1187990-87-9
1187990-87-9
Chemical Structure
MK-8617
- CAS No.: 1187990-87-9
- Formula:C24H21N5O4
- Molecular Weight:443.45
IUPAC Name: N-(bis(4-methoxyphenyl)methyl)-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide
InChIKey: WXLPERVDMILVIF-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4
Biological Activity: MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
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MK-8617 | 99.92% | MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2. | ||||||||||||||||||||
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MK-8617 (Standard) | ≥98% | MK-8617 (Standard) is the analytical standard of MK-8617 (HY-101023). This product is intended for research and analytical applications. MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.52
HY-147029HIF1 activator-1 -
Similarity Score 0.48
HY-118232VUF8504 -
Similarity Score 0.48
HY-155988Sirtuin modulator 6 -
Similarity Score 0.47
HY-136182YM-244769 dihydrochloride -
Similarity Score 0.47
HY-107659RYM-244769 hydrochloride (Standard) -
Similarity Score 0.47
HY-136182AYM-244769 -
Similarity Score 0.47
HY-1832596,7-Dimethoxy-1,3-bis(4-methoxyphenyl)isoquinoline -
Similarity Score 0.47
HY-19914MK-1064 -
Similarity Score 0.47
HY-170885Group II intron-IN-1 -
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