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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
76 Results for "
RNA sequences
" in MedChemExpress (MCE) Product Catalog:
Products (76)
76 Results for "RNA sequences" in MCE Product Catalog:
Referencia número: HY-185989A
Target:
Áreas de investigación:
HEX-dT Phosphoramidite is a phosphoramidite reagent used in oligonucleotide synthesis to incorporate a HEX-labeled deoxythymidine into DNA or RNA sequences.
Referencia número: HY-185990
Target:
Áreas de investigación:
JOE-dT Phosphoramidite is a phosphoramidite reagent used in solid-phase oligonucleotide synthesis to incorporate a JOE-labeled deoxythymidine into DNA or RNA sequences.
Referencia número: HY-185991
Target:
Áreas de investigación:
Methylene Blue II Phosphoramidite is a phosphoramidite reagent used in solid-phase oligonucleotide synthesis to incorporate a Methylene Blue II label into DNA or RNA sequences.
Referencia número: HY-185989
Target:
Áreas de investigación:
HEX(5)-dT Phosphoramidite is a phosphoramidite reagent used in oligonucleotide synthesis to incorporate a 5-HEX-labeled deoxythymidine into DNA or RNA sequences.
Referencia número: HY-D3489
No. CAS: 1027512-13-5
Referencia número: HY-185975
Scarless CD19 CAR circular RNA (CVB3) is a circular RNA that uses CVB3 IRES to mediate scarless expression of the CD19 chimeric antigen receptor (CAR) for CAR-T cell research. This circular RNA features a scarless circularization design, eliminating the need for a linker or adapter sequence between the 5′ and 3′ ends, and achieving efficient circularization and expression without the need for optimized UTR elements.
Referencia número: HY-L005M
295 compounds
Epigenetics involves heritable phenotypic changes that occur without alterations to the underlying DNA sequence. Key mechanisms include DNA methylation, histone modifications, and regulation by small non-coding RNAs such as microRNAs. By modifying DNA, histones, or RNA—while leaving their primary sequences intact—these processes influence molecular function and regulation, thereby playing critical roles in cellular differentiation, embryonic development, gene expression control, aging, and diseases such as cancer.
MCE provide a unique collection of 295 epigenetics-related compounds. For each regulatory target and its subtype, 3 to 5 highly specific representative compounds have been retained, which can be used in epigenetic and related disease research.
Referencia número: HY-174791
The Cre-T2A-GFP mRNA is a capped and polyadenylated messenger RNA encoding a Cre recombinase with a nuclear localization sequence (NLS) and a green fluorescent protein (GFP). The incorporation of N1-Methylpseudo-UTP can reduce the immunogenicity of the resulting mRNA.
Referencia número: HY-L005
2,031 compounds
Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases.
MCE provide a unique collection of 2,031 epigenetics-related compounds that can be used in the research of the related diseases.
Referencia número: HY-148688H
Target:
Áreas de investigación:
ASO 556089 (with PS modification) sodium is the PS-modified version of ASO 556089 (HY-148688). ASO 556089 sodium is a 16 nucleotide length gapmer (3-10-3) that targets the human and mouse long non-coding RNA MALAT1, with the sequence: 5’-GmCATTmCTAATAGmCAGmC-3’ .
Referencia número: HY-147425C
Synonyms: SLN360 sodium scrambled negative control
Áreas de investigación:
Zerlasiran (SLN360) sodium scrambled negative control is the sequence scrambled negative control of Zerlasiran sodium (HY-147425A). Zerlasiran sodium is a siRNA targeting apolipoprotein A (ApoA). Zerlasiran sodium targets hepatic ApoA synthesis via RNA interference to degrade encoding mRNA. Zerlasiran sodium can be used for the research of atherosclerotic cardiovascular disease and elevated ApoA levels .
Referencia número: HY-P11686
No. CAS: 1052677-90-3
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Áreas de investigación:
Referencia número: HY-177646C
Target:
Áreas de investigación:
FAM labled Mivelsiran (ALN-APP) sodiumis a FAM labled Mivelsiran sodium. Mivelsiran sodium is an siRNA targeting the β-amyloid precursor protein (APP). Mivelsiran sodium induces sequence-specific degradation of APP mRNA via RNA interference, thereby reducing the levels of APP protein and downstream amyloid cleavage products. Mivelsiran sodium reduces β-amyloid protein levels in the brain, alleviates neuroinflammation, and attenuates microglial proliferation. Mivelsiran sodium can be used for research on early-onset Alzheimer's disease .
Referencia número: HY-185053
Cas12a mRNA is the messenger RNA encoding Cas12a. Cas12a mRNA undergoes translation-dependent degradation triggered by the anti-CRISPR protein AcrVA2, which recognizes and binds to the N-terminal polypeptide of Cas12a. AcrVA2-triggered Cas12a mRNA degradation is independent of promoter or codon sequences, requiring only the first 100 amino acids of the Cas12a polypeptide. The down-regulation of Cas12a mRNA by AcrVA2 inhibits the biosynthesis of Cas12a .
Referencia número: HY-177646D
Target:
Áreas de investigación:
Cy3 labled Mivelsiran (ALN-APP) sodium is a Cy3 labled Mivelsiran sodium. Mivelsiran sodium is an siRNA targeting the β-amyloid precursor protein (APP). Mivelsiran sodium induces sequence-specific degradation of APP mRNA via RNA interference, thereby reducing the levels of APP protein and downstream amyloid cleavage products. Mivelsiran sodium reduces β-amyloid protein levels in the brain, alleviates neuroinflammation, and attenuates microglial proliferation. Mivelsiran sodium can be used for research on early-onset Alzheimer's disease .
Referencia número: HY-P11698
No. CAS: 476667-31-9
Áreas de investigación:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
