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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
907 Results for "
Inactive
" in MedChemExpress (MCE) Product Catalog:
Products (907)
907 Results for "Inactive" in MCE Product Catalog:
Cat. No.: HY-142029
CAS No.: 215996-42-2
Target:
연구분야:
(3β)-Allopregnanolone sulfate sodium is a Nav1.3 α-subunit inhibitor (IC50: 75 μM for Nav1.3 + β1; 26 μM for Nav1.3 + β3). (3β)-Allopregnanolone sulfate sodium is involved in the analgesic mechanism of Allopregnanolone. (3β)-Allopregnanolone sulfate (sodium) can be used in the research of neuropathic pain .
Target:
연구분야:
Nav1.2-IN-2 is a Nav1.2 inhibitor with a human IC50 of 0.18 μM. Nav1.2-IN-2 preferentially binds to the inactivated state of Nav1.2, reduces window current, suppresses neuronal depolarization and action potential generation. Nav1.2-IN-2 suppresses Veratridine (HY-N6691)-induced Ca 2+ influx. Nav1.2-IN-2 can be used for the research of epilepsy .
Cat. No.: HY-189471
VEGFR2/C-RAF kinase-IN-1 is a type II dual kinase inhibitor targeting VEGFR2 and C-RAF, with IC50 values of 12.22 nM and 38.04 nM, respectively. VEGFR2/C-RAF kinase-IN-1 binds VEGFR2 and CRAF in a Type-II mode and inhibits the downstream Raf-MEK-ERK signaling cascade. VEGFR2/C-RAF kinase-IN-1 induces cell cycle arrest, apoptosis, and intracellular ROS accumulation in H1299 cells, while partially inhibiting P-gp efflux function. VEGFR2/C-RAF kinase-IN-1 can be used for cancer research, such as non-small cell lung cancer and liver cancer .
Cat. No.: HY-P7729
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CA11; Carbonic Anhydrase 11; Carbonic Anhydrase 11 (Inactive); Carbonic Anhydrase XI; Carbonic Anhydrase-Related Protein 11; CA-RP II; Carbonic Anhydrase-Related Protein 2; CARP-2; CA-RP XI; CA-XI; CARPX1; CARP XI; CARP2; CA-RP; Carbonic Anhydrase-Related
Species:
Human
Source:
HEK293
Cat. No.: HY-P70891
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ERP27; Inactive Protein Disulfide-Isomerase 27; Prev. C12orf46; ER Protein 27; PDIA8; FLJ32115; Protein Disulfide Isomerase Family A, Member 8; Chromosome 12 Open Reading Frame 46; Endoplasmic Reticulum Resident Protein 27; ERp27; Endoplasmic Reticulum Pr
Species:
Human
Source:
HEK293
Cat. No.: HY-P701679
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK6; P97-MAPK; Prev. PRKM6; ERK-3; ERK3; Extracellular Signal-Regulated Kinase, P97; HsT17250; Protein Kinase, Mitogen-Activated 5; P97MAPK; Protein Kinase, Mitogen-Activated 6; Extracellular Signal-Regulated Kinase 3; MAP Kinase Isoform P97; MAP Kinase
Species:
Human
Source:
E. coli
Cat. No.: HY-P701680
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK6; P97-MAPK; Prev. PRKM6; ERK-3; ERK3; Extracellular Signal-Regulated Kinase, P97; HsT17250; Protein Kinase, Mitogen-Activated 5; P97MAPK; Protein Kinase, Mitogen-Activated 6; Extracellular Signal-Regulated Kinase 3; MAP Kinase Isoform P97; MAP Kinase
Species:
Human
Source:
E. coli
Cat. No.: HY-P701731
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPK11; Mitogen-Activated Protein Kinase P38-2; Prev. PRKM11; Stress-Activated Protein Kinase 2b; P38-2; Stress-Activated Protein Kinase-2; SAPK2; Mitogen-Activated Protein Kinase; P38Beta; P38BETA2; Mitogen-Activated Protein Kinase P38 Beta; MAPK 11; MAP
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701804
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPKAPK2; MAPKAP Kinase 2; MAPK Activated Protein Kinase 2; MAPKAP-K2; MK2; MK-2; Mitogen-Activated Protein Kinase-Activated Protein Kinase 2; MAPK-Activated Protein Kinase 2; MAP Kinase-Activated Protein Kinase 2; MAPKAPK-2
Species:
Human
Source:
E. coli
Cat. No.: HY-P701805
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPKAPK2; MAPKAP Kinase 2; MAPK Activated Protein Kinase 2; MAPKAP-K2; MK2; MK-2; Mitogen-Activated Protein Kinase-Activated Protein Kinase 2; MAPK-Activated Protein Kinase 2; MAP Kinase-Activated Protein Kinase 2; MAPKAPK-2
Species:
Human
Source:
E. coli
Cat. No.: HY-P703638
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: TSSK3; SPOGA3; STK22C; Testis-specific serine/threonine-protein kinase 3; TSK-3; TSSK-3; Testis-specific kinase 3; EC 2.7.11.1; Serine/threonine-protein kinase 22C; Testis-Specific Kinase 3; Spermiogenesis Associated 3; Testis-Specific Serine/Threonine Ki
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-111152R
CAS No.: 912798-42-6
Target:
연구분야:
ML115 (Standard) is the analytical standard of ML115 (HY-111152). This product is intended for research and analytical applications. ML115, a molecular probe of the signal transducer, is a selective STAT3 agonist, with an EC50 of 2 nM. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene. ML115 is inactive against the related STAT1, STAT5 and NF-κB anti-targets. ML115 counteracts the effects of Ginsenoside Rc (HY-N0042) on cell viability and inflammatory responses in LPS (HY-D1056)-stimulated H9c2 and RAW264.7 cells, while altering oxidative stress markers. ML115 can be used for the study of breast and prostate cancers .
Cat. No.: HY-147099
Purity: 97.8%
dTAG-47-NEG is an inactive bifunctional negative control PROTAC and also the diastereomer of dTAGV-1 (HY-145514D). dTAG-47-NEG does not reduce the level of BCL11A-FKBP12 F36V, nor does it induce the degradation of BCL11A-FKBP12 F36V, proteins tagged with FKBP12 F36V, wild-type FKBP12, FKBP12 F36V-KRAS G12V or FKBP12 F36V-EWS/FLI. dTAG-47-NEG exerts no antiproliferative effect in cancer cells .
Cat. No.: HY-18729B
CAS No.: 141968-19-6
Synonyms: NG-Nitro-D-arginine methyl ester
Target:
D-NAME (NG-Nitro-D-arginine methyl ester) is an orally active enantiomer of L-NAME (HY-18729). D-NAME inhibits Nitric oxide synthase activity in myocardium and aorta (Note: D-NAME was once classified as an inactive substance and used as a negative control in nitric oxide synthase inhibition studies), induces increases in systolic blood pressure and mean arterial blood pressure, reduces mesenteric arterial conductance, elevates the ratio of left ventricular weight to body weight, induces myocardial fibrosis, increases the cross-sectional area of aortic wall, enhances mesenteric vasodilation induced by nitrovasodilators, and releases nitric oxide via its guanidino nitro group. D-NAME has no effect on ovalbumin-induced pulmonary eosinophilia in sensitized mice. D-NAME can be used in hypertension-related research .
Cat. No.: HY-B0710S
CAS No.: 309762-22-9
Synonyms: Trimethylglycine-13C3; Carboxy-N,N,N-trimethylmethanaminium-13C3
Cat. No.: HY-B0874R
CAS No.: 67375-30-8
Synonyms: FMC 45497 (Standard); Fendona (Standard); WL 85871 (Standard)
Alpha-Cypermethrin (Standard) (FMC 45497 (Standard); Fendona (Standard); WL 85871 (Standard)) is the analytical standard of Alpha-Cypermethrin (HY-B0874). This product is intended for research and analytical applications. Alpha-Cypermethrin (FMC 45497; Fendona; WL 85871) is a type II pyrethroid insecticide. Alpha-Cypermethrin acts by delaying the inactivation of voltage-gated sodium channels, prolonging sodium tail currents, and triggering repetitive neural discharges. Alpha-Cypermethrin exhibits knockdown and lethal activity against target insects such as Musca domestica and Anopheles culicifacies. Alpha-Cypermethrin induces neurotoxicity in mammals, alters placental and fetal neurodevelopment, and causes acute mortality in fish. Alpha-Cypermethrin can be used in studies related to neurotoxicity, vector-borne diseases, and malaria .
Cat. No.: HY-W115721
CAS No.: 523-21-7
Synonyms: Sodium rhodizonate dibasic
Cat. No.: HY-P704008
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAPK1; MAPK 2; Prev. PRKM1; ERT1; Prev. PRKM2; Mitogen-Activated Protein Kinase; ERK2; Protein Tyrosine Kinase ERK2; Extracellular Signal-Regulated Kinase 2; MAP Kinase Isoform P42; P41mapk; P42MAPK; MAPK2; MAPK 1; ERK; NS13; Mitogen-Activated Protein Kin
Species:
Human
Source:
E. coli
연구분야:
2-Hydroxy atorvastatin calcium salt is an orally active OATP1B1 substrate and inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (3-hydroxy-3-methylglutaryl-coenzyme A reductase). 2-Hydroxy atorvastatin calcium salt enters cells via OATP1B1-mediated cellular uptake and inhibits de novo hepatic cholesterol synthesis. As an active metabolite of Atorvastatin (HY-B0589), 2-Hydroxy atorvastatin calcium salt contributes to the inhibitory activity against plasma HMG-CoA reductase. 2-Hydroxy atorvastatin calcium salt can be biotransformed into an inactive lactone form, which can be hydrolyzed back to its active acid form chemically or enzymatically. 2-Hydroxy atorvastatin (calcium salt) can be used in the research of hypercholesterolemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
