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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
49 Results for "
PHD2
" in MedChemExpress (MCE) Product Catalog:
Products (49)
49 Results for "PHD2" in MCE Product Catalog:
Cat. No.: HY-183654
Target:
Research Areas:
Vadadustat prodrug-1 is a near-infrared activated photocaged, blood-brain barrier-permeable neuroprotective prodrug of Vadadustat (HY-101277). Vadadustat prodrug-1 masks the acidic pharmacophore of Vadadustat, and releases active Vadadustat upon irradiation at 650 nm to inhibit PHD2. Vadadustat prodrug-1 reduces cell damage, infarct volume and cerebral edema, and promotes neurological function recovery. Vadadustat prodrug-1 can be used for the research of ischemic stroke .
Cat. No.: HY-RS18812
Target:
Research Areas:
Egln1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Egln1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-101023R
CAS No.: 1187990-87-9
Research Areas:
MK-8617 (Standard) is the analytical standard of MK-8617 (HY-101023). This product is intended for research and analytical applications. MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
Cat. No.: HY-RS04212
Target:
Research Areas:
EGLN1 Human Pre-designed siRNA Set A contains three designed siRNAs for EGLN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-179647
CAS No.: 1795110-22-3
Target:
Research Areas:
ZG-2686 is a potent and selective HIF-2α agonist with an EC50 of 0.25 µM. ZG-2686 exhibits selectivity over PHD2. ZG-2686 binds to a specific internal cavity of HIF-2α, forming hydrogen bonds via structural water molecules, which stabilizes the HIF-2α/β heterodimer and enhances transcriptional activity. ZG-2686 synergizes with Vadadustat (HY-101277) to upregulate HIF-2α-dependent EPO gene expression both in vitro and in vivo. ZG-2686 can be used for the research of renal anemia .
Cat. No.: HY-P703327
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EGLN1; HPH-2; Prev. C1orf12; Hypoxia-Inducible Factor-Proline Dioxygenase; PHD2; Egl-9 Family Hypoxia-Inducible Factor 1; ZMYND6; Egl Nine Homolog 1 (C. Elegans); HIFPH2; EGL Nine (C.Elegans) Homolog 1; SM-20; HIF Prolyl Hydroxylase 2; Prolyl Hydroxylase
Species:
Human
Source:
E. coli
Cat. No.: HY-P706012
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EGLN1; HPH-2; Prev. C1orf12; Hypoxia-Inducible Factor-Proline Dioxygenase; PHD2; Egl-9 Family Hypoxia-Inducible Factor 1; ZMYND6; Egl Nine Homolog 1 (C. Elegans); HIFPH2; EGL Nine (C.Elegans) Homolog 1; SM-20; HIF Prolyl Hydroxylase 2; Prolyl Hydroxylase
Species:
Human
Source:
E. coli
Cat. No.: HY-183996
Research Areas:
PHD-1 ligand-1 (Compound 1) is a PHD-1 ligand. PHD-1 ligand-1 serves as a target protein ligand for the synthesis of PHD-1 PROTAC degraders, such as SH-26 (HY-183995). PHD-1 ligand-1 is applicable to studies on ischemia/reperfusion injury .
Cat. No.: HY-W1059094
CAS No.: 5998-89-0
Target:
Research Areas:
2-(Pyridin-2-yl) oxazole is a bis-heteroaryl compound that serves as a pharmaceutical intermediate for synthesizing active compounds, such as CP4H1 inhibitors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
