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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
Caco-2 cell layers
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "Caco-2 cell layers" in MCE Product Catalog:
1
Target:
Research Areas:
THIP (Gaboxadol) is a blood-brain barrier-penetrant, orally active selective GABAA receptor agonist. THIP exhibits EC50 values of 33 μM and 130 μM for α4β2δ and α4β1δ receptors, respectively. THIP activates extrasynaptic GABAA receptors to produce tonic inhibition and inhibits GABAergic interneurons to cause disinhibition. THIP is used in research on insomnia, sleep disorders, and addictive behaviors .
Synonyms: 1,2-Didecanoyl-sn-glycero-3-phosphocholine
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1,2-Didecanoyl PC (1,2-Didecanoyl-sn-glycero-3-phosphocholine) is an orally effective medium-chain saturated phospholipid with well-defined P-gp inhibitory activity and membrane-modulating functions. As a functional excipient/absorption enhancer, 1,2-Didecanoyl PC is particularly suitable for oral formulations of P-gp substrates (e.g., Ritonavir (HY-90001)) .
Cat. No.: HY-10232S
CAS No.: 2748778-97-2
Synonyms: Gaboxadol-d4
Research Areas:
THIP-d4 (Gaboxadol-d4) is the deuterated-labeled THIP (HY-10232). THIP (Gaboxadol) is a blood-brain barrier-penetrant, orally active selective GABAA receptor agonist. THIP exhibits EC50 values of 33 μM and 130 μM for α4β2δ and α4β1δ receptors, respectively. THIP activates extrasynaptic GABAA receptors to produce tonic inhibition and inhibits GABAergic interneurons to cause disinhibition. THIP is used in research on insomnia, sleep disorders, and addictive behaviors .
Cat. No.: HY-10232R
CAS No.: 64603-91-4
Synonyms: Gaboxadol (Standard)
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Research Areas:
THIP (Gaboxadol) Standard is the analytical standard of THIP (HY-10232). This product is intended for research and analytical applications. THIP (Gaboxadol) is a blood-brain barrier-penetrant, orally active selective GABAA receptor agonist. THIP exhibits EC50 values of 33 μM and 130 μM for α4β2δ and α4β1δ receptors, respectively. THIP activates extrasynaptic GABAA receptors to produce tonic inhibition and inhibits GABAergic interneurons to cause disinhibition. THIP is used in research on insomnia, sleep disorders, and addictive behaviors .
Cat. No.: HY-10232A
CAS No.: 65202-63-3
Synonyms: Gaboxadol (hydrobromid)
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Research Areas:
THIP (Gaboxadol) hydrobromide is a blood-brain barrier-penetrant, orally active selective GABAA receptor agonist. THIP hydrobromide exhibits EC50 values of 33 μM and 130 μM for α4β2δ and α4β1δ receptors, respectively. THIP hydrobromide activates extrasynaptic GABAA receptors to produce tonic inhibition and inhibits GABAergic interneurons to cause disinhibition. THIP hydrobromide is used in research on insomnia, sleep disorders, and addictive behaviors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
