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  3. Drug Derivative
  4. (S)-2-Benzylpyrrolidine

(S)-2-Benzylpyrrolidine (Compound s1) serves as a METH hapten scaffold. (S)-2-Benzylpyrrolidine attenuates Methamphetamine-induced hyperlocomotion, hyperthermia and respiratory depression. (S)-2-Benzylpyrrolidine alleviates Fentanyl-induced respiratory depression.

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(S)-2-Benzylpyrrolidine

(S)-2-Benzylpyrrolidine Chemical Structure

CAS No. : 97522-31-1

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(S)-2-Benzylpyrrolidine Related Antibodies

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Description

(S)-2-Benzylpyrrolidine (Compound s1) serves as a METH hapten scaffold. (S)-2-Benzylpyrrolidine attenuates Methamphetamine-induced hyperlocomotion, hyperthermia and respiratory depression. (S)-2-Benzylpyrrolidine alleviates Fentanyl-induced respiratory depression[1].

In Vitro

(S)-2-Benzylpyrrolidine has its binding to immobilized H2-BSA inhibited by serum antibodies from H2-KLH vaccinated mice with IC50 values ranging from 3.04 μM to 4.87 μM across 1st, 2nd, and 3rd bleeds[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-2-Benzylpyrrolidine Related Antibodies
In Vivo

(S)-2-Benzylpyrrolidine (2-10 mg/kg; i.p.) hydrochloride partially antagonizes Methamphetamine-induced hyperlocomotion and hyperthermia, reverses Methamphetamine-induced respiratory depression, and alleviates Fentanyl-induced respiratory depression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss Webster (female, 6 weeks old at study start)[1]
Dosage: 2 mg/kg; 5 mg/kg; 10 mg/kg
Administration: i.p.; single dose
Result: Produced locomotor activity comparable to control (no hyperlocomotion) at 2 mg/kg.
Produced dose-dependent suppression of locomotor activity (hypolocomotive effect) at 5 mg/kg and 10 mg/kg.
Significantly attenuated methamphetamine-induced hyperlocomotion when co-administered with 2 mg/kg methamphetamine at 10 mg/kg.
Induced a modest transient 0.6 °C core body temperature increase followed by a 1.5 °C drop below baseline at 10 mg/kg alone; partially reversed methamphetamine-induced hyperthermia after 75 minutes when co-administered with 10 mg/kg methamphetamine at 10 mg/kg.
Increased minute volume (respiratory rate above baseline) at 10 mg/kg alone; reversed methamphetamine-induced respiratory depression and elevated respiration above baseline when co-administered with 2 mg/kg methamphetamine at 10 mg/kg; attenuated fentanyl-induced respiratory suppression, partially restoring normal respiration when co-administered with 0.5 mg/kg fentanyl at 10 mg/kg.
Molecular Weight

161.24

Formula

C11H15N
CAS No.
SMILES

C([C@@H]1CCCN1)C1=CC=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S)-2-Benzylpyrrolidine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-2-Benzylpyrrolidine97522-31-1Drug DerivativeDrug derivativelocomotor activityInhibitorinhibitorinhibit

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