Cas12a mRNA

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Cas12a mRNA is the messenger RNA encoding Cas12a. Cas12a mRNA undergoes translation-dependent degradation triggered by the anti-CRISPR protein AcrVA2, which recognizes and binds to the N-terminal polypeptide of Cas12a. AcrVA2-triggered Cas12a mRNA degradation is independent of promoter or codon sequences, requiring only the first 100 amino acids of the Cas12a polypeptide. The down-regulation of Cas12a mRNA by AcrVA2 inhibits the biosynthesis of Cas12a.

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  • Pureté : 96.3%
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    -80°C

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