2. GPCR/G Protein
  3. GLP Receptor
  4. (S)-V-0219 hydrochloride

(S)-V-0219 hydrochloride is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-1R. (S)-V-0219 hydrochloride is orally active and ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice.

For research use only. We do not sell to patients.

(S)-V-0219 hydrochloride Chemical Structure

(S)-V-0219 hydrochloride Chemical Structure

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5 mg USD 210 In-stock
10 mg USD 333 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S)-V-0219 hydrochloride:

(S)-V-0219 hydrochloride Related Antibodies

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Description

(S)-V-0219 hydrochloride is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-1R. (S)-V-0219 hydrochloride is orally active and ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice[1].

IC50 & Target

GLP-1R[1]
In Vitro

(S)-V-0219 ((S)-9) (0.1 nM) hydrochloride potentiates calcium fluxes in HEK cells stably expressing hGLP-1R[1].
(S)-V-0219 (0.1 nM) hydrochloride potentiates insulin secretion stimulated by GLP-1 in the stable human pancreatic cell line EndoC-βH1 under high glucose concentration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-V-0219 hydrochloride Related Antibodies
In Vivo

(S)-V-0219 ((S)-9) (0.04-0.2 mg/kg; i.p.) hydrochloride improves glucose handling after injection of 2 g/kg glucose in normal male Wistar rats[1].
(S)-V-0219 (0. 4 mg/kg; i.g.) hydrochloride is orally active in fatty diabetic Zucker rats[1].
(S)-V-0219 (0.1-5 μg/kg in 5 μL; i.c.v.) hydrochloride decreases feeding in 12-h fasted male Wistar rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

446.89

Formula

C20H26ClF3N4O2
Appearance

Solid

Color

White to off-white

SMILES

FC(C1=CC=C(C2=NOC(CN3C[C@H](CN4CCOCC4)CCC3)=N2)C=C1)(F)F.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (223.77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2377 mL 11.1884 mL 22.3769 mL
5 mM 0.4475 mL 2.2377 mL 4.4754 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2377 mL 11.1884 mL 22.3769 mL 55.9422 mL
5 mM 0.4475 mL 2.2377 mL 4.4754 mL 11.1884 mL
10 mM 0.2238 mL 1.1188 mL 2.2377 mL 5.5942 mL
15 mM 0.1492 mL 0.7459 mL 1.4918 mL 3.7295 mL
20 mM 0.1119 mL 0.5594 mL 1.1188 mL 2.7971 mL
25 mM 0.0895 mL 0.4475 mL 0.8951 mL 2.2377 mL
30 mM 0.0746 mL 0.3729 mL 0.7459 mL 1.8647 mL
40 mM 0.0559 mL 0.2797 mL 0.5594 mL 1.3986 mL
50 mM 0.0448 mL 0.2238 mL 0.4475 mL 1.1188 mL
60 mM 0.0373 mL 0.1865 mL 0.3729 mL 0.9324 mL
80 mM 0.0280 mL 0.1399 mL 0.2797 mL 0.6993 mL
100 mM 0.0224 mL 0.1119 mL 0.2238 mL 0.5594 mL
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(S)-V-0219 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-V-0219GLP ReceptorInhibitorinhibitorinhibit

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