18674-16-3
Chemical Structure
Alisol A 24-acetate
Synonym(s): Alisol A 24-monoacetate; Alisol A monoacetate
- CAS No.: 18674-16-3
- Formula:C32H52O6
- Molecular Weight:532.75
IUPAC Name: (3R,4S,6R)-2,4-dihydroxy-6-((5R,8S,9S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-3-oxo-2,3,4,5,6,7,8,9,10,11,12,14,15,16-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylheptan-3-yl acetate
InChIKey: WXHUQVMHWUQNTG-JSWHPQHOSA-N
SMILES: C[C@]([C@@]1(C2=C([C@H](C)C[C@H](O)[C@H](C(C)(O)C)OC(C)=O)CC1)C)(CC[C@@]3([H])C4(C)C)[C@]([C@H](C2)O)([H])[C@]3(CCC4=O)C
Biological Activity: Alisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, ACC, FAS, Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Alisol A 24-acetate | 98.0% | Alisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, ACC, FAS, Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis. | ||||||||||||||||||||
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Alisol A 24-acetate (Standard) | ≥98% | Alisol A 24-acetate (Standard) is the analytical standard of Alisol A 24-acetate. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Zeng L, et al. Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells. Cell Physiol Biochem. 2016;40(3-4):453-464. [Content Brief]
- [2]. Wang C, et al. Alisol A 24-Acetate and Alisol B 23-Acetate Induced Autophagy Mediates Apoptosis and Nephrotoxicity in Human Renal Proximal Tubular Cells. Front Pharmacol. 2017;8:172. Published 2017 Mar 31. [Content Brief]
- [3]. Lou HX, et al. Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes. BMC Complement Med Ther. 2021;21(1):128. Published 2021 Apr 22. [Content Brief]
- [4]. Lu T, et al. Neuroprotective effects of alisol A 24-acetate on cerebral ischaemia-reperfusion injury are mediated by regulating the PI3K/AKT pathway. J Neuroinflammation. 2022;19(1):37. Published 2022 Feb 7. [Content Brief]
- [5]. Liang LJ, et al. Alisol A 24-Acetate combats Methicillin-Resistant Staphylococcus aureus infection by targeting the mevalonate biosynthesis. Biochem Pharmacol. 2025;233:116766. [Content Brief]
- [6]. Kim KJ, et al. The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis. Int J Endocrinol. 2015;2015:132436. [Content Brief]
