(S)-V-0219
(S)-V-0219 is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (S)-V-0219 activates calcium fluxes in HEK cells stably expressing hGLP-1R. (S)-V-0219 is orally active and ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice.
At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form ((S)-V-0219 hydrochloride) usually boasts enhanced water solubility and stability.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 3031984-78-5
- Fòrmula: C20H25F3N4O2
- Peso molecular:410.43
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Other In-stock Forms of (S)-V-0219
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
GLP-1R[1]
In Vitro
(S)-V-0219 ((S)-9) (0.1 nM) potentiates calcium fluxes in HEK cells stably expressing hGLP-1R[1].
(S)-V-0219 (0.1 nM) potentiates insulin secretion stimulated by GLP-1 in the stable human pancreatic cell line EndoC-βH1 under high glucose concentration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
(S)-V-0219 (0. 4 mg/kg; i.g.) is orally active in fatty diabetic Zucker rats[1].
(S)-V-0219 (0.1-5 μg/kg in 5 μL; i.c.v.) decreases feeding in 12-h fasted male Wistar rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 3031984-78-5
-
Peso molecular 410.43
-
Fòrmula C20H25F3N4O2
-
SMILES
FC(C1=CC=C(C2=NOC(CN3C[C@H](CN4CCOCC4)CCC3)=N2)C=C1)(F)F
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-V-0219 Related Classifications
HY-143312C Related Classifications
Powered by Bioz