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Art. -Nr.: HY-181262

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SARS-CoV-2 PLpro-IN-4

SARS-CoV-2 PLpro-IN-4 is a SARS-CoV-2 papain-like protease (PL^Pro) inhibitor with an IC₅₀ of 0.4 μM. SARS-CoV-2 PLpro-IN-4 binds to the S3 and S4 pockets of SARS-CoV-2 PL^Pro, thereby functionally inhibiting its activity. SARS-CoV-2 PLpro-IN-4 exhibits antiviral activity and can be used in research on COVID-19.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₁H₃₉N₅O
Molecular Weight:497.67

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

SARS-CoV-2 PLpro-IN-4 Chemical Structure

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

SARS-CoV-2 PLpro-IN-4 (Compound 46) (0.01-100 μM; 26 h) inhibits SARS-CoV-2 infection in A549-ACE2 cells, with an EC₅₀ of 0.35 μM and a CC₅₀ of 18.9 μM^[1].
SARS-CoV-2 PLpro-IN-4 (0-7 μM) exhibits only extremely low drug resistance in A549 cells passaged 9 times after SARS-CoV-2 infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 497.67
Formel C₃₁H₃₉N₅O
SMILES

CC1=NC=CC(C2=C(C)C3=C(C=C2)CCC4(CCN(CC5=NC(N6CCN(C)CC6)=CC=C5)CC4)O3)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wei Q, et al. Discovery of Fragment-Based Inhibitors of SARS-CoV-2 PLPro[J]. Journal of Medicinal Chemistry, 2026.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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