(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride
Based on 1 Customer Validation
(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride is an intermediate in the synthesis of L-proline derivative peptides. (S)-Benzyl pyrrolidine-2-carboxylate hydrochloride is a key raw material for the synthesis of apoptosis inhibitor protein (IAP) antagonists and SMAC mimic tripeptide fragments (Boc-MeAla-Tle-Pro-OH). (S)-Benzyl pyrrolidine-2-carboxylate hydrochloride can be used to synthesize divalent quinazoline IAP antagonists.
For research use only. We do not sell to patients.
- Purity : 99.34%
- CAS No.: 16652-71-4
- Formula: C12H16ClNO2
- Molecular Weight:241.72
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride (compound 14) can undergo an amide coupling reaction with Boc-Tle-OH in the HATU/DIPEA/DCM system to generate Boc-Tle-Pro-OBn. After de-Boc by 4M HCl/dioxane, it is coupled with Boc-MeAla-OH and finally debenzylated by H2/Pd-C to obtain tripeptide fragment 16, which is used for the synthesis of divalent quinazoline IAP antagonists[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 16652-71-4
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Appearance Solid
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Molecular Weight 241.72
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Formula C12H16ClNO2
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Color White to off-white
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SMILES
O=C(OCC1=CC=CC=C1)[C@]2([H])CCCN2.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (413.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1370 mL | 20.6851 mL | 41.3702 mL | 103.4255 mL |
| 5 mM | 0.8274 mL | 4.1370 mL | 8.2740 mL | 20.6851 mL | |
| 10 mM | 0.4137 mL | 2.0685 mL | 4.1370 mL | 10.3425 mL | |
| 15 mM | 0.2758 mL | 1.3790 mL | 2.7580 mL | 6.8950 mL | |
| 20 mM | 0.2069 mL | 1.0343 mL | 2.0685 mL | 5.1713 mL | |
| 25 mM | 0.1655 mL | 0.8274 mL | 1.6548 mL | 4.1370 mL | |
| 30 mM | 0.1379 mL | 0.6895 mL | 1.3790 mL | 3.4475 mL | |
| 40 mM | 0.1034 mL | 0.5171 mL | 1.0343 mL | 2.5856 mL | |
| 50 mM | 0.0827 mL | 0.4137 mL | 0.8274 mL | 2.0685 mL | |
| 60 mM | 0.0690 mL | 0.3448 mL | 0.6895 mL | 1.7238 mL | |
| 80 mM | 0.0517 mL | 0.2586 mL | 0.5171 mL | 1.2928 mL | |
| 100 mM | 0.0414 mL | 0.2069 mL | 0.4137 mL | 1.0343 mL |
(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride Related Classifications
HY-W012071 Related Classifications
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