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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
β1,6-GlcNAc
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "β1,6-GlcNAc" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-163121
CAS No.: 1096144-06-7
Research Areas:
PST3.1a is an orally active and brain-penetrant N-acetylglucosamine glycosyltransferase (MGAT5) inhibitor with a human IC50 of 2 µM. PST3.1a inhibits TGFβR and FAK signaling pathway activity. PST3.1a alters β1,6-GlcNAc N-glycans and microtubule/microfilament integrity, increases OLIG2 expression, and inhibits proliferation, migration, invasiveness, and clonogenic capacities of glioblastoma initiating cells. PST3.1a reduces invasive and proliferative capacity of glioblastoma initiating cells in orthotopic graft models, increases overall survival of orthotopic graft model mice. PST3.1a blunts MGAT5 overexpression, decreases renal fibrosis via collagen 1, collagen 4, and galectin 3 downregulation in a rat chronic kidney disease model. PST3.1a can be used for the research of glioblastoma multiforme and chronic kidney disease .
Cat. No.: HY-P4752
CAS No.: 2022974-40-7
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Cat. No.: HY-P3795
CAS No.: 361443-81-4
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Cat. No.: HY-E70286
CAS No.: 83588-90-3
Synonyms: MGAT4B
Target:
Research Areas:
N-Acetylglucosaminyltransferase V (MGAT4B) is the enzyme that catalyzes the formation of the β1,6-GlcNAc branch of N-glycans in the Golgi apparatus using UDP-GlcNAc as the donor substrate. N-Acetylglucosaminyltransferase V is involved in cancer malignancy and autoimmune disease etiology .
Cat. No.: HY-P10572
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
