361443-81-4
Chemical Structure
G2-Peptide
- CAS No.: 361443-81-4
- Formula:C90H155N13O54
- Molecular Weight:2283.25
IUPAC Name: 1-methoxy-4-(methyl-d3)benzene-2,3,5,6-d4
InChIKey: SUFZXARNDACTNQ-XHSQKUEPSA-N
SMILES: CC(N[C@H]([C@H]([C@@H]([C@H](O1)CO)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO)O)[C@@H]1O[C@@H]3[C@H](O[C@@H]([C@H]([C@@H]3O)O)CO)O[C@@H]4[C@@H]([C@@H](O[C@@H]([C@H]4O)CO[C@@H]5[C@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O[C@@H]7O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O)CO)O)NC(C)=O)O[C@@H]8[C@H](O[C@H]([C@@H]([C@H]8O)NC(C)=O)O[C@@H]9[C@H](O[C@H]([C@@H]([C@H]9O)NC(C)=O)NC(C[C@H](NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](N)CCCCN)=O)=O)=O)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)[C@H](O)C)=O)=O)=O)CO)CO)O)=O
Biological Activity: G2-Peptide is a 3-O-sulfated heparan sulfate (3-OS HS) binder and antiviral agent. G2-Peptide blocks herpesvirus attachment, entry, cell-to-cell spread and syncytium formation, and reduces viral protein translocation. G2-Peptide exhibits antiviral activity against both HSV-1 and HSV-2. G2-Peptide inhibits neural activity and impairs synapse assembly. G2-Peptide can be used in the research of genital herpes, ocular herpes infection and keratitis[1][2][3].
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G2-Peptide | G2-Peptide is a 3-O-sulfated heparan sulfate (3-OS HS) binder and antiviral agent. G2-Peptide blocks herpesvirus attachment, entry, cell-to-cell spread and syncytium formation, and reduces viral protein translocation. G2-Peptide exhibits antiviral activity against both HSV-1 and HSV-2. G2-Peptide inhibits neural activity and impairs synapse assembly. G2-Peptide can be used in the research of genital herpes, ocular herpes infection and keratitis. | |||||||||||||||||||||
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- [1]. Ali MM, et al. A 3-O-sulfated heparan sulfate binding peptide preferentially targets herpes simplex virus 2-infected cells. Journal of virology. 2012 Jun;86(12):6434-43. [Content Brief]
- [2]. Tiwari V, et al. Anti-heparan sulfate peptides that block herpes simplex virus infection in vivo. The Journal of biological chemistry. 2011 Jul 15;286(28):25406-15. [Content Brief]
- [3]. Maïza A,, et al. 3-O-sulfated heparan sulfate interactors target synaptic adhesion molecules from neonatal mouse brain and inhibit neural activity and synaptogenesis in vitro. Sci Rep. 2020 Nov 5;10(1):19114. [Content Brief]
Keywords
