2. Anti-infection
  3. SARS-CoV Virus Protease
  4. SARS-CoV-2 PLpro-IN-4

SARS-CoV-2 PLpro-IN-4 is a SARS-CoV-2 papain-like protease (PLPro) inhibitor with an IC50 of 0.4 μM. SARS-CoV-2 PLpro-IN-4 binds to the S3 and S4 pockets of SARS-CoV-2 PLPro, thereby functionally inhibiting its activity. SARS-CoV-2 PLpro-IN-4 exhibits antiviral activity and can be used in research on COVID-19.

For research use only. We do not sell to patients.

SARS-CoV-2 PLpro-IN-4

SARS-CoV-2 PLpro-IN-4 Chemical Structure

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SARS-CoV-2 PLpro-IN-4 Related Antibodies

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Description

SARS-CoV-2 PLpro-IN-4 is a SARS-CoV-2 papain-like protease (PLPro) inhibitor with an IC50 of 0.4 μM. SARS-CoV-2 PLpro-IN-4 binds to the S3 and S4 pockets of SARS-CoV-2 PLPro, thereby functionally inhibiting its activity. SARS-CoV-2 PLpro-IN-4 exhibits antiviral activity and can be used in research on COVID-19[1].

In Vitro

SARS-CoV-2 PLpro-IN-4 (Compound 46) (0.01-100 μM; 26 h) inhibits SARS-CoV-2 infection in A549-ACE2 cells, with an EC50 of 0.35 μM and a CC50 of 18.9 μM[1].
SARS-CoV-2 PLpro-IN-4 (0-7 μM) exhibits only extremely low drug resistance in A549 cells passaged 9 times after SARS-CoV-2 infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2 PLpro-IN-4 Related Antibodies
Molecular Weight

497.67

Formula

C31H39N5O
SMILES

CC1=NC=CC(C2=C(C)C3=C(C=C2)CCC4(CCN(CC5=NC(N6CCN(C)CC6)=CC=C5)CC4)O3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2 PLpro-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 PLpro-IN-4SARS-CoVVirus ProteaseSARS coronavirusSARS-CoV-2lung cellsA549-ACE2 cellsA549 cellscovid-19PLProInhibitorinhibitorinhibit

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