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Pathways Recommended:	MAPK/ERK Pathway

Results for "

AMPK/ACC pathway

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (4) AMPK (7) Acyltransferase (1) Akt (2) Apoptosis (5) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Carnitine Palmitoyltransferase (CPT) (1) Caspase (2) Drug Derivative (2) ERK (1) Fatty Acid Synthase (FASN) (1) GSK-3 (1) HSV (2) Mitochondrial Metabolism (1) NF-κB (2) NOD-like Receptor (NLR) (2) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (1) PI3K (2) PKA (1) Platelet-activating Factor Receptor (PAFR) (1) PPAR (3) Reactive Oxygen Species (ROS) (3) Reference Standards (1) SOD (1) TRP Channel (1) VEGFR (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Endocrinology (1) Infection (3) Inflammation/Immunology (3) Metabolic Disease (6) Neurological Disease (4)

By Targets:

Acetyl-CoA Carboxylase (4)

AMPK (7)

Acyltransferase (1)

Akt (2)

Apoptosis (5)

Autophagy (1)

Bacterial (1)

Bcl-2 Family (1)

Carnitine Palmitoyltransferase (CPT) (1)

Caspase (2)

Drug Derivative (2)

ERK (1)

Fatty Acid Synthase (FASN) (1)

GSK-3 (1)

HSV (2)

Mitochondrial Metabolism (1)

NF-κB (2)

NOD-like Receptor (NLR) (2)

Nuclear Factor of activated T Cells (NFAT) (1)

p38 MAPK (1)

PI3K (2)

PKA (1)

Platelet-activating Factor Receptor (PAFR) (1)

PPAR (3)

Reactive Oxygen Species (ROS) (3)

Reference Standards (1)

SOD (1)

TRP Channel (1)

VEGFR (2)

By Research Areas:

Cancer (5)

Cardiovascular Disease (1)

Endocrinology (1)

Infection (3)

Inflammation/Immunology (3)

Metabolic Disease (6)

Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Targets Recommended: Tissue Factor Pathway Inhibitor (TFPI) AMPK Acetyl-CoA Carboxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125848

Ginsenoside F2	Apoptosis AMPK PPAR p38 MAPK PI3K Akt GSK-3 Reactive Oxygen Species (ROS) SOD Caspase	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Ginsenoside F2 is an orally active bioactive compound that participates in the regulation of metabolism and inflammation. Ginsenoside F2 promotes the phosphorylation of *AMPK* and *ACC, binds to PPARγ, inhibits the phosphorylation of MAPK, activates the PI3K/AKT/GSK-3β* pathway, reduces GLRX expression, and regulates lipid metabolism. Ginsenoside F2 reduces ROS production and MDA levels, restores SOD activity in cells, and alleviates oxidative stress. Ginsenoside F2 induces cell apoptosis (Apoptosis) and increases the number of cleaved caspase-3-positive cells. Ginsenoside F2 reduces body weight gain, adipose tissue weight and serum lipid levels in obese mice, and activates the hepatic *AMPK* signaling pathway and the expression of antioxidant enzymes. Ginsenoside F2 alleviates atopic dermatitis in mice by inhibiting inflammation and reshaping the gut microbiota . Ginsenoside F2 is applicable to research related to insulin resistance, obesity, atopic dermatitis, liver cancer, glioblastoma and glioma .

HY-N0772

Isomangiferin 4 Publications Verification	VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative	Infection Metabolic Disease Inflammation/Immunology Cancer
Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the *AMPK/ACC* pathway, thereby facilitating fracture healing .

HY-N0853A

Alisol A 24-acetate 1 Publications Verification Alisol A 24-monoacetate; Alisol A monoacetate	AMPK Carnitine Palmitoyltransferase (CPT) Acyltransferase Fatty Acid Synthase (FASN) Acetyl-CoA Carboxylase Bcl-2 Family PPAR Nuclear Factor of activated T Cells (NFAT) PI3K Akt PKA ERK Apoptosis Autophagy	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Endocrinology
Alisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, *ACC, FAS, Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR* and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis .

HY-124609

CAD031	AMPK Acetyl-CoA Carboxylase	Neurological Disease
CAD031 is an orally active *AMPK/ACC1* signaling pathway activator and a derivative of the Alzheimer's disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer's disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice .

HY-N10612

Petasin	AMPK PPAR TRP Channel Mitochondrial Metabolism	Metabolic Disease Cancer
Petasin inhibits adipogenesis in cell 3T3-F442A with an IC₅₀ of 0.95 μM. Petasin inhibits the expression of lipid synthesis factors ACC1, FAS and SCD1 by inhibiting transcription factors PPARγ and C/EBPα, as well as targeting TRPA1 and TRPV1 channels . Petasin inhibits mitochondrial complex I, thereby inhibiting tumor growth and metastasis. Petasin activates *AMPK* signaling pathway, participating in regulation of glucose and lipid metabolism. Petasin is orally active .

HY-N3055

Pinusolide	Apoptosis AMPK Platelet-activating Factor Receptor (PAFR) Caspase	Neurological Disease Metabolic Disease Cancer
Pinusolide is an *AMPK* activator and PAF receptor antagonist. Pinusolide activates AMPK, phosphorylates *ACC, enhances IRS-1* tyrosine phosphorylation, boosts glucose uptake, and modulates insulin signaling. Pinusolide inhibits caspase-3/7 activation, intracellular calcium elevation, reactive oxygen species overproduction, lipid peroxidation, and tumor cell proliferation. Pinusolide stabilizes superoxide dismutase activity, reduces apoptotic hallmarks, induces mitochondrial pathway apoptosis, and triggers DNA fragmentation. Pinusolide can be used for the research of type 2 diabetes, neurodegenerative diseases, acute lymphoblastic leukemia, acute myeloid leukemia, and Burkitt lymphoma .

HY-N0772R

Isomangiferin (Standard)	Reference Standards VEGFR NF-κB NOD-like Receptor (NLR) AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative	Infection Metabolic Disease Inflammation/Immunology Cancer
Isomangiferin (Standard) is the analytical standard of Isomangiferin (HY-N0772). This product is intended for research and analytical applications. Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the *AMPK/ACC* pathway, thereby facilitating fracture healing.

Cat. No.	Product Name	Category	Target	Chemical Structure