM 100.3) and 25 other tissues.

Summary

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin Cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

ZYX Products (3)

mRNA Protein Name
NM_001010972.2 NP_001010972.1 zyxin isoform 1
NM_001362783.2 NP_001349712.1 zyxin isoform 2
NM_003461.5 NP_003452.1 zyxin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10801818 GOA
Biological Process GO Annotation Evidence References Source
involved in integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24036928 GOA
involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
24036928 GOA
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24036928 GOA
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
8940160 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
12417594 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24036928 GOA
located in stress fiber IDA
IDA: Inferred from direct assay
18297730 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZYX Protein Structure

LIM

LIM: LIM domain (384 - 439)

LIM

LIM: LIM domain (444 - 499)

LIM

LIM: LIM domain (504 - 568)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
Protein Preferred Names Protein Names

zyxin

  • zyxin-2

ZYX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZYX Q15942 b2r9y1_human Homo sapiens B2R9Y1
Y2H Prey Pooling
25416956
Intra
ZYX Q15942 b2r9y1_human Homo sapiens B2R9Y1
Validated Y2H
25416956
Intra
ZYX Q15942 ZNF512B Homo sapiens Q96KM6
Validated Y2H
32296183
Intra
ZYX Q15942 CASS4 Homo sapiens Q9NQ75-2
Validated Y2H
32296183
Intra
ZYX Q15942 QRICH1 Homo sapiens Q2TAL8
Validated Y2H
32296183
Intra
ZYX Q15942 ENAH Homo sapiens Q8N8S7
Anti Tag CoIP
10801818
Intra
ZYX Q15942 ENAH Homo sapiens Q8N8S7
Anti Tag CoIP
33961781
Intra
ZYX Q15942 LATS1 Homo sapiens O95835
Y2H
10831611
Intra
ZYX Q15942 LATS1 Homo sapiens O95835
CoIP
10831611
Intra
ZYX Q15942 LATS1 Homo sapiens O95835
Pull Down
10831611
Intra
ZYX Q15942 EVL Homo sapiens Q9UI08-2
Validated Y2H
32296183
Intra
ZYX Q15942 EVL Homo sapiens Q9UI08-2
Complementation
32296183
Intra
ZYX Q15942 EVL Homo sapiens Q9UI08-2
Anti Tag CoIP
28514442
Intra
ZYX Q15942 RTN4IP1 Homo sapiens Q8WWV3
Validated Y2H
32296183
Intra
ZYX Q15942 PHF21A Homo sapiens Q96BD5
Y2H Array
25416956
Intra
ZYX Q15942 PHF21A Homo sapiens Q96BD5
Y2H Prey Pooling
25416956
Intra
ZYX Q15942 PHF21A Homo sapiens Q96BD5
Y2H Array
31515488
Intra
ZYX Q15942 IMP3 Homo sapiens Q9NV31
Validated Y2H
25416956
Intra
ZYX Q15942 IMP3 Homo sapiens Q9NV31
Validated Y2H
32296183
Intra
ZYX Q15942 IMP3 Homo sapiens Q9NV31
Y2H Array
25416956
Intra
ZYX Q15942 PDLIM5 Homo sapiens Q96HC4
Y2H Array
25416956
Intra
ZYX Q15942 PDLIM5 Homo sapiens Q96HC4
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZYX Proteins

Cat. No. Product Name Accession Purity
HY-P71673 ZYX Protein, Human (HEK293, His) Q15942 (A2-T572) ≥ 90%, as determined by reducing SDS-PAGE.

ZYX Antibodies

Cat. No. Product Name Application Reactivity
HY-P82714 ZYX Antibody (YA2459) WB, IHC-F, IHC-P, ICC/IF, IP Human, Rat
HY-P82714A ZYX Antibody (YA2459)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Rat

Related Diseases

Diseases Alias
Lipomatosis, Multiple

  • Lipoma

  • Familial Multiple Lipomatosis

  • Lipomatosis, Familial Multiple

  • Benign Lipomatous Tumor

  • Lipomatous Neoplasm

  • Multiple Lipomatosis

  • Fml

  • Lipo

  • Benign Tumor Of Adipose Tissue

  • Lipomatous Tumor

  • Tumor Of Adipose Tissue

  • Neoplasms, Adipose Tissue

  • Lipomas
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10

  • Arrhythmogenic Right Ventricular Dysplasia 10

  • ARVD10

  • Arrhythmogenic Right Ventricular Cardiomyopathy 10

  • Arvc10

  • Familial Arrhythmogenic Right Ventricular Dysplasia 10

  • Dysplasia, Ventricular, Right, Arrhythmogenic, Type 10
Ewing Sarcoma

  • Neuroepithelioma

  • Ewing'S Tumor

  • Primitive Neuroectodermal Tumor

  • Ewings Sarcoma

  • Ewing'S Sarcoma

  • Peripheral Neuroepithelioma

  • ES

  • Ewings Sarcoma-Primitive Neuroectodermal Tumor

  • Localized Peripheral Primitive Neuroectodermal Tumor

  • Peripheral Primitive Neuroectodermal Tumor

  • Ewing Tumor

  • Sarcoma, Ewing'S

  • Ewing Family Of Tumors

  • Extraosseous Ewing Tumor

  • Askin Tumor

  • Ewing'S Family Localized Tumor

  • Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing Sarcoma

  • Localized Ewing'S Sarcoma

  • Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing'S Tumor

  • Pnet Of Thoracopulmonary Region

  • Tumor Of The Ewing Family

  • Skeletal Ewing Sarcoma

  • Osseous Ewing Sarcoma

  • Ppnet

  • Peripheral Pnet

  • Extraskeletal Ewing Sarcoma

  • Eoe

  • Extraosseous Ewing Sarcoma

  • Extraskeletal Ewing Tumor

  • Esft

  • Ewing Sarcoma Family Of Tumors

  • Pne

  • Pnet

  • Pnet Of The Chest Wall

  • Sarcoma, Ewing

  • Neuroectodermal Tumors, Primitive, Peripheral

  • Neuroectodermal Tumor, Primitive

  • Disorder Of Eye

  • Askin'S Tumor

  • Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

  • Neuroepithelioma, Peripheral
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N12761 Penpaxilloids A Inhibitor / Unkown
HY-N19147 6-Hydroxy-8-methoxy-3-methylisocoumarin Control / Unkown
HY-RS16215 ZYX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19571 Zyx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26068 Zyx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ZYX VGNC VGNC:51838
Felis catus ZYX VGNC VGNC:67394
Mus musculus ZYX MGD MGI:103072
Bos taurus ZYX VGNC VGNC:37395
Macaca mulatta ZYX VGNC VGNC:78917
Rattus norvegicus ZYX RGD RGD:620698
Others ZYX NCBI