SARS-CoV-2 PLpro-IN-4
SARS-CoV-2 PLpro-IN-4 is a SARS-CoV-2 papain-like protease (PLPro) inhibitor with an IC50 of 0.4 μM. SARS-CoV-2 PLpro-IN-4 binds to the S3 and S4 pockets of SARS-CoV-2 PLPro, thereby functionally inhibiting its activity. SARS-CoV-2 PLpro-IN-4 exhibits antiviral activity and can be used in research on COVID-19.
For research use only. We do not sell to patients.
- Formula: C31H39N5O
- Molecular Weight:497.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SARS-CoV-2 PLpro-IN-4 (Compound 46) (0.01-100 μM; 26 h) inhibits SARS-CoV-2 infection in A549-ACE2 cells, with an EC50 of 0.35 μM and a CC50 of 18.9 μM[1].
SARS-CoV-2 PLpro-IN-4 (0-7 μM) exhibits only extremely low drug resistance in A549 cells passaged 9 times after SARS-CoV-2 infection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 497.67
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Formula C31H39N5O
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SMILES
CC1=NC=CC(C2=C(C)C3=C(C=C2)CCC4(CCN(CC5=NC(N6CCN(C)CC6)=CC=C5)CC4)O3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2 PLpro-IN-4 Related Classifications
HY-181262 Related Classifications
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