N,N'-Methylenebisacrylamide
Based on 2 publication(s) in Google Scholar
N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel.
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- Purity: 99.98%
- CAS No.: 110-26-9
- 화학식: C7H10N2O2
- 분자량:154.17
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보관:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) N,N'-Methylenebisacrylamide
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Biological Activity
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Caspase-3 |
N,N'-Methylenebisacrylamide (30 mg/kg; p.o.; gestational days 6 to 17) reduces mean fetal body weight and increases the proportion of anatomical variations in Swiss mice[2].
N,N'-Methylenebisacrylamide (3 mg/kg; p.o.; daily; 4 weeks) causes severe histopathological changes, fibrosis, and glycogen depletion in testicular tissue in male Swiss albino mice[4].
N,N'-Methylenebisacrylamide (3 mg/kg; p.o.; daily; 4 weeks) induces DNA destruction in the testis of adult rats[5].
N,N'-Methylenebisacrylamide (50-200 mg/kg; p.o.; single) causes dose-dependent changes in sperm abnormality rate and sperm count in male ddY strain mice[6].
N,N'-Methylenebisacrylamide (12.5-200 mg/kg; p.o.; twice a week; 3-12 weeks) reduces the body weights, and the numbers of erythrocytes, leucocytes, platelets, reticulocytes, and bone marrow cells in the blood of both mice and rats, with more significant effects in mice[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss albino mice (Mus musculus), weighing 25-30 g, testis damage model induced by N,N'-Methylenebisacrylamide[4]
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Dosage:3 mg/kg
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Administration:Oral gavage (p.o.), daily, 4 weeks
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Result:Induced an increase in Caspase-3 expression in the testis.
Reduced the levels of albumin, IgG, and antitrypsin.
Altered blood protein fractions.
Increased the number of white blood cells and neutrophils.
Decreased the levels of lymphocytes, red blood cells, and hemoglobin.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 110-26-9
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Appearance Solid
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분자량 154.17
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화학식 C7H10N2O2
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Color White to off-white
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SMILES
C=CC(NCNC(C=C)=O)=O
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Synonyms
Bisacrylamide; MBA; Methylenebisacrylamide; N,N-Methylenebisacrylamide
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (2)
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Journal Impact Factor
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Most Recent
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J Control Release
Nano-immunomodulators co-activate immunogenic cell death and the cGAS-STING pathway for breast cancer immunotherapy. [Abstract]2026 Jun 10:394:114913. PMID: 41962772 -
용액&용해도
DMSO : 25 mg/mL (162.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
References
[1]. Atia MM, et al. Nanocurcumin and curcumin prevent N, N'-methylenebisacrylamide-induced liver damage and promotion of hepatic cancer cell growth. Sci Rep. 2022 May 18;12(1):8319. [Content Brief]
[2]. George JD, et al. Evaluation of the developmental toxicity of methacrylamide and N,N'-methylenebisacrylamide in Swiss mice. Toxicol Sci. 1998 Nov;46(1):124-33. [Content Brief]
[3]. de Souza Pereira R. Comparison of biochemical effects produced by calcium ions and by monomers of polyacrylamide (acrylamide and bisacrylamide) on strains of Saccharomyces cerevisiae used for production of chiral synthons. Mol Cell Biochem. 1998 Jan;178(1-2):33-40. [Content Brief]
[5]. Atia MM, et al. Rehabilitation of N, N'-methylenebisacrylamide-induced DNA destruction in the testis of adult rats by adipose-derived mesenchymal stem cells and conditional medium. Heliyon. 2024 Nov 14;10(23):e40380. [Content Brief]
[6]. Sakamoto J, et al. Effects of N,N'-methylene-bis-acrylamide (MBA) on mouse germ cells--sperm count and morphology, and testicular pathology. Arch Toxicol. 1988 Aug;62(1):54-9. [Content Brief]
[7]. Hashimoto K, et al. Anemia and porphyria caused by N,N'-methylene-bis-acrylamide (MBA) in mice and rats. Arch Toxicol. 1982 May;50(1):47-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4863 mL | 32.4317 mL | 64.8635 mL | 162.1587 mL |
| 5 mM | 1.2973 mL | 6.4863 mL | 12.9727 mL | 32.4317 mL | |
| 10 mM | 0.6486 mL | 3.2432 mL | 6.4863 mL | 16.2159 mL | |
| 15 mM | 0.4324 mL | 2.1621 mL | 4.3242 mL | 10.8106 mL | |
| 20 mM | 0.3243 mL | 1.6216 mL | 3.2432 mL | 8.1079 mL | |
| 25 mM | 0.2595 mL | 1.2973 mL | 2.5945 mL | 6.4863 mL | |
| 30 mM | 0.2162 mL | 1.0811 mL | 2.1621 mL | 5.4053 mL | |
| 40 mM | 0.1622 mL | 0.8108 mL | 1.6216 mL | 4.0540 mL | |
| 50 mM | 0.1297 mL | 0.6486 mL | 1.2973 mL | 3.2432 mL | |
| 60 mM | 0.1081 mL | 0.5405 mL | 1.0811 mL | 2.7026 mL | |
| 80 mM | 0.0811 mL | 0.4054 mL | 0.8108 mL | 2.0270 mL | |
| 100 mM | 0.0649 mL | 0.3243 mL | 0.6486 mL | 1.6216 mL |
N,N'-Methylenebisacrylamide Related Classifications
HY-D0848 Related Classifications
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