ERK3 Protein, Human (Inactive, L290V, His)
ERK3 Protein, an atypical MAPK, phosphorylates MAP2 and MAPKAPK5. Interacting with MAPKAPK5, ERK3/MAPK6 undergoes Ser-189 phosphorylation, facilitating MAPKAPK5 activation. Activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The complex's precise functional implications, especially in cell cycle entry, remain elusive. ERK3 Protein, Human (L290V, His) is the recombinant human-derived ERK3 protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
ERK3 Protein, an atypical MAPK, phosphorylates MAP2 and MAPKAPK5. Interacting with MAPKAPK5, ERK3/MAPK6 undergoes Ser-189 phosphorylation, facilitating MAPKAPK5 activation. Activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The complex's precise functional implications, especially in cell cycle entry, remain elusive. ERK3 Protein, Human (L290V, His) is the recombinant human-derived ERK3 protein, expressed by E. coli , with N-6*His labeled tag.
ERK3, an atypical MAPK protein, exhibits the capacity to phosphorylate microtubule-associated protein 2 (MAP2) and MAPKAPK5. The intricacies of the complex formed with MAPKAPK5 are still under scrutiny, but a series of phosphorylation events unfolds within this interaction. Upon binding with atypical MAPKAPK5, ERK3/MAPK6 undergoes phosphorylation at Ser-189, subsequently facilitating the phosphorylation and activation of MAPKAPK5. In turn, activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The precise functional implications of this complex interplay remain elusive, although it may play a role in promoting entry into the cell cycle.
Technical Parameters
-
Species Human
-
Source E. coli
-
Tag N-6*His
-
Accession
Q16659 (M9-I327, L290V)
-
Gene ID5597
-
Molecular Construction
-
N-term
-
6*His
-
ERK3 (M9-I327, L290V)
Accession # Q16659 -
C-term
-
-
Protein Length
Partial
-
Synonyms
MAPK6; P97-MAPK; Prev. PRKM6; ERK-3; ERK3; Extracellular Signal-Regulated Kinase, P97; HsT17250; Protein Kinase, Mitogen-Activated 5; P97MAPK; Protein Kinase, Mitogen-Activated 6; Extracellular Signal-Regulated Kinase 3; MAP Kinase Isoform P97; MAP Kinase
-
AA Sequence
MNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPI
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
