16 Results for "

1,4-dihydropyridine

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "1,4-dihydropyridine" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-135218A
CAS No.: 19350-66-4
Purity:  99.65%
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .
loading...
    loading...
Cat. No.: HY-118594
CAS No.: 632-93-9
Purity:  99.79%
Target:  

Ferrochelatase

Research Areas:  

Metabolic Disease

Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is an orally active porphyrin inducer and ferrochelatase inhibitor. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can induce small bile duct obstruction in mice, resulting in blocked bile excretion and causing cholestasis. Long-term use of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can cause damage to bile duct epithelial cells, inflammatory responses, and liver fibrosis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used to simulate the pathological features of cholestatic liver diseases such as sclerosing cholangitis (PSC) .
loading...
    loading...
Cat. No.: HY-W011231
CAS No.: 74936-72-4
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease

DHP-050 is a Felodipine (HY-B0309) analog. DHP-050 can be used to study the structure-activity relationship of 1,4-dihydropyridine (DHP) compounds .
loading...
    loading...
Cat. No.: HY-W267959
CAS No.: 1165-06-6
Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a pyridine derivative that can be synthesized by the reaction of benzaldehyde, ethyl acetoacetate and NH4HCO3 .
loading...
    loading...
Cat. No.: HY-U00034
CAS No.: 136941-85-0
Target:  

Drug Derivative

Research Areas:  

Cardiovascular Disease

PCA50941 is a 1,4-dihydropyridine derivative, used for treatment for cardiovascular disease.
loading...
    loading...
Cat. No.: HY-118594R
CAS No.: 632-93-9
Research Areas:  

Metabolic Disease

Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Standard) is the analytical standard of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate (HY-118594). This product is intended for research and analytical applications. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is an orally active porphyrin inducer and ferrochelatase inhibitor. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can induce small bile duct obstruction in mice, resulting in blocked bile excretion and causing cholestasis. Long-term use of Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can cause damage to bile duct epithelial cells, inflammatory responses, and liver fibrosis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used to simulate the pathological features of cholestatic liver diseases such as sclerosing cholangitis (PSC).
loading...
    loading...
Cat. No.: HY-106808
CAS No.: 118790-71-9
Synonyms: IOS-1.1212
Research Areas:  

Neurological Disease

Cerebrocrast (IOS-1.1212) is a 1,4-dihydropyridine (DHP) derivative. Cerebrocrast has a high affinity for the membrane lipid bilayer and it can easily penetrate the blood-brain barrier and incorporate into the plasma and organelle membranes, including those of mitochondria. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Cerebrocrast also exhibits neuroprotective and cognition enhancer properties .
loading...
    loading...
Cat. No.: HY-135218
CAS No.: 27296-05-5
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity .
loading...
    loading...
Cat. No.: HY-W025761
CAS No.: 199926-39-1
Target:  

MOFs

Research Areas:  

Others

4-Oxo-1,4-dihydropyridine-2,6-dicarboxylic acid hydrate is a metal-organic framework (MOF).
loading...
    loading...
Cat. No.: HY-19664R
CAS No.: 99522-79-9
Synonyms: OPC-13340 (Standard)
Pranidipine (Standard) is the analytical standard of Pranidipine. This product is intended for research and analytical applications. Pranidipine (OPC-13340) is a potent, long acting 1,4-dihydropyridine calcium channel blocker with antihypertensive activity .
loading...
    loading...
Cat. No.: HY-132707S
CAS No.: 1185133-69-0
2-[(2-Azidoethoxy-d4)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine is the deuterium labeled 2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine .
loading...
    loading...
Cat. No.: HY-W112151
CAS No.: 20443-03-2
Synonyms: 1,4-Dihydro-4-oxo-2,6-Pyridiedicarboxylic acid,dimethyl ester
Target:  

MOFs

Research Areas:  

Others

Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate (1,4-Dihydro-4-oxo-2,6-Pyridiedicarboxylic acid,dimethyl ester) is a metal-organic framework (MOF).
loading...
    loading...
Cat. No.: HY-W699942
CAS No.: 1189945-12-7
3-(2-Hydroxy-2-(methyl-d3)propyl-3,3,3-d3) 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is deuterated labeled 3-(2-Hydroxy-2-(methyl-)propyl-3,3,3-) 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.
loading...
    loading...
Cat. No.: HY-W700354
CAS No.: 105618-03-9
Target:  

Calcium Channel

(S)-(-)-Felodipine is a S-enantiomer of Felodipine. (S)-(-)-Felodipine is an antihypertensive agent. Felodipine is a 1,4-dihydropyridine derivative and a vasoselective calcium antagonist. Felodipine can prevent the activation of the vascular effector cells and interfere with the contractile process in vitro. Felodipine lowers mean arterial blood pressure by 20% in dog model. (S)-(-)-Felodipine shows high metabolic rate in rat and dog liver microsomes .
loading...
    loading...
Cat. No.: HY-33013R
CAS No.: 123853-39-4
Target:  

Reference Standards

4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid (Standard) is the analytical standard of 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid. This product is intended for research and analytical applications.
loading...
    loading...
Cat. No.: HY-33013S
Clevidipine impurity 24- 13C,d3 is 13C and deuterium labeled 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid .
loading...
    loading...
  • 1