(3β)-Allopregnanolone sulfate sodium
Based on 1 Customer Validation
(3β)-Allopregnanolone sulfate sodium is a Nav1.3 α-subunit inhibitor (IC50: 75 μM for Nav1.3 + β1; 26 μM for Nav1.3 + β3). (3β)-Allopregnanolone sulfate sodium is involved in the analgesic mechanism of Allopregnanolone. (3β)-Allopregnanolone sulfate (sodium) can be used in the research of neuropathic pain.
For research use only. We do not sell to patients.
- Purity : 99.07%
- CAS No.: 215996-42-2
- Formula: C21H33NaO5S
- Molecular Weight:420.54
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Nav1.3 |
In Vitro
(3β)-Allopregnanolone sulfate (1-100 μmol/L; 3 min) sodium potently inhibits sodium currents in Xenopus laevis oocytes expressing Nav1.3 + β1 with an IC50 of 75 μmol/L, via mechanisms including enhanced steady-state inactivation and use-dependent block, alongside minor effects on activation[1].
(3β)-Allopregnanolone sulfate (1-100 μmol/L; 3 min) sodium potently inhibits Na+ currents in Xenopus laevis oocytes expressing Nav1.3 + β3 with an IC50 of 26 μmol/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 215996-42-2
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Appearance Solid
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Molecular Weight 420.54
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Formula C21H33NaO5S
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)OS(=O)(O[Na])=O)([H])[C@@]4([H])[C@](CC3)([C@H](CC4)C(C)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(3β)-Allopregnanolone sulfate sodium Related Classifications
HY-142029 Related Classifications
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