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Cat. No.: HY-185053

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Cas12a mRNA

Cas12a mRNA is the messenger RNA encoding Cas12a. Cas12a mRNA undergoes translation-dependent degradation triggered by the anti-CRISPR protein AcrVA2, which recognizes and binds to the N-terminal polypeptide of Cas12a. AcrVA2-triggered Cas12a mRNA degradation is independent of promoter or codon sequences, requiring only the first 100 amino acids of the Cas12a polypeptide. The down-regulation of Cas12a mRNA by AcrVA2 inhibits the biosynthesis of Cas12a.

For research use only. We do not sell to patients.

Purity: 96.3%

Storage:

-80°C

Cas12a mRNA Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

AcrVA2 interferes with Cas12a biosynthesis by recognizing conserved residues in the N-terminal polypeptide of Cas12a and triggering the degradation of its mRNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Liquid
Color Colorless to light yellow
SMILES

[Cas12a mRNA]
Shipping

Shipping with dry ice.
Storage

-80°C

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nicole D. Marino, et al. Translation-dependent downregulation of Cas12a mRNA by an anti-CRISPR protein. bioRxiv. June 21, 2023.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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