(S)-p-SCN-Bn-DOTA TFA
Based on 1 Customer Validation
(S)-p-SCN-Bn-DOTA TFA is a bifunctional chelator (BFC), a macrocyclic DOTA (HY-W053583) derivative for tumor pretargeting. (S)-p-SCN-Bn-DOTA TFA can be used for the conjugation of peptides and radionuclides, such as as a linker for In-111 labeled radioimmunoconjugates (RICs) for single photon emission tomography (SPECT) and in vitro biodistribution studies.
For research use only. We do not sell to patients.
- Purity: 99.88%
- Formula: C26H34F3N5O10S
- Molecular Weight:665.64
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(S)-p-SCN-Bn-DOTA TFA forms serum-stable radioimmunoconjugates with monoclonal antibodies and radioisotopes, retains tumor cell binding activity, enables SPECT visualization of subcutaneous tumor xenografts, and shows preferential tumor uptake in mouse xenograft models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 665.64
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Formula C26H34F3N5O10S
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Color White to off-white
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SMILES
OC(CN(CCN(CCN(CCN(C1)CC(O)=O)CC(O)=O)CC(O)=O)[C@H]1CC2=CC=C(C=C2)N=C=S)=O.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (75.12 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.5023 mL | 7.5116 mL | 15.0231 mL | 37.5578 mL |
| 5 mM | 0.3005 mL | 1.5023 mL | 3.0046 mL | 7.5116 mL | |
| 10 mM | 0.1502 mL | 0.7512 mL | 1.5023 mL | 3.7558 mL | |
| 15 mM | 0.1002 mL | 0.5008 mL | 1.0015 mL | 2.5039 mL | |
| 20 mM | 0.0751 mL | 0.3756 mL | 0.7512 mL | 1.8779 mL | |
| 25 mM | 0.0601 mL | 0.3005 mL | 0.6009 mL | 1.5023 mL | |
| 30 mM | 0.0501 mL | 0.2504 mL | 0.5008 mL | 1.2519 mL | |
| 40 mM | 0.0376 mL | 0.1878 mL | 0.3756 mL | 0.9389 mL | |
| 50 mM | 0.0300 mL | 0.1502 mL | 0.3005 mL | 0.7512 mL | |
| 60 mM | 0.0250 mL | 0.1252 mL | 0.2504 mL | 0.6260 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S)-p-SCN-Bn-DOTA TFA Related Classifications
HY-156038B Related Classifications
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