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PCA50941 is a 1,4-dihydropyridine derivative, used for treatment for cardiovascular disease.

For research use only. We do not sell to patients.

PCA50941 Chemical Structure

PCA50941 Chemical Structure

CAS No. : 136941-85-0

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Description

PCA50941 is a 1,4-dihydropyridine derivative, used for treatment for cardiovascular disease.

In Vitro

PCA50941 (1 μM) shifts the I-V relationship of whole-cell Ca2+ currents by about 5-10 mV towards more hyperpolarizing potentials. PCA50941 increases further the K(+)-evoked peak to 655 nM. In the presence of 5 mM Ca2+, PCA50941 increases the [Ca2+] peaks to 427 nM. PCA50941 potentiates the release of catecholamines from perfused bovine adrenal glands evoked by 30 s pulses of 17.7 mM K+ in a manner dependent on the [Ca2+]o[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PCA50941 (10-120 μM) by intracoronary injection, causes smaller reductions of coronary blood flow (CBF) in goats. PCA50941 (10-300 μM/min) does not modify CBF nor the other hemodynamic variables recorded by i.v. infusions in 4 goats. Intravenous infusion of PCA50941 (100 microg/min) reverses the hemodynamic variables from the shock state to control values within 20 min in 5 of 6 animals[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

625.65

Formula

C30H31N3O10S

CAS No.
SMILES

O=C(C1=C(C)NC(C)=C(C(OCC2CCCCO2)=O)C1C3=CC=CC([N+]([O-])=O)=C3)OCCN(C(C4=C5C=CC=C4)=O)S5(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PCA50941 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PCA50941
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HY-U00034
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