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87

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By Targets:	17β-HSD (1) 5-HT Receptor (12) ADC Payload (2) Adenosine Deaminase (1) Adenosine Kinase (1) Adenosine Receptor (1) Adrenergic Receptor (9) Akt (3) AMPK (2) Amylases (1) Amyloid-β (4) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (1) Antibiotic (6) Apolipoprotein (1) Apoptosis (58) Arp2/3 Complex (2) Aryl Hydrocarbon Receptor (1) ASCT (1) Atg8/LC3 (1) ATP Synthase (4) Aurora Kinase (1) Autophagy (17) Bacterial (12) Bcl-2 Family (6) Bcr-Abl (2) Biochemical Assay Reagents (10) Btk (1) c-Fms (2) c-Met/HGFR (1) c-Myc (1) Cadherin (1) Calcium Channel (1) Cannabinoid Receptor (5) Carbonic Anhydrase (4) Carboxypeptidase (1) Casein Kinase (1) Caspase (8) Cathepsin (5) CCR (2) CD44 (1) CDK (12) Cholinesterase (ChE) (7) Complement System (1) COX (2) CXCR (1) Cytochrome P450 (6) Dengue Virus (1) Deubiquitinase (3) Dihydrofolate reductase (DHFR) (1) Dipeptidyl Peptidase (1) DNA Methyltransferase (2) DNA/RNA Synthesis (7) Dopamine Receptor (6) Drug Derivative (4) Drug Intermediate (3) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (2) EAAT (1) EBI2/GPR183 (1) EGFR (10) Elastase (1) ELOVL (1) Endogenous Metabolite (23) Endonuclease (1) Environmental Pollutants (7) Ephrin Receptor (2) Epigenetic Reader Domain (6) ERK (5) Estrogen Receptor/ERR (1) Factor Xa (1) FAK (4) FAP (1) Fat Mass and Obesity-associated Protein (FTO) (1) Fc Receptor (FcR) (2) Ferroptosis (4) FGFR (1) Filovirus (2) Flavivirus (1) FLT3 (2) Fluorescent Dye (3) Fungal (4) G Protein-coupled Receptor Kinase (GRK) (2) GABA Receptor (3) GCGR (1) Glutathione Peroxidase (1) Glycosidase (7) GlyT (3) GPR39 (1) GSK-3 (1) HDAC (6) Hedgehog (1) Heme Oxygenase (HO) (1) Herbicide (2) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (3) Histone Demethylase (3) Histone Methyltransferase (3) HIV (9) HSP (9) HSV (1) IAP (1) iGluR (2) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (2) Integrin (3) Interleukin Related (3) IPK Superfamily (1) IRAK (3) Isocitrate Dehydrogenase (IDH) (4) Isotope-Labeled Compounds (15) JAK (1) JNK (2) Keap1-Nrf2 (1) Large Tumor Suppressor (LATS) (1) Leukotriene Receptor (6) Lipoxygenase (1) LPL Receptor (1) LRRK2 (2) LXR (1) mAChR (3) Macrophage migration inhibitory factor (MIF) (1) MAP3K (2) MDM-2/p53 (2) Melatonin Receptor (1) Methionine Adenosyltransferase (MAT) (1) mGluR (1) MHC (2) Microtubule/Tubulin (14) Mitochondrial Metabolism (1) MMP (4) Molecular Glues (4) Monoamine Oxidase (7) mTOR (5) Na+/K+ ATPase (1) NAMPT (1) Nectin-4 (1) Neurokinin Receptor (2) NF-κB (5) NO Synthase (3) NOD-like Receptor (NLR) (4) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (2) OLIG2 (1) Opioid Receptor (1) Ornithine decarboxylase (ODC) (2) Oxysterol-binding Protein-related Protein (ORP) (1) P2X Receptor (5) p38 MAPK (3) p62 (1) Pantetheinase (1) Parasite (10) PARP (9) PCSK9 (1) PDGFR (1) PERK (1) Phosphatase (8) Phosphodiesterase (PDE) (5) Phospholipase (3) PI3K (6) Pim (1) PKC (1) Polo-like Kinase (PLK) (3) PPAR (1) Prion Protein (1) Prostaglandin Receptor (2) PROTACs (9) PSMA (2) Pyroptosis (2) Pyruvate Kinase (1) Raf (1) RAR/RXR (2) Ras (1) Reactive Oxygen Species (ROS) (23) Reference Standards (25) Reverse Transcriptase (3) RIP kinase (1) ROCK (1) ROS Kinase (1) SARS-CoV (6) Ser/Thr Protease (1) Serotonin Transporter (9) SHP2 (1) Sigma Receptor (1) Sirtuin (1) Small Interfering RNA (siRNA) (8) SNIPERs (1) Sodium Channel (1) Src (1) STAT (6) Steroid Sulfatase (1) Survivin (3) TAM Receptor (4) Tau Protein (1) TGF-β Receptor (1) Thrombin (1) Thymidylate Synthase (1) Tie (1) TMV (1) TNF Receptor (4) TNK1 (2) Topoisomerase (4) Trk Receptor (1) TRP Channel (3) Tyrosinase (3) ULK (1) VD/VDR (1) VEGFR (9) Virus Protease (2) Wee1 (1) Wnt (2) YAP (2) β-catenin (3)
By Research Areas:	Cancer (221) Cardiovascular Disease (18) Endocrinology (15) Infection (47) Inflammation/Immunology (66) Metabolic Disease (23) Neurological Disease (80)
Click Chemistry:	Azide (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (5) Polymers (4) siRNAs (8)

419

Inhibitors & Agonists

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15836

BAY 87-2243 25+ Cited Publications	HIF/HIF Prolyl-Hydroxylase Ferroptosis	Cancer
BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.

HY-B1490

Imipramine hydrochloride 5+ Cited Publications	Serotonin Transporter Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects .

HY-B1490A

Imipramine 5+ Cited Publications	Serotonin Transporter Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-Y0850E

Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) 3 Publications Verification PVA (Mw 30000-70000, 87-90% hydrolyzed); Poly(Ethenol) (Mw 30000-70000, 87-90% hydrolyzed)	Environmental Pollutants Biochemical Assay Reagents	Cardiovascular Disease Cancer
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 30000-70000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-90% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipients .

HY-N2146

Combretastatin A4 4 Publications Verification CRC 87-09	Microtubule/Tubulin	Cancer
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM.

HY-D0505

Eosin Y 3 Publications Verification Acid Red 87 free base	Fluorescent Dye	Others
Eosin Y (Acid Red 87 free base) is a soluble acid red dye molecule. Eosin Y has a wide application in organic synthesis as a photoredox catalyst .

HY-Y0850J

Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) 3 Publications Verification PVA (Mw 13000-23000, 87-89% hydrolyzed); Poly(Ethenol) (Mw 13000-23000, 87-89% hydrolyzed)	Environmental Pollutants Biochemical Assay Reagents	Cancer
Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 130000-23000 and hydrolytic properties. Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate and polyvinyl alcohol is obtained. A degree of hydrolysis of 87-89% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient. Polyvinyl alcohol can be used in tissue engineering by electrospinning. Polyvinyl alcohol can achieve high cellular density, infiltration, and uniform distribution, facilitating functional connections between cells. Polyvinyl alcohol can improve cell vitality through in vitro cultivation. Polyvinyl alcohol demonstrates promising inhibition of ostersarcoma cancer cells with Doxorubicin (HY-15142A) .

HY-Y0850M

Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) 3 Publications Verification PVA (Mw 85000-124000, 87-89% hydrolyzed); Poly(Ethenol) (Mw 85000-124000, 87-89% hydrolyzed)	Environmental Pollutants Biochemical Assay Reagents	Others
Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 85000-124000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-89% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient .

HY-Y0850P

Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed) 3 Publications Verification PVA (Mw 146000-186000, 87-89% hydrolyzed); Poly(Ethenol) (Mw 146000-186000, 87-89% hydrolyzed)	Environmental Pollutants Biochemical Assay Reagents	Cancer
Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 146000-186000 and hydrolytic properties. Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient. Polyvinyl alcohol can be used in tissue engineering by electrospinning. Polyvinyl alcohol can achieve high cellular density, infiltration, and uniform distribution, facilitating functional connections between cells. Polyvinyl alcohol can improve cell vitality through in vitro cultivation. Polyvinyl alcohol demonstrates promising inhibition of ostersarcoma cancer cells with Doxorubicin (HY-15142A) .

HY-D0505A

Eosin Y disodium 3 Publications Verification Acid Red 87	Fluorescent Dye	Others
Eosin Y disodium (Acid Red 87) is a soluble acid red dye molecule. Eosin Y disodium has a wide application in organic synthesis as a photoredox catalyst .

HY-100735

C 87 2 Publications Verification	TNF Receptor	Inflammation/Immunology
C 87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC₅₀ of 8.73 μM.

HY-Y0850O

Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed) 3 Publications Verification PVA (Mw 31000-50000, 87-89% hydrolyzed); Poly(Ethenol) (Mw 31000-50000, 87-89% hydrolyzed)	Environmental Pollutants Biochemical Assay Reagents	Cancer
Polyvinyl alcohol (PVA; Poly (Ethenol)) (Mw 31000-50000, 87-89% hydrolyzed) is a polymer with emulsifying and stabilizing properties, with a degree of hydrolysis of 87-89%. Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed) mainly acts as a stabilizer in the preparation of nanomedicines; it not only maintains the structural integrity of PEGylated PLGA nanoparticles during double emulsion synthesis, but also facilitates the preparation of chitosan/matrine-PLGA nanoparticle aqueous solutions and lipid-polymer nanoparticles. Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed) can be widely used in research related to fields such as breast cancer .

HY-Y0850U9

PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization) Polyvinyl alcohol (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization); Poly(Ethenol) (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization) is a polyvinyl alcohol with a molecular weight of 67000 and hydrolytic properties. Degree of hydrolysis refers to the conversion rate of acetate groups in the original polyvinyl acetate to hydroxyl groups; PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization) is obtained by hydrolyzing and removing acetate groups after the polymerization of vinyl acetate. Polyvinyl alcohol with different degrees of hydrolysis can be used to form self-crosslinked cryogels and is applied as a biological adjuvant .

HY-107496

Imidocarb dipropionate 1 Publications Verification	Parasite Antibiotic	Infection
Imidocarb dipropionate is a potent antiprotozoal agent. Imidocarb dipropionate is active against the parasite B. bovis with an IC₅₀ of 87 μg/mL .

HY-15811

XMD8-87 ACK1-B19	Tyrosinase	Cancer
XMD8-87 is a potent TNK2 inhibitor with IC₅₀ values of 38 and 113 nM for the D163E and R806Q mutations, respectively.

HY-D1005B

Poloxamer 237 (F87) 1 Publications Verification PEG-PPG-PEG, 7700 (Average Mn)	Environmental Pollutants	Others
Poloxamer 237 (F87) (PEG-PPG-PEG, 7700 (Average Mn)) is an alcohol substance that acts as an oil-in-water emulsifier and solubilizer. Poloxamer 237 (F87) is used in the research of formulations such as contact lens care solutions and eye drops .

HY-100555

CH5138303	HSP	Infection Cancer
CH5138303 is a potent and orally active Hsp90 inhibitor. CH5138303 shows high binding affinity for N-terminal Hsp90α, with K_d of 0.52 nM. CH5138303 shows potent anti-proliferative activity against human cancer cell lines (HCT116 and NCI-N87), with IC₅₀ values of 0.098 and 0.066 μM, respectively. CH5138303 shows high oral bioavailability in mice (F=44.0%). CH5138303 shows potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model .

HY-116273

ML299	Phospholipase	Cancer
ML299 is a selective allosteric modulator and a dual inhibitor of phospholipases D1 and D2 (IC₅₀ values are 6 and 12 nM, respectively). ML299 decreases invasive migration in U87-MG glioblastoma cells .

HY-106850

3′-Azido-2′,3′-dideoxyuridine AzdU; AzddU; CS-87	HIV	Infection
3′-Azido-2′,3′-dideoxyuridine (AzdU) is a nucleoside analog of Zidovudine (HY-17413). 3′-Azido-2′,3′-dideoxyuridine is a potent inhibitor of human immunodeficiency virus (HIV) replication in human peripheral blood mononuclear cells (PBMC) with limited toxicity for human bone marrow cells (BMC) . 3′-Azido-2′,3′-dideoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-135611

Imidocarb 1 Publications Verification	Parasite Antibiotic	Infection
Imidocarb is a potent antiprotozoal agent. Imidocarb is active against the parasite B. bovis with an IC₅₀ of 87 μg/mL .

HY-106892

BW 348U87 348U87	DNA/RNA Synthesis	Infection
BW 348U87 is an inhibitor for ribonucleotide reductase, which exhibits synergistic effect with Acyclovir (HY-17422), potentiate the antiviral activity of Acyclovir against herpes simplex virus (HSV) in athymic nude mouse model .

HY-155439

FAK-IN-14	FAK	Cancer
FAK-IN-14 (compound 8d) is a focal adhesion kinase(FAK) inhibitor with an IC₅₀ value of 0.2438 nM. FAK-IN-14 induces U87-MG cell early apoptosis and arrest the cell at the G2/M phase .

HY-168708

AH2-14c	Histone Demethylase Apoptosis	Cancer
AH2-14c is an inhibitor for DNA demethylase ALKBH2. AH2-14c inhibits the cell viability (IC₅₀ is 4.56 µM) and migration of GBM U87. AH2-14c regulates the expression of apoptosis-related genes, and induces apoptosis in GBM U87 cell .

HY-129619

SNIPER(ER)-87	SNIPERs Estrogen Receptor/ERR	Cancer
SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC₅₀=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation .

HY-P1750

Shepherdin (79-87)	HSP Survivin	Cancer
Shepherdin (79-87) is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity .

HY-134557

GS87	GSK-3	Cancer
GS87 is a highly specific and potent GSK3 inhibitor with IC₅₀s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research .

HY-P1750A

Shepherdin (79-87) TFA	HSP Survivin	Cancer
Shepherdin (79-87) TFA is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity .

HY-Y0850U2

PVA (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization) Polyvinyl alcohol (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization); Poly(Ethenol) (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization) (Polyvinyl alcohol (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization); Poly(Ethenol) (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization)) is a biodegradable of polymer. PVA (Mw 130000, 87-89% hydrolyzed, ~2700 polymerization) can be used to blend with various biopolymers and hydrophilic synthetic polymers to improve mechanical properties of films .

HY-Y0850U

PVA (Mw 31000, 87-89% hydrolyzed, ~630 polymerization) Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ~630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ~630 polymerization)	Biochemical Assay Reagents	Others
PVA (Mw 31000, 87-89% hydrolyzed, ~630 polymerization) (Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ~630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ~630 polymerization)) is a biocompatible, biodegradable, nontoxic and hydrophilic synthetic polymer. PVA (Mw 31000, 87-89% hydrolyzed, ~630 polymerization) can be used to produce bone tissue engineering scaffold ^[1]

HY-118785

MSP-3	TRP Channel	Neurological Disease
MSP-3 is a potent TRPV1 agonist, with an EC₅₀ of 0.87 μM. MSP-3 exhibits neuroprotective and antinociceptive effects .

HY-173053

HDAC-IN-87	HDAC Fungal	Infection
HDAC-IN-87 (Compound XII6) is a nonselective HDAC inhibitor, with pIC50 of 6.9 (HDAC4) and 5.8 (HDAC6) respectively. HDAC-IN-87 has fungicidal activity against P. sorghi and P. pachyrhizi. HDAC-IN-87 shows an acute oral LD₅₀ of greater than 500 mg/kg in male and female rats .

HY-156741A

EGFR-IN-87 hydrochloride	EGFR	Cancer
EGFR-IN-87 (Compound Example 2) hydrochloride is a EGFR tyrosine kinase inhibitor. EGFR-IN-87 hydrochloride has IC₅₀ value of 3.1 nM, 1.3 nM and 7.1 nM for EGFR_d746-750, EGFR_L858R/T790 and EGFR_WT in A431 cells, respectively. EGFR-IN-87 hydrochloride can be used for cancer diseases research .

HY-116165

ML-298	Phospholipase	Cancer
ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC₅₀ of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells .

HY-13768S1

Topotecan-d6	Isotope-Labeled Compounds Topoisomerase Autophagy	Cancer
Topotecan-d₆ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC₅₀ values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87 .

HY-W1117786

Nampt-IN-10	ADC Payload NAMPT	Cancer
Nampt-IN-10 (Compound 4) is an efficient inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). Nampt-IN-10 exhibits nanomolar-level inhibitory activity against cell lines such as MDA-MB453, NCI-N87, and NCI-H526. Nampt-IN-10 can be used as an ADC payload, and the ADC constructed with it as the core demonstrates significant anti-tumor activity .

HY-156741

EGFR-IN-87	EGFR	Cancer
EGFR-IN-87 (Compound Example 2) is a EGFR tyrosine kinase inhibitor. EGFR-IN-87 has IC₅₀ value of 3.1 nM, 1.3 nM and 7.1 nM for EGFR_d746-750, EGFR_L858R/T790 and EGFR_WT in A431 cells, respectively. EGFR-IN-87 can be used for cancer diseases research .

HY-19130

BW-534U87	Adenosine Receptor	Neurological Disease
BW-534U87 is an orally active adenosine A1 receptor agonist and competitive adenosine deaminase (ADA) inhibitor (K_i=7 μM). BW-534U87 elevates brain adenosine levels and suppresses epileptiform activity. BW-534U87 demonstrate anticonvulsant efficacy in animal seizure models. BW-534U87 is promising for research of epilepsy and adenosine-related neuropsychiatric disorders .

HY-105102

Netivudine 882C87	Nucleoside Antimetabolite/Analog HSV	Infection
Netivudine is a nucleoside analogue with potent anti-varicella zoster virus activity. Netivudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-156349

Sec61-IN-4	Apoptosis	Others
Sec61-IN-4 (Compound 16b) is a Sec61 inhibitor (IC₅₀: 0.04 nM in U87-MG cells) .

HY-N1187

Syzalterin 1 Publications Verification	NO Synthase	Neurological Disease Inflammation/Immunology
Syzalterin is an inhibitor of NO production with an IC₅₀ of 1.87 μg/mL.

HY-N2146R

Combretastatin A4 (Standard) CRC 87-09 (Standard)	Reference Standards Microtubule/Tubulin	Cancer
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

HY-157085

BX-2819	HSP	Cancer
BX-2819 is a Hsp90 inhibitor with an IC₅₀ value of 41 nM. BX-2819 inhibits the proliferation of cancer cells. BX-2819 can significantly inhibit the growth of NCI-N87 and HT-29 tumors in nude mice .

HY-176538

Antiproliferative agent-72	HSP	Cancer
Antiproliferative agent-72 (Compound 10) is a Hsp90 inhibitor with a K_d of 11 nM. Antiproliferative agent-72 has antiproliferative activity with IC₅₀s of 1.5  μM and 1.1 μM for HCT116 and NCI-N87 cells, respectively. Antiproliferative agent-72 can be used for cancers research .

HY-175213

Mutant IDH1-IN-7	Isocitrate Dehydrogenase (IDH)	Cancer
Mutant IDH1-IN-7 is a highly selective Isocitrate Dehydrogenase 1 (IDH1) R132H (IC₅₀ = 0.26 μM, K_d = 2.1 μM)/R132C (IC₅₀ = 1.1 μM) inhibitor. Mutant IDH1-IN-7 has no inhibitory effect on wild-type IDH1, IDH2-wt, and IDH2 R140Q. Mutant IDH1-IN-7 inhibits 2-Hydroxyglutarate (2-HG) production in U87-MG R132H cells (EC₅₀ = 0.55 μM). Mutant IDH1-IN-7 exhibits moderate antiproliferative effects on U87-MG R132H and HT-1080 cells .

HY-W040303

Flumetsulam DE-498; XRD-498	Environmental Pollutants Herbicide	Others
Flumetsulam is pre- and postemergence herbicide, which is susceptible to dissipate in corn ecosystem with half-live less than 8.7 days .

HY-157778

MK-7845	SARS-CoV	Infection
MK-7845 is a reversible covalent SARS-CoV-2 3CL protease inhibitor with an IC₅₀ of 8.7 nM .

HY-144190

MIF-IN-1	Macrophage migration inhibitory factor (MIF)	Neurological Disease
MIF-IN-1 (compound 14) is a potent macrophage migration inhibitory factor (MIF) inhibitor (pIC₅₀=6.87) .

HY-15990

CH5164840	HSP	Cancer
CH5164840 (16) shows high binding affinity for N-terminal Hsp90a (K_d = 0.52 nM) and strong anti-proliferative activity against human cancer cell lines (HCT116 IC₅₀ = 0.15 μM, NCI-N87 IC₅₀ = 0.066 μM). CH5164840 (16) is orally active (t_1/2 = 2.64 h) with potent antitumor efficacy .

HY-148592

Antitumor agent-87	Cytochrome P450	Cancer
Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a K_i value of 0.23 µM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity .

HY-151570

Anticancer agent 87	Others	Cancer
Anticancer agent 87 is a potent anticancer agent. Anticancer agent 87 can be used in the research of breast adenocarcinoma and liver cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0471

Phenylephrine hydrochloride Maximum Cited Publications 34 Publications Verification (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Cardiovascular Disease Alkaloids Monophenols Classification of Application Fields Other Alkaloids Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
(R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-12033

2-Methoxyestradiol 30+ Cited Publications 2-ME2; NSC-659853	Monophenols Classification of Application Fields Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer Source Classification	Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-N2146

Combretastatin A4 4 Publications Verification CRC 87-09	Structural Classification Monophenols other families Stilbenes Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with K_d of 0.4 μM.

HY-B0754A

Hematoporphyrin dihydrochloride 10+ Cited Publications Hematoporphyrin IX dihydrochloride	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-100542

D-α-Hydroxyglutaric acid disodium 4 Publications Verification Disodium (R)-2-hydroxyglutarate	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-N1454

Apigenin-7-glucuronide 4 Publications Verification Apigenin 7-O-glucuronide	Structural Classification Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	MMP
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-113038

D-α-Hydroxyglutaric acid 4 Publications Verification (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid	Classification of Application Fields Neurological Disease Anti-aging Endocrine diseases Endogenous metabolite Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer Source Classification	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-N0464

D-(-)-Quinic acid 3 Publications Verification	Infection Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Glycosidase Monoamine Oxidase
D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-W008364

Olivetol	Microorganisms other families Phenols Polyphenols Plants Source Classification	Cytochrome P450 Cannabinoid Receptor
Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2 . Olivetol also inhibits CYP2C19 and CYP2D6 activity, with IC₅₀s of 15.3 μM, 7.21 μM and K_is of 2.71 μM, 2.87 μM, respectively .

HY-124481

Oleocanthal	Monophenols Canarium album (Lour.) Rauesch. Phenols Plants Burseraceae Source Classification	COX Reactive Oxygen Species (ROS) NO Synthase Keap1-Nrf2 Heme Oxygenase (HO) Amyloid-β Parasite
Oleocanthal is an orally active phenolic seciridoid compound. Oleocanthal can be extracted from olive oil. Oleocanthal inhibits COX-1 and COX-2, reduces ROS and NO, and upregulates Nrf-2 and HO-1. Oleocanthal reduces Aβ deposition. Oleocanthal exhibits anti-Leishmania activity against promastigotes and amastigotes of L. major, with IC₅₀ values of 18.7 and 87 μg/mL, respectively. Oleocanthal exhibits anticancer activity against colon, breast, liver, and melanoma cancers. Oleocanthal also exhibits anti-inflammatory and neuroprotective properties. Oleocanthal can be used in Alzheimer's disease research .

HY-N1374

Magnolin 2 Publications Verification	Classification of Application Fields Magnoliaceae Lignans Magnolia Liliflora Desr. Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	ERK
Magnolin, a major component of Magnolia liliiflora, inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC₅₀s of 87 nM and 16.5 nM, respectively.

HY-B0754

Hematoporphyrin Hematoporphyrin IX	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-N6037

Gardenin B	Monophenols Flavonoids Classification of Application Fields Flavones Rubiaceae Phenols Plants Gardenia jasminoides Ellis Disease Research Fields Source Classification Cancer	Apoptosis Deubiquitinase Ornithine decarboxylase (ODC) Cathepsin Reactive Oxygen Species (ROS) Caspase
Gardenin B is a methoxyflavone compound and an inhibitor of USP7, ODC (IC₅₀: 6.24 μg/mL), and Cathepsin D (IC₅₀: 5.61 μg/mL). Gardenin B exhibits antioxidant and antitumor activities. Gardenin B shows IC₅₀ values of 8.87 and 10.59 μg/mL for DPPH and NO scavenging, respectively, and also possesses ferric ion reducing ability. Additionally, Gardenin B can inhibit tumor cell proliferation, induce cell cycle arrest and apoptosis. Gardenin B can be used in cancer research .

HY-117469

Triptohypol C	Triterpenes Ketones, Aldehydes, Acids Terpenoids Celastraceae Tripterygium wilfordii Hook. f. Plants	Nuclear Hormone Receptor 4A/NR4A p62
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an K_d value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1 .

HY-113314

AFMK	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pK_a of AFMK at physiological pH is 8.7. Antioxidant capacity . AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway .

HY-N10450

Kumujian A 1-Ethoxycarbonyl-β-carboline	Alkaloids Simaroubaceae Plants Picrasma quassioides(D．Don)Benn． Indole Alkaloids Source Classification	Reactive Oxygen Species (ROS)
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC₅₀ = 4.87 μg/mL) and elastase release (IC₅₀ = 6.29 μg/mL) .

HY-N3001

Isolinderalactone 1 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Plants Lauraceae Lindera aggregata (Sims) Kosterm. Disease Research Fields Source Classification Cancer	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .

HY-B0471R

Phenylephrine hydrochloride (Standard) (R)-(-)-Phenylephrine hydrochloride (Standard); L-Phenylephrine hydrochloride (Standard)	Structural Classification Alkaloids Monophenols Other Alkaloids Phenols Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Endogenous Metabolite
Phenylephrine (hydrochloride) (Standard) is the analytical standard of Phenylephrine (hydrochloride). This product is intended for research and analytical applications. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-N16513

Muurol-4-ene-3,8-dione	Structural Classification Pongamia pinnata (L.) Pierre Terpenoids Sesquiterpenes Plants Compositae Source Classification	Others
Muurol-4-ene-3,8-dione (Compound 2), a sesquiterpene, is one of the main hepatotoxic components in Eupatorium adenophorum. Muurol-4-ene-3,8-dione has an inhibitory effect on the growth of both the normal human hepatocyte cell L02 and the human hepatocellular carcinoma cell HepG2 with IC₅₀ values of 87.52 and 104.48 μM .

HY-N1454R

Apigenin-7-glucuronide (Standard) Apigenin 7-O-glucuronide (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Reference Standards MMP
Apigenin-7-glucuronide (Standard) is the analytical standard of Apigenin-7-glucuronide. This product is intended for research and analytical applications. Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-N1187

Syzalterin 1 Publications Verification	Flavonoids Lawsonia inermis L. Lythraceae Flavones Phenols Polyphenols Plants Source Classification	NO Synthase
Syzalterin is an inhibitor of NO production with an IC₅₀ of 1.87 μg/mL.

HY-N2146R

Combretastatin A4 (Standard) CRC 87-09 (Standard)	Structural Classification Monophenols other families Stilbenes Phenols Plants Source Classification	Reference Standards Microtubule/Tubulin
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

HY-W019829

Polyphyllin C	Infection other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	Tyrosinase Parasite
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the tyrosinase and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities .

HY-N3634

Corylifol C	Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Source Classification	EGFR TAM Receptor Tie
Corylifol C is a potent protein kinase inhibitor with IC₅₀ valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .

HY-N6037R

Gardenin B (Standard)	Structural Classification Monophenols Flavonoids Flavones Rubiaceae Phenols Plants Gardenia jasminoides Ellis Source Classification	Reference Standards Apoptosis Ornithine decarboxylase (ODC) Reactive Oxygen Species (ROS) Cathepsin Deubiquitinase Caspase
Gardenin B (Standard) is the analytical standard of Gardenin B (HY-N6037). This product is intended for research and analytical applications. Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B is a methoxyflavone compound and an inhibitor of USP7, ODC (IC₅₀: 6.24 μg/mL), and Cathepsin D (IC₅₀: 5.61 μg/mL). Gardenin B exhibits antioxidant and antitumor activities. Gardenin B shows IC₅₀ values of 8.87 and 10.59 μg/mL for DPPH and NO scavenging, respectively, and also possesses ferric ion reducing ability. Additionally, Gardenin B can inhibit tumor cell proliferation, induce cell cycle arrest and apoptosis. Gardenin B can be used in cancer research .

HY-N11982

Emeguisin A	Monophenols Microorganisms Phenols Source Classification	Bacterial
Emeguisin A is a depsidone with an antibacterial activity. Emeguisin A inhibits the human colon carcinoma (HCT-116) cell viability with rate of 87.06% .

HY-N12834

Ecdysoside B	Apocynaceae Structural Classification Plants Urceola rosea (Hook. & Arn.) D. J. Middleton Steroids Source Classification	Others
Ecdysoside B (compound 6b) is a pregnanoside compound isolated from the plant Ecdysanthera rosea. Ecdysoside B and its derivatives and isomers shows anticancer, immunosuppressive and anti-inflammatory activities. Ecdysoside B shows cytotoxicity to a variety of human tumor cell lines, including PANC-1 (human pancreatic cancer cells), A375 (human melanoma cells) and U87 (brain glioma U87 cells). Ecdysoside B can be used for research in the areas of cancer, immunomodulation and anti-inflammato .

HY-N10130

Isouvaretin	Infection Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Dihydrochalcones Disease Research Fields Source Classification	Bacterial
A mixture of uvaretin (HY-N10129) and isouvaretin exhibits significant antibacterial activity against B. subtilis (EC₅₀ 8.7 μM) and S. epidermidis (IC₅₀ 7.9 μM).

HY-N11840

Mortatarin F	Flavanonols Flavonoids Phenols Polyphenols Morus alba L. Plants Moraceae Source Classification	Glycosidase
Mortatarin F (Compound 1) is an inhibitor of α‑glucosidase with an IC₅₀ of 8.7 μΜ. Mortatarin F is an renylated flavonoid that can be isolated from mulberry leaves and can be used for hypoglycemic research .

HY-N10378

Rubrofusarin 6-O-β-D-glucopyranoside	Monophenols Classification of Application Fields Neurological Disease Phenols Metabolic Disease Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Disease Research Fields Source Classification	Phosphatase
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC₅₀ of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression .

HY-N1374R

Magnolin (Standard)	Structural Classification Magnoliaceae Lignans Magnolia Liliflora Desr. Phenylpropanoids Plants Source Classification	Reference Standards ERK
Magnolin (Standard) is the analytical standard of Magnolin. This product is intended for research and analytical applications. Magnolin, a major component of Magnolia liliiflora, inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC₅₀s of 87 nM and 16.5 nM, respectively.

HY-N0464R

D-(-)-Quinic acid (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Glycosidase Monoamine Oxidase
D-(-)-Quinic acid (Standard) is the analytical standard of D-(-)-Quinic acid. This product is intended for research and analytical applications. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-N13041

Acacetin 7-O-(6-O-malonylglucoside)	Flavonoids Flavones Ligularia veitchiana (Hemsl.) Greenm. Labiatae Plants Source Classification	Monoamine Oxidase
Acacetin 7-O-(6-O-malonylglucoside) is a monoamine oxidase inhibitor with strong inhibitory effects on monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC₅₀ values of 2.34 and 1.87 μM, respectively. Acacetin 7-O-(6-O-malonylglucoside) is a reversible MAO inhibitor that can be used in the research of neurodegenerative diseases and affective disorders .

HY-N12887

Mycothiazole	Natural Products Marine natural products Sponge Source Classification	Mitochondrial Metabolism
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .

HY-N12641

Ardisianone	Quinones Benzene Quinones Plants Primulaceae Source Classification	Apoptosis Pyroptosis
Ardisianone is a component with an alkyl benzoquinone structure that can be isolated from Ardisia virens Kurz and Ardisia compressa tea extract. Ardisianone exhibits potent antileukemic activity, particularly against HL-60 cells, with IC₅₀ values of 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. Ardisianone can be used for the study of acute myeloid leukemia (AML) .

HY-W008364R

Olivetol (Standard)	Structural Classification Microorganisms other families Phenols Polyphenols Plants Source Classification	Reference Standards Cytochrome P450 Cannabinoid Receptor
Olivetol (Standard) is the analytical standard of Olivetol. This product is intended for research and analytical applications. Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2 . Olivetol also inhibits CYP2C19 and CYP2D6 activity, with IC50s of 15.3 μM, 7.21 μM and Kis of 2.71 μM, 2.87 μM, respectively .

HY-N15309

Torvoside C Torvoside K	Structural Classification Solanum torvum Swartz Solanaceae Plants Steroids Source Classification	Fungal
Torvoside C (Torvoside K) is a compound found in Solanum torvum with antifungal activity. The ZOIs and MIC values of Torvoside C against the tested fungi (Alternaria brassicicola, Alternaria geophila, Aspergillus flavus, etc.) range from 33.4% to 87.4% and 31.25 to 250 μg/mL, respectively. Additionally, it exhibits a dose-dependent inhibitory effect on the production of mycotoxins aflatoxin B1 and fumonisin B1, which are produced by A. flavus and F. verticillioides, respectively. Torvoside C can be used for research in the field of antifungal infection .

HY-N12589

8-epi-Helenalin	Terpenoids Sesquiterpenes Plants Compositae Piptanthus nepalensis (Hook.) D. Don Source Classification	Others
8-epi-Helenalin is a semitterpene lactone with anti-tumor activity that can be isolated from Inula britannicaL. var. chinensis (Rupr.) Reg. and the ED₅₀ values of 8-epi-Helenalin for HL-60, A549, MCF7, HCT-15, SK-OV-3 and Malme-3M are 12.2 μM, 53.8 μM, 9.1 μM, 8.7 μM, 18.7 μM and 8.3 μM, respectively. 8-epi-Helenalin can be used for anti-tumor studies .

HY-12033R

2-Methoxyestradiol (Standard) 2-ME2 (Standard); NSC-659853 (Standard)	Structural Classification Monophenols Disease markers Phenols Endocrine diseases Endogenous metabolite Steroids Cancer Source Classification	Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite Reference Standards
2-Methoxyestradiol (Standard) is the analytical standard of 2-Methoxyestradiol. This product is intended for research and analytical applications. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-100542R

D-α-Hydroxyglutaric acid disodium (Standard) Disodium (R)-2-hydroxyglutarate (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-α-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-N12135

15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide	Senegalia pennata (L.) Maslin Terpenoids Labiatae Diterpenoids Plants Source Classification	Others
15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (compound 2) is an enantio-kaurene diterpenoid (ent -kaurene diterpenoid), which can be isolated from Rubescens rubescens. 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide has cellular activity against EC-1, U87, A549, MCF-7 and HeLa cell lines Toxicity, IC₅₀s are 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, 462.13 μM, and 180.09 μM respectively .

HY-N8626

8-(7-Hydroxy-3,7-dimethyl-2,5-octadienyloxy)psoralen	Phebalium tuberculosum (F.Muell.) Benth. Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Others
8-(7-Hydroxy-3,7-dimethyl-2,5-octadienyloxy)psoralen is a Coumarins product that can be isolated from the herbs of Phebalium tuberculosum ssp. megaphyllum .

HY-N13896

Aureoquinone	Quinones Microorganisms Naphthalene Quinones Source Classification	Ser/Thr Protease
Aureoquinone is a broad-spectrum protease inhibitor. Aureoquinone inhibits trypsin, papain, thermophilic protease, collagenase and pound-protease, with IC₅₀ values of 11.4 μg/mL, 14.5 μg/mL, 17.8 μg/mL, 7.1 μg/mL, and 8.7 μg/mL, respectively .

HY-N19401

Vescalagin	Structural Classification Phenols Polyphenols Myrciaria dubia (Kunth) McVaugh Myrtaceae Plants Source Classification	Cholinesterase (ChE) Carbonic Anhydrase Glycosidase JNK p38 MAPK
Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu (Myrciaria dubia) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes, with a K_i value of 5.87 nM against AChE, 3.89 nM against BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against α-glucosidase. Vescalagin inhibits hCA I, hCA II and α-glucosidase in a non-competitive manner. Vescalagin downregulates JNK/p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties .

HY-N13817

(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol	Structural Classification Pinaceae Terpenoids Pityrogramma triangularis Diterpenoids Plants Source Classification	NF-κB
(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a diterpene found in Abies georgei. (8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a nuclear factor kappa B (NF-κB) inhibitor that inhibits TNFα-triggered NF-κB activity (IC₅₀ = 8.7 μg/mL). (8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol exhibits anti-inflammatory activity and can inhibit NO production. (8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol shows significant cytotoxicity against tumor cells .

Cat. No.	Product Name	Chemical Structure

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-W654003

D-α-Hydroxyglutaric acid-d5 disodium

D-α-Hydroxyglutaric acid-d₅ disodium (Disodium (R)-2-hydroxyglutarate-d₅) is the deuterium labeled D-α-Hydroxyglutaric acid disodium (HY-100542). D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-122524S

7-Methylguanosine-d3
7-Methylguanosine-d₃ is the deuterium labeled 7-Methylguanosine . 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC₅₀ value of 87.8 ± 7.5 μM .

HY-16106S

Talazoparib-13C,d4
Talazoparib- ¹³C,d4 is ¹³C and deuterated labeled Talazoparib (HY-16106). Talazoparib is an orally active PARP 1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM for inhibiting PARP1 and PARP2 enzymatic activities, respectively. Has anti-tumor activity.

HY-13768S1

Topotecan-d6
Topotecan-d₆ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC₅₀ values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87 .

HY-16106S1

Talazoparib-d4
Talazoparib-d₄ (BMN-673-d₄) is deuterium labeled Talazoparib. Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with K_is of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity .

HY-B1490AS

Imipramine-d6

Imipramine-d₆ is the deuterium labeled Imipramine hydrochloride. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B1490S1

Imipramine-d3 hydrochloride

Imipramine-d₃ (hydrochloride) is deuterium labeled Imipramine (hydrochloride). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B0471S

Phenylephrine-d3 hydrochloride
Phenylephrine-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-N0464S

Quinic acid-13C3
Quinic acid- ¹³C₃ is the ¹³C-labeled D-(-)-Quinic acid. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-B0471S1

Phenylephrine-2,4,6-d3 hydrochloride
Phenylephrine-2,4,6-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-13768S

Topotecan-d5
Topotecan-d₅ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC₅₀ values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87 .

HY-B1490S

Imipramine-d4 hydrochloride

Imipramine-d₄ (hydrochloride) is the deuterium labeled Imipramine hydrochloride. Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects .

HY-B1490AS1

Imipramine-d4

Imipramine-d₄ is deuterium labeled Imipramine. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B1490AS3

Imipramine-d4-1

Imipramine-d4-1 is the deuterium labeled Imipramine (HY-W010179). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B0471S3

Phenylephrine-d6 hydrochloride
Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S2

(S)-Phenylephrine-d6 hydrochloride
(S)-Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-W779800

D-α-Hydroxyglutaric acid-13C5 disodium

D-α-Hydroxyglutaric acid- ¹³C₅ disodium is the ¹³C-labeled D-α-Hydroxyglutaric acid (HY-113038). D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling .

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