1 Result for "

Demethyl-Coclaurine (Standard)

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Demethyl-Coclaurine (Standard)" in MCE Product Catalog:

Higenamine (Standard)
Higenamine (Standard)
0 Images
Cat. No.: HY-N2037R
CAS No.: 5843-65-2
Synonyms: NorCoclaurine (Standard); Demethyl-Coclaurine (Standard)
Category:  

Alkaloids Ranunculaceae Phenols Polyphenols  Aconitum carmichaeli Debx. Plants Isoquinoline Alkaloids

Target:  

Reference Standards MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis

Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
loading...
    loading...
View All Sizes
Assay Types