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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
907 Results for "
Inactive
" in MedChemExpress (MCE) Product Catalog:
Products (907)
907 Results for "Inactive" in MCE Product Catalog:
Cat. No.: HY-P991736
Target:
Research Areas:
Cat. No.: HY-P75519
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AKT3; V-Akt Murine Thymoma Viral Oncogene Homolog 3; AKT Serine/Threonine Kinase 3; Non-Specific Serine/Threonine Protein Kinase; PKBG; RAC-Gamma Serine/Threonine Protein Kinase; RAC-Gamma; Protein Kinase B, Gamma; PRKBG; Protein Kinase B Gamma; RAC-Gamma Serine/Threonine-Protein Kinase; Protein Kinase Akt-3; RAC-PK-Gamma; PKB-GAMMA; PKB Gamma; MPPH2; STK-2; MPPH; V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma)
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-184501
CAS No.: 486440-74-8
UE01 is an orally active, selective small-molecule modulator targeting both ULK1/ERK1/2. UE01 activates hULK1 with an EC50 of 695.30 nM and a KD of 114.3 nM for ULK1; it inhibits hERK1 with an IC50 of 179.90 nM and a KD of 114 nM for ERK1; it shows weak binding to ERK2 with a KD of 2.8 mM. UE01 induces the conformational transition of ULK1 from an inactive to an active state, enhances the phosphorylation of ULK1 Ser317 and mAtg13 Ser355, and reduces the phosphorylation of ULK1 Ser757. UE01 competitively occupies the ATP-binding pocket of ERK1, inhibits ERK1 kinase activity, and reduces the activity of the ERK1/2 signaling pathway. UE01 induces complete autophagy flux and apoptosis, upregulates Atg5, Atg7, LC3-II/LC3-I, Bax, cytochrome C (Cyt c), Cleaved-Caspase 3, Cleaved-PARP1 and E-cadherin, downregulates p62, Bcl-2, MMP-2 and MMP-9, reduces the phosphorylation of Exo70 Ser250, and promotes the proteasome-dependent degradation of Cav-1, thereby inhibiting EMT-related phenotypes and extracellular matrix degradation. UE01 can be used in studies related to triple-negative breast cancer .
Cat. No.: HY-P74257
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK1; Cell Division Protein Kinase 1; Prev. CDC2; P34 Protein Kinase; CDC28A; P34CDC2; Cell Division Cycle 2, G1 To S And G2 To M; Cell Cycle Controller CDC2; Cell Division Control Protein 2 Homolog; CDKN1; Cyclin Dependent Kinase 1; Cyclin-Dependent Kinase 1; CCNE1; Cyclin E Variant Ex7del; Prev. CCNE; Cyclin Et; G1/S-Specific Cyclin-E1; PCCNE1; Cyclin E Variant Ex5del; Cyclin E1; Cyclin Es
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P811892
Synonyms: PPIL2; Peptidylprolyl Isomerase Like 2; CYC4; Cyp-60; UBOX7; Probable Inactive Peptidyl-Prolyl Cis-Trans Isomerase-Like 2; Peptidylprolyl Isomerase (Cyclophilin)-Like 2; RING-Type E3 Ubiquitin-Protein Ligase PPIL2; Peptidyl-Prolyl Cis-Trans Isomerase-Like 2; U-Box Domain Containing 7; Cyclophilin-60; Rotamase PPIL2; HCyP-60; PPIase; RING-Type E3 Ubiquitin Transferase Isomerase-Like 2; Peptidylprolyl Cis-Trans Isomerase; Cyclophilin-Like Protein CyP-60; Cyclophilin-Like Protein Cyp-60; Cyclophilin, 60kDa; EC 2.3.2.27; EC 5.2.1.8; CYP60; Cyp60
Cat. No.: HY-P811892A
Synonyms: PPIL2; Peptidylprolyl Isomerase Like 2; CYC4; Cyp-60; UBOX7; Probable Inactive Peptidyl-Prolyl Cis-Trans Isomerase-Like 2; Peptidylprolyl Isomerase (Cyclophilin)-Like 2; RING-Type E3 Ubiquitin-Protein Ligase PPIL2; Peptidyl-Prolyl Cis-Trans Isomerase-Like 2; U-Box Domain Containing 7; Cyclophilin-60; Rotamase PPIL2; HCyP-60; PPIase; RING-Type E3 Ubiquitin Transferase Isomerase-Like 2; Peptidylprolyl Cis-Trans Isomerase; Cyclophilin-Like Protein CyP-60; Cyclophilin-Like Protein Cyp-60; Cyclophilin, 60kDa; EC 2.3.2.27; EC 5.2.1.8; CYP60; Cyp60
Cat. No.: HY-P706239
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PRKAG1; 5'-AMP-Activated Protein Kinase, Gamma-1 Subunit; Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1; AMPK Subunit Gamma-1; 5'-AMP-Activated Protein Kinase Subunit Gamma-1; AMPK Gamma-1 Chain; Protein Kinase, AMP-Activated, Gamma 1 Non-Catalytic Subunit; AMPKG; AMPK Gamma1; AMPKg; PRKAB1; AMPK; Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1; Protein Kinase, AMP-Activated, Noncatalytic, Beta-1; Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit; 5'-AMP-Activated Protein Kinase Beta-1 Subunit; 5'-AMP-Activated Protein Kinase Subunit Beta-1; AMP-Activated Protein Kinase Beta Subunit; AMPK Subunit Beta-1; AMPK Beta -1 Chain; AMPK Beta 1; HAMPKb; AMPKb; PRKAA2; AMPK Subunit Alpha-2; Prev. PRKAA; HMGCR Kinase; AMPK; AMPK2; 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2; 5'-AMP-Activated Protein Kinase, Catalytic Alpha-2 Chain; Hydroxymethylglutaryl-CoA Reductase Kinase; AMP-Activated Protein Kinase Alpha-2 Subunit Variant 2; Acetyl-CoA Carboxylase Kinase; Non-Specific Serine/Threonine Protein Kinase; AMPKa2; AMPK-Alpha-2 Chain; Protein Kinase, AMP-Activated, Alpha 2 Catalytic Subunit; AMPK Alpha 2; Protein Kinase AMP-Activated Catalytic Subunit Alpha 2; ACACA Kinase
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
