Search Result

Results for "

α-adrenergic receptor blocker

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (5) Chloride Channel (1) Dopamine Receptor (1) GABA Receptor (1) Phosphodiesterase (PDE) (1)
By Research Areas:	Cardiovascular Disease (5) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0799

Dihydroergotoxine mesylate Ergoloid mesylates	GABA Receptor Chloride Channel Adrenergic Receptor Dopamine Receptor Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease
Dihydroergotoxine mesylate (Ergoloid mesylates) is an *α-adrenergic* blocking agent. Dihydroergotoxine mesylate binds with high affinity to the GABA_A receptor associated Cl ^- channel. Dihydroergotoxine mesylate also interacts with central dopaminergic and serotonergic receptors. Dihydroergotoxine mesylate displays antiproliferative, antihypertensive and neuroprotective activity .Dihydroergotoxine mesylate (Ergoloid mesylates) is an *α-adrenergic* blocking agent. Dihydroergotoxine mesylate binds with high affinity to the GABA_A receptor associated Cl ^- channel. Dihydroergotoxine mesylate also interacts with central dopaminergic and serotonergic receptors. Dihydroergotoxine mesylate displays antiproliferative, antihypertensive and neuroprotective activity .

HY-119512

Ethoxomane Ethomoxane	Adrenergic Receptor	Cardiovascular Disease
Ethoxomane (Ethomoxane) is an α-adrenergic *receptor* blocker. Ethoxomane elevates the hissing threshold induced by perifornical hypothalamic stimulation in cats. Ethoxomane exhibits antihypertensive effects. Ethoxomane can be used in the research of cardiovascular and cerebrovascular diseases .

HY-183177

Zolertine	Adrenergic Receptor	Cardiovascular Disease
Zolertine is an **α-adrenergic receptor antagonist, with a pK_i** of 6.35 for rabbit α₁A-adrenergic receptor and a pK_i of 6.81 for rat α₁B-adrenergic receptor. Zolertine competitively blocks α₁D-adrenergic receptor-mediated vasoconstriction and α₁A-adrenergic receptor-mediated vasoconstriction in arteries. Zolertine can be used in the research of hypertension .

HY-180379

Pelanserin	5-HT Receptor Adrenergic Receptor	Cardiovascular Disease
Pelanserin (Compound 1) is an orally active antihypertensive agent. Pelanserin is a potent 5-HT2 receptor antagonist. Pelanserin has the ability to block the activity of α-adrenergic receptor, with its ED₅₀ being 0.03 μg/mL. Pelanserin has vasodilatory activity, with its ED₁₀₀ being 5 μg. Pelanserin exhibits antihypertensive activity in hypertensive rats and renal hypertensive dog breeds. Pelanserin can be used for research on hypertension .

HY-181635

Azapetine	Adrenergic Receptor	Cardiovascular Disease
Azapetine is an **α-adrenergic receptor antagonist, with a IC₅₀** of 0.205 μM against rat α₁-adrenergic receptors and a IC₅₀ of 1.3 μM against rat α₂-adrenergic receptors. Azapetine blocks α1/α2-adrenergic receptor-mediated contraction of blood vessels and vascular smooth muscles. Azapetine can be used for the research of peripheral vascular diseases .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

We use cookies

MedChemExpress values your privacy and your trust is important to us. We use cookies to enhance your website experience. Some cookies are necessary to run the website. Privacy and Cookie Policy

Name
Email *

	Sorry, but the email address you supplied was invalid.

α-adrenergic receptor blocker

Inhibitors & Agonists