476667-31-9
Chemical Structure
Guanidino-G-Clamp-PNA
- CAS. Nr.: 476667-31-9
- Formula:C50H46N8O12
- Molecular Weight:950.95
InChIKey: AIWBXGLHDFKUCY-UHFFFAOYSA-N
SMILES: O=C(O)CN(C(CN1C=C2OC3=C(C(OCCN/C(NC(OCC4=CC=CC=C4)=O)=N/C(OCC5=CC=CC=C5)=O)=CC=C3)NC2=NC1=O)=O)CCNC(OCC6C7=C(C8=C6C=CC=C8)C=CC=C7)=O
Biological Activity:
Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis[1][2].
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Guanidino-G-Clamp-PNA | Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis. |
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References
- [1]. Pradeep SP, et al. Enhancing RNA inhibitory activity using clamp-G-modified nucleobases. Cell Rep Phys Sci. 2024;5(8):102120. [Content Brief]
- [2]. Das A, et al. Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs. J Org Chem. 2023;88(21):15168-15175. [Content Brief]
