80 Results for "

MHC II

" in MedChemExpress (MCE) Product Catalog:
Products (80)

80 Results for "MHC II" in MCE Product Catalog:

Cat. No.: HY-P11090
CAS No.: 1273551-45-3
Target:  

MHC

Research Areas:  

Inflammation/Immunology

TpD is a chimeric T-helper epitope. TpD has a special site that cathepsin can cut. Immunization with TpD produces a strong antibody response. TpD promotes long-term CD4 immune responses in animals and humans. TpD binds well to many human MHC class II types, mainly HLA-DRB1. It also binds some other HLA alleles like DRB3, DRB4, DRB5, DP, and DQ. TpD can be used to improve the immune response of peptide vaccines .
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Cat. No.: HY-P10835
Target:  

LAG-3

Research Areas:  

Cancer

LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a Kd value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8 + T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer .
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Cat. No.: HY-P11062
CAS No.: 1415031-10-5
Synonyms: MUT30
Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

M30 peptide is an MHC class II epitope antigen that can be used in cancer nanovaccine research .
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Cat. No.: HY-157171
CAS No.: 126530-17-4
Target:  

MHC

Research Areas:  

Inflammation/Immunology

Ac-YR-NH2 is a small molecule modulator of MHC class II antigen presentation. Ac-YR-NH2 can influence peptide binding by MHC II to influence immune response .
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Cat. No.: HY-P10441
CAS No.: 1240687-76-6
Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

S-palm P0(180-199) is a polypeptide that increases MHC Class II limiting reactions. S-palm P0(180-199) can be used to establish a model of chronic inflammatory demyelinating multiple radiculopathy (CIDP) .
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Cat. No.: HY-157280
CAS No.: 307320-40-7
Target:  

MHC

Research Areas:  

Inflammation/Immunology

AdCaPy is an MHC II antigen loading catalyst that accelerates the loading of peptide antigens by MHC II. AdCaPy is a useful molecular tool for enhancing immune responses .
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Cat. No.: HY-P10246
CAS No.: 139644-18-1
Target:  

MHC

Research Areas:  

Inflammation/Immunology

Hemoglobin 64-76 is a T cell inducing determinant, that binds to two different MHC class II molecules in distinct registers and lengths .
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Cat. No.: HY-P3639
CAS No.: 320341-56-8
Target:  

TNF Receptor

Research Areas:  

Others

SYLQDSVPDSFQD, anchor-modified for high-affinity binding to DR4, is a DR4-restricted MHC class II peptide Tyrosinase .
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Cat. No.: HY-P1826A
Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology Cancer

CLIP (86-100) TFA is amino acids 86 to 100 fragment of class II-associated invariant chain peptide (CLIP). CLIP is a small self-peptide and cleavage product of the invariant chain that resides in the HLA-II antigen binding groove and is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site .
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Cat. No.: HY-105488
CAS No.: 142130-73-2
Target:  

TNF Receptor MHC

Research Areas:  

Inflammation/Immunology

MDL 201112 is a carbocyclic nucleoside. MDL 201112 can decrease TNF-α production and inhibit MHC class II Ia+ antigen expression. MDL 201112 can be used for the research of inflammation and immunology .
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Cat. No.: HY-120794
CAS No.: 182134-00-5
Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

SC 67655 is a potent and stable pentapeptide MHC class II haplotype DR4 (DR4 Dw4 or DRB 1"0401) ligand with an IC50 of 50 nM. SC 67655 can be used for the study of autoimmune diseases .
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Cat. No.: HY-P10382
Target:  

MHC

Research Areas:  

Inflammation/Immunology

M133 peptide is a coronavirus-specific CD4 T cell epitope. M133 peptide is immunodominant in mice infected with the neurotropic coronavirus (the JHM strain of mouse hepatitis virus). M133 peptide forms a complex with MHC II molecules, which is recognized by specific TCRs, thereby activating CD4 T cells .
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Cat. No.: HY-W179151
CAS No.: 105026-81-1
Target:  

Dopamine Receptor

Research Areas:  

Inflammation/Immunology

N-Octanoyl dopamine is superior to dopamine in protecting graft contractile function when administered to the heart transplant recipients from brain-dead donors. N-Octanoyl dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells .
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Cat. No.: HY-P2507
CAS No.: 508230-31-7
Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

NY-ESO-1 (87-111) is a pan-MHC class II-restricted peptide sequence. NY-ESO-1 (87-111) binds to multiple HLA-DR and HLA-DP4 molecules, and stimulates Th1-type and Th-2/Th0-type CD4 + T cells when presented in the context of HLA-DR and HLA-DP4 molecules .
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Cat. No.: HY-P10525
CAS No.: 167278-49-1
Target:  

Inhibitory Antibodies

Research Areas:  

Neurological Disease

MBP Ac1-9 (4Y) is a synthetic peptide derived from a fragment of myelin basic protein (MBP) that has undergone specific chemical modifications. MBP Ac1-9 (4Y) is able to form a complex with the MHC class II molecule I-Au and activate specific T cell receptor (TCR), thus playing a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). MBP Ac1-9 (4Y) can be used to study autoimmune diseases, especially those involving the central nervous system, such as multiple sclerosis .
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Cat. No.: HY-W016773S
CAS No.: 347841-78-5
1,10-Decanediol-d20 is the deuterium labeled 1,10-Decanediol . 1,10-Decanediol is a diol compound that can react with α-ketoglutarate (aKG) to generate polymeric microparticles (termed paKG MPs) for the sustained release of aKG, thereby promoting immunosuppressive regulation. Additionally, paKG MPs can bind to dendritic cells (DCs), reducing their glycolysis and mitochondrial respiration in vitro. These metabolic changes lead to the modulation of MHC-II and CD86 expression in DCs and alter the frequency of regulatory T cells (Tregs) as well as T-helper type 1/2/17 cells in vitro. 1,10-Decanediol can be used in research within the field of immunometabolism. can be used as a surfactant/stabilizer in the synthesis of nanomaterials .
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Cat. No.: HY-168384
CAS No.: 875158-73-9
M04 is an agonist of STING. It induces the expression of the IFN reporter gene in HEK293T cells expressing wild-type human STING, but does not induce this expression in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) STING variant or in mouse RAW 264.7 cells, indicating that its activity is dependent on allelic and species variations. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). At a concentration of 50 µM, M04 stimulates dendritic cells isolated from PBMCs to express the MHC class II cell surface receptor HLA-DR and co-stimulatory molecules CD40, CD80, and CD86, and also enhances their ability to activate T cells in an ex vivo assay. M04 can be used in research on inflammatory immune diseases .
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Cat. No.: HY-W387035
CAS No.: 2799-15-7
Target:  

MHC

D-α-Methyl DOPA is an inhibitor of the binding of DQ8 peptide to MHC class II molecules. D-α-Methyl DOPA occupies a pocket along the DQ8 peptide binding groove. D-α-Methyl DOPA inhibits the binding of a DQ8 peptide to an MHC class II molecule for presentation to CD4 + T cells, thereby slowing the development or progression of type 1 diabete or celiac disease .
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Cat. No.: HY-P705385
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HLA-DRA; Histocompatibility Antigen HLA-DR Alpha; Prev. HLA-DRA1; MHC Class II Antigen; HLA Class II Histocompatibility Antigen, DR Alpha Chain; HLA-DRA Protein; MHC Class II Antigen DRA; Major Histocompatibility Complex, Class II, DR Alpha; MHC Cell Surf
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P992461

Target:  

LAG-3

Research Areas:  

Cancer

SHR-1802 is a humanized anti-LAG-3 monoclonal antibody.SHR-1802 specifically binds to LAG-3 and inhibits its binding to major histocompatibility complex class II (MHC-II), fibrinogen-like protein 1 (FGL1), galectin-3, and liver sinusoidal endothelial cell lectin.SHR-1802 can be used for the research of advanced solid tumors .
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