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Results for "

Crosslinker

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Alkylator/Crosslinker (15) ADC Linker (15) ADC Payload (1) Amino Acid Derivatives (3) Apoptosis (1) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (133) Casein Kinase (1) Caspase (3) DNA/RNA Synthesis (2) Drug Derivative (1) Drug-Linker Conjugates for ADC (2) E3 Ligase Ligand-Linker Conjugates (3) Endogenous Metabolite (1) Environmental Pollutants (4) Epigenetic Reader Domain (1) Fluorescent Dye (2) Fructose-1,6-bisphosphate aldolase (1) Isotope-Labeled Compounds (5) Liposome (3) MDM-2/p53 (2) MOFs (1) Parasite (1) Peptide-Drug Conjugates (PDCs) (1) PROTAC Linkers (15) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Topoisomerase (2)
By Research Areas:	Cancer (47) Cardiovascular Disease (2) Endocrinology (3) Infection (2) Inflammation/Immunology (8) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	ADC Synthesis (1) DBCO (1) PROTAC Synthesis (3) BCN (1) Azide (7) Alkynes (1)
Oligonucleotides:	Pegylated Lipids (3)

199

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: DNA Alkylator/Crosslinker

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W019543

Disuccinimidyl suberate Crosslinker Maximum Cited Publications 14 Publications Verification	Biochemical Assay Reagents	Cancer
Disuccinimidyl suberate Crosslinker is an amine-reactive bifunctional protein crosslinker. Disuccinimidyl suberate Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-124329

BS3 Crosslinker 1 Publications Verification	Biochemical Assay Reagents	Cancer
BS3 Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-114697

DSG Crosslinker 4 Publications Verification Disuccinimidyl glutarate	Biochemical Assay Reagents	Inflammation/Immunology
DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-D0975

Sulfo-SMCC sodium 5 Publications Verification	ADC Linker	Cancer
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

HY-118759

DSP Crosslinker 2 Publications Verification	Biochemical Assay Reagents	Inflammation/Immunology
DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-42360

SMCC 1 Publications Verification	ADC Linker	Cancer
SMCC is a protein crosslinker. SMCC contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses .

HY-124329A

*BS3 Crosslinker* disodium** 1 Publications Verification	Biochemical Assay Reagents	Cancer
BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-126349

DTSSP Crosslinker	ADC Linker	Others
DTSSP Crosslinker is a crosslinker reactive with primary amines. DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-100216

SPDP 5 Publications Verification SPDP Crosslinker; Py-ds-Prp-OSu	ADC Linker	Cancer
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) .

HY-130458

EGNHS 5 Publications Verification EGS Crosslinker	PROTAC Linkers	Cancer
EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-128925

AMAS 1 Publications Verification	ADC Linker	Cancer
AMAS is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.

HY-157414

Azide-A-DSBSO crosslinker	Biochemical Assay Reagents	Others
Azide-A-DSBSO crosslinker is a mass spectrometry (MS) cleavable, membrane permeable, homobifunctional, azide-labeled, acid-cleavable crosslinking peptide. Azide-A-DSBSO crosslinker crosslinks proteins via NHS ester reaction with lysine residues. Azide-A-DSBSO crosslinker can be used to study protein-protein interactions by cross-linking mass spectrometry (XL-MS) ^{[1] .}

HY-123740

Disuccinimidyl sulfoxide DSSO	Biochemical Assay Reagents	Others
Disuccinimidyl sulfoxide (DSSO) is a sulfoxide-containing crosslinker targeting amino groups that can be cleaved by MS, and it is suitable for model peptides, proteins, and multisubunit protein complexes. Disuccinimidyl sulfoxide contains two symmetric collision-induced dissociation (CID)-cleavable sites, enabling the identification of DSSO-crosslinked peptides based on different fragmentation patterns .

HY-W011541

SIA Crosslinker Iodoacetic acid N-hydroxysuccinimide ester; N-Succinimidyl Iodoacetate	ADC Linker	Cancer
SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-111434A

N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride UAA Crosslinker 1 hydrochloride	Amino Acid Derivatives	Cancer
N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride (UAA crosslinker 1 hydrochloride) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research .

HY-W123005

Dimethyl pimelimidate dihydrochloride 1 Publications Verification	Biochemical Assay Reagents	Others
Dimethyl pimelimidate dihydrochloride is a bifunctional imidoester protein-protein crosslinker used in chromatin immunoprecipitation (ChIP) assays .

HY-W332335

Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium	Biochemical Assay Reagents	Others
Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium is a protein crosslinker, and is a biotinylation reagentcan for labeling cell surface proteins .

HY-174892

Biotin-PEG5-NHS ester	Biochemical Assay Reagents	Others
Biotin-PEG5-NHS ester is a heterobifunctional crosslinker as well as a polyethylene glycol-containing bioconjugation reagent. Biotin-PEG5-NHS ester is widely used in scientific research fields such as the construction of highly sensitive biosensors, the development of targeted drug delivery systems (e.g., liposome modification), immunofluorescence imaging, and protein affinity purification, and serves as an important tool for achieving precise labeling and functionalization of biomolecules .

HY-P3159

VPM peptide	Biochemical Assay Reagents	Others
VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel .

HY-W041994

GMBS	Fructose-1,6-bisphosphate aldolase Biochemical Assay Reagents	Cancer
GMBS is a heterobifunctional crosslinker targeting primary amines and sulfhydryl groups. GMBS can be used for chemical crosslinking of proteins and crosslinking mass spectrometry (CXMS) to study protein folding and map interfaces between interacting proteins .

HY-107783

Sulfo-GMBS	Biochemical Assay Reagents	Others
Sulfo-GMBS is a crosslinker widely used in chemical modification and coupling reactions of proteins and peptides. Among amine-thiol crosslinkers, Sulfo-GMBS generates the largest number of crosslinks and covers most of the crosslinks identified by AMAS and GMBS .

HY-150014

AMT-NHS	Others	Others
AMT-NHS is an RNA-protein crosslinker. AMT-NHS is composed of a psoralen derivative and an N-hydroxysuccinimide ester group which react with RNA bases and primary amines of protein, respectively. AMT-NHS can penetrate into living yeast cells and crosslink Cbf5 to H/ACA snoRNAs with high specificity. AMT-NHS induces different crosslinking patterns and targets both single- and double-stranded regions of RNA. AMT-NHS can be used for capturing diverse RNA-protein interactions in cells .

HY-124318

SMPH Crosslinker	PROTAC Linkers	Cancer
SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-111434

N6-[(2-Azidoethoxy)carbonyl]-L-lysine UAA Crosslinker 1	Amino Acid Derivatives	Cancer
N6-[(2-Azidoethoxy) carbonyl]-L-lysine (UAA crosslinker 1) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy) carbonyl]-L-lysine mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy) carbonyl]-L-lysine is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research .

HY-168937

HS-PEG2000-NH2 hydrochloride	PROTAC Linkers	Others
HS-PEG2000-NH2 hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .

HY-120937

DC4 Crosslinker	Biochemical Assay Reagents	Others
DC4 Crosslinker is a stable crosslinking reagent with improved activity and solubility. DC4 Crosslinker is labile cleavable with collision-induced dissociation (CID), that will be fragmented into four rearrange products containing mobilized protons .

HY-145485

HS-PEG3400-SH	PROTAC Linkers	Others
HS-PEG3400-SH, a linear homobifunctional PEG, is a cross-linker. HS-PEG-SH can be used for drug delivery and preparation of PEG hydrogels .

HY-126503

trans-Sulfo-SMCC	ADC Linker	Cancer
trans-Sulfo-SMCC is a non-cleavable and membrane permeable ADC crosslinker.

HY-134853

2-(Boc-amino)ethanethiol	Biochemical Assay Reagents	Cancer
2-(Boc-amino)ethanethiol (compound 35) is a bifunctional cross-linker that can be used in the synthesis of bifunctional azobenzene glycoconjugates .

HY-W017588

N-(2-Hydroxyethyl)maleimide	Biochemical Assay Reagents	Others
N-(2-Hydroxyethyl)maleimide is a cross-linker. N-(2-Hydroxyethyl)maleimide is used for chemical synthesis .

HY-117080

Sulfo-EGS	Biochemical Assay Reagents	Others
Sulfo-EGS is a homobifunctional, amine-reactive chemical crosslinker. Sulfo-EGS is used to study protein-protein or protein-peptide interactions, which can determine the spatial proximity of amino acid residues in a protein complex, without relying on standards .

HY-W1048851B

4-Arm-PEG10000-Maleimide 4-Arm-PEG10000-Mal	Biochemical Assay Reagents	Others
4-Arm-PEG10000-Maleimide (4-Arm-PEG10000-Mal) is a four-arm star-shaped multifunctional PEG crosslinker with an average molecular weight of 10 kDa and maleimide terminal groups. 4-Arm-PEG10000-Maleimide efficiently conjugates biomolecules via thiol-Michael reaction, and is widely used in protein modification, antibody-drug conjugation and biomaterial preparation .

HY-135066

Triallyl pentaerythritol Pentaerythritol triallyl ether	Biochemical Assay Reagents	Others
Triallyl pentaerythritol (PEATA), a crosslinker, decreases the protein rejection compared to membranes functionalized with MBAA or without any crosslinker .

HY-W104848

4-Maleimidobenzoic acid	Biochemical Assay Reagents	Others
4-Maleimidobenzoic acid is a protein crosslinker. 4-Maleimidobenzoic acid can be used to synthesis maleimidobenzoyl spacers .

HY-168940

NH2-PEG1100-COOH	Biochemical Assay Reagents	Others
NH2-PEG-COOH (Mn 1100) is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .

HY-140339

ANB-NOS	Biochemical Assay Reagents	Others Cancer
ANB-NOS is a heterobifunctional crosslinker with lipophilic, uncharged properties suitable for intracellular conjugation. ANB-NOS contains an amine-reactive Nhydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide. ANB-NOS can be used for the research of fibrosarcoma and mammary adenocarcinoma .

HY-W096122

*DTSSP Crosslinker* disodium**	Biochemical Assay Reagents	Others
DTSSP Crosslinker disodium is a protein cross-linker containing a disulfide bond. DTSSP Crosslinker disodium can react with sidechains of amino acids that are within close proximity .

HY-175419

TBIA trans bis-Isatoic anhydride	DNA/RNA Synthesis	Cancer
TBIA (trans bis-isatoic anhydride) is a covalent RNA crosslinker. TBIA selectively induces RNA tertiary interactions (e.g., multi-helix junctions, loop-helix packing). TBIA is promising for research of RNA higher-order structure and disease-associated RNAs (e.g., KRAS-mutant RNAs) .

HY-W123009

Sulfo-KMUS sodium salt 11-Maleimidoundecanoic acid sulfo-N-succinimidyl ester sodium salt	Biochemical Assay Reagents	Others
Sulfo-KMUS (sodium salt) acts as a crosslinker .

HY-129377

Sulfo-SPP	ADC Linker	Cancer
Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.

HY-136772

Pomalidomide-PEG1-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Others
Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand .

HY-126495

Sulfo-LC-SPDP	ADC Linker	Cancer
Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-168937D

HS-PEG3500-NH2 hydrochloride	PROTAC Linkers	Others
HS-PEG-NH2 (Mn 3500) hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels .

HY-168939A

Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 2000)	Biochemical Assay Reagents	Others
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 2000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .

HY-171145

ATP-ArN3	Biochemical Assay Reagents	Others
ATP-ArN3 is a UV-activatable ATP-crosslinker analog. ATP-ArN3 relys on UV irradiation to activate the aryl azide (ArN3) crosslinking group and conjugate substrate to kinases and associated proteins .

HY-130547A

BS2G Crosslinker	DNA Alkylator/Crosslinker	Cancer
BS2G Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-130547

*BS2G Crosslinker* disodium**	DNA Alkylator/Crosslinker	Cancer
BS2G Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-119523

Disuccinimidyl sebacate 2 Publications Verification DSSeb; Sebacic acid bis N-succinimidyl ester	Biochemical Assay Reagents	Others
Disuccinimidyl sebacate (DSSeb) is a cross-linker that can be used in the synthesis of the intermolecular cross-linked peptides .

HY-172384

Glycerol ethoxylate	Biochemical Assay Reagents	Others
Glycerol ethoxylate is a crosslinker for polyesters and polyester ethers. Glycerol ethoxylate can be used as an ignition improver .

Cat. No.	Product Name	Type

HY-D2396

Sulfo SMCC R-phycoerythrin Sulfo SMCC R-PE	Fluorescent Dye
Sulfo SMCC R-phycoerythrin is a conjugate composed of the protein crosslinker SMCC (HY-42360) and R-PE (R-Phycoerythrin) (HY-D0988) that can be used to label proteins to make them carry red fluorescence. Among them, SMCC is able to engage antigen-coupled spleen cells to induce antigen-specific immune responses .

HY-D2956

BC-GLA-NHS

CLIP-GLA-NHS

Fluorescent Dye

BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .

HY-D3279

SMCC-PE	Fluorescent Dye
SMCC-PE is a dipalmitoylphosphatidylethanolamine derivative modified with the heterobifunctional crosslinker SMCC. SMCC-PE is an intermediate formed by conjugating the SMCC linker with R-phycoerythrin for antibody conjugation .

HY-42360G

SMCC

Fluorescent Dye

SMCC (GMP) is the GMP level of SMCC (HY-42360). GMP guidelines are used to produce SMCC (HY-42360) (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. SMCC (GMP) is a protein crosslinker. SMCC (GMP) contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.

HY-D3240

Photoactive NTR probe

Fluorescent Dye

Photoactive NTR probe (Compound 1) is a covalent crosslinker and Fluorescent indicator targeting Nitroreductase. The Photoactive NTR probe undergoes a sequential activation process: it is first activated via nitroreductase-mediated nitro-to-amino conversion, and then forms a fluorescent product upon photoactivation. The Photoactive NTR probe can form covalent adducts with the side chains of cysteine, tyrosine, lysine and histidine in adjacent proteins to reduce fluorophore diffusion. The Photoactive NTR probe enables super-resolution (STORM) imaging of active mitochondrial nitroreductase microdomains in living cells .

Cat. No.	Product Name	Target	Research Area

HY-P3159

VPM peptide	Biochemical Assay Reagents	Others
VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-P10765

DTS-108	Peptide-Drug Conjugates (PDCs) Topoisomerase	Cancer
DTS-108 is a prodrug of SN38 (HY-13704) (a Topoisomerase I inhibitor). DTS-108 is a conjugate generated by linking SN38 to a human oligopeptide via an esterase sensitive cross-linker. DTS-108 exhibits anti-tumor activity against colorectal, lung, and mammary cancer .

HY-P11349

TG-Gln	Biochemical Assay Reagents	Others
TG-Gln (a glutamine donor peptide with the sequence H-NQEQVSPLERCG-NH₂) is a substrate-type crosslinker targeting activated coagulation transglutaminase XIII (FXIIIa). TG-Gln is promising for research of angiogenesis induction, cartilage repair, and wound healing .

HY-P3159A

VPM peptide TFA	Biochemical Assay Reagents	Others
VPM peptide TFA is a dithiol protease-cleavable peptide cross-linker. VPM peptide TFA can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel .

HY-P11661

DC-peptoid-1	Epigenetic Reader Domain	Inflammation/Immunology
DC-peptoid-1 is a specific binder and crosslinker targeting the phosphorylated Brd4 PDID domain, with a dissociation constant (K_d) of approximately 50-100 μM for human-derived targets. DC-peptoid-1 only binds to phosphorylated PDID and fails to recognize the non-phosphorylated form or other domains (such as Brd4 598-785). DC-peptoid-1 effectively crosslinks with the target protein both in solution and cell lysates. It can successfully capture phosphorylated PDID from complex systems via immobilization, without binding to bacterial-derived non-phosphorylated proteins or other non-specific phosphoproteins. DC-peptoid-1 has the potential to serve as a phosphoprotein-specific antibody substitute for applications such as immunoaffinity purification .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113033

Pentosidine	Structural Classification Natural Products Disease markers Endogenous metabolite Source Classification	Others Biochemical Assay Reagents
Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins . Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases .

Cat. No.	Product Name	Chemical Structure

HY-118759S

*DSP Crosslinker-d8*
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker (HY-118759). DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-W705390

*Disuccinimidyl suberate Crosslinker-d4*
Disuccinimidyl suberate Crosslinker-d₄ is the deuterium labeled Disuccinimidyl suberate Crosslinker (HY-W019543). Disuccinimidyl suberate Crosslinker is an amine-reactive bifunctional protein crosslinker. Disuccinimidyl suberate Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-114697S

*DSG Crosslinker-d4*
DSG Crosslinker-d₄ (Disuccinimidyl glutarate-d₄) is the deuterium labeled DSG Crosslinker (HY-114697). DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-W710827

N,N'-Methylenebisacrylamide-d6

N,N'-Methylenebisacrylamide-d₆ is the deuterium labeled N,N'-Methylenebisacrylamide (HY-D0848). N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel .

HY-124329AS

*BS3 Crosslinker-d4 disodium*
BS3 Crosslinker-d₄ disodium is the deuterium labeled BS3 Crosslinker. BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-130547S

*BS2G Crosslinker-d4 disodium*
BS2G Crosslinker-d₄ disodium is the deuterium labeled BS2G Crosslinker disodium (HY-130547). BS2G Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

Cat. No.	Product Name		Classification

HY-130435

DBCO-PEG4-amine		DBCO PROTAC Synthesis ADC Synthesis
DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker) . DBCO-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-111434A

N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride UAA Crosslinker 1 hydrochloride		Azide
N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride (UAA crosslinker 1 hydrochloride) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research .

HY-W879045

Endo-BCN-PEG5-amine Endo-BCN-PEG5-NH2		BCN
Endo-BCN-PEG5-amine (Endo-BCN-PEG5-NH2) is a click chemistry crosslinker reagent. The BCN groupis very reactive with azide-tagged molecules. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc .

HY-111434

N6-[(2-Azidoethoxy)carbonyl]-L-lysine UAA Crosslinker 1		Azide
N6-[(2-Azidoethoxy) carbonyl]-L-lysine (UAA crosslinker 1) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy) carbonyl]-L-lysine mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy) carbonyl]-L-lysine is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research .

HY-140339

ANB-NOS		PROTAC Synthesis Azide
ANB-NOS is a heterobifunctional crosslinker with lipophilic, uncharged properties suitable for intracellular conjugation. ANB-NOS contains an amine-reactive Nhydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide. ANB-NOS can be used for the research of fibrosarcoma and mammary adenocarcinoma .

HY-151792

Pomalidomid-C6-PEG3-butyl-N3		PROTAC Synthesis Azide
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a crosslinker-E3 ligase ligand conjugate, which be used in click reactive protein degrader building block for PROTAC research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151791

(S,R,S)-AHPC-C6-PEG3-butyl-N3		Azide
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate . (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140051

N-Boc-aminoxy-PEG3-propargyl t-Boc-aminooxy-PEG3-Propargyl		Alkynes
N-Boc-aminoxy-PEG3-propargyl is a crosslinker containing a propargyl group and a t-Boc-aminooxy group. N-Boc-aminoxy-PEG3-propargyl can be used in the synthesis of ADC .

HY-103700A

Azide-phenylalanine hydrochloride UAA Crosslinker 2		Azide
Azide-phenylalanine hydrochloride is a phenylalanine derivative. Azide-phenylalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W457953

tert-Butyl N-(4-azidobutyl)carbamate		Azide
tert-Butyl N-(4-azidobutyl)carbamate is N-Boc protected crosslinker. tert-Butyl N-(4-azidobutyl)carbamate can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Cat. No.	Product Name		Classification

HY-166648

DSPE-PEG2000-Maleimide sodium (purity>99%) 1 Publications Verification		Pegylated Lipids
DSPE-PEG2000-Maleimide sodium (purity>99%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>99%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>99%) is applicable to research on drug delivery .

HY-W440896

DSPE-PEG2000-SH		Pegylated Lipids
DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .

HY-166648A

DSPE-PEG-Maleimide ammonium (MW 2000) 1 Publications Verification		Pegylated Lipids
DSPE-PEG-Maleimide ammonium (MW 2000) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG-Maleimide ammonium (MW 2000) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG (2000)-RGD. DSPE-PEG-Maleimide ammonium (MW 2000) is applicable to research on drug delivery .

Targets Recommended: DNA Alkylator/Crosslinker

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-42360G

SMCC	ADC Linker	Inflammation/Immunology Cancer
SMCC (GMP) is the GMP level of SMCC (HY-42360). GMP guidelines are used to produce SMCC (HY-42360) (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. SMCC (GMP) is a protein crosslinker. SMCC (GMP) contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.

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Fluorescent Dye

Biochemical Assay Reagents

Peptides

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Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

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