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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
E3 Ligase Parkin
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "E3 Ligase Parkin" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-145816A
Research Areas:
JPS016 TFA is a class I histone deacetylase (HDAC) PROTAC inhibitor. JPS016 TFA recruits the VHL E3 ligase (Ligands for E3 Ligase) to mediate the ubiquitination and proteasomal degradation of HDAC1, HDAC2 and HDAC3. JPS016 TFA reduces the viability of colon cancer cells and induces Apoptosis. JPS016 TFA activates the PINK1/Parkin mitochondrial Autophagy pathway, enhances cardiomyocyte viability, alleviates mitochondrial damage, and reduces mitochondrial ROS production in cells. JPS016 TFA is applicable to research related to colon cancer and sepsis cardiomyopathy .
Cat. No.: HY-169329
Target:
Research Areas:
BIO-2007817 is a Parkin positive allosteric modulators (PAMs). BIO-2007817 enhances the activity of wildtype Parkin. BIO-2007817 stimulates Parkin (an E3 ligase)autoubiquitination and induces the appearance of monoubiquitinated forms of Miro1 (EC50: 0.17 μM) .
Cat. No.: HY-145816
CAS No.: 2669785-77-5
Research Areas:
JPS016 is a class I histone deacetylase (HDAC) PROTAC inhibitor. JPS016 recruits the VHL E3 ligase (Ligands for E3 Ligase) to mediate the ubiquitination and proteasomal degradation of HDAC1, HDAC2 and HDAC3. JPS016 reduces the viability of colon cancer cells and induces Apoptosis. JPS016 activates the PINK1/Parkin mitochondrial Autophagy pathway, enhances cardiomyocyte viability, alleviates mitochondrial damage, and reduces mitochondrial ROS production in cells. JPS016 is applicable to research related to colon cancer and sepsis cardiomyopathy .
Cat. No.: HY-177324
CAS No.: 2163817-03-4
Target:
Research Areas:
Antibacterial agent 290 (Compound YY), a sulfonamide derivative, is an antibacterial agent. Antibacterial agent 290 has antiproliferative activity against a variety of tumor cells. Antibacterial agent 290 significantly activates the E3 Ligase Parkin auto-ubiquitinvlation with an EC50 of 0.4 μM. Antibacterial agent 290 can used for synthesis of building blocks for various supramolecular structures such as metal-organic skeletons and coordination polymers. Antibacterial agent 290 can be used for cancers, neurology disorders and infections research .
Cat. No.: HY-P702810
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKN; Parkinson Juvenile Disease Protein 2; Prev. PARK2; Parkinson Protein 2 E3 Ubiquitin Protein Ligase; E3 Ubiquitin-Protein Ligase Parkin; Truncated Parkin Variant SV3,8,9DEL; Parkin; Truncated Parkin Variant SV4,8DEL; AR-JP; Truncated Parkin Variant S
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P702806
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRKN; Parkinson Juvenile Disease Protein 2; Prev. PARK2; Parkinson Protein 2 E3 Ubiquitin Protein Ligase; E3 Ubiquitin-Protein Ligase Parkin; Truncated Parkin Variant SV3,8,9DEL; Parkin; Truncated Parkin Variant SV4,8DEL; AR-JP; Truncated Parkin Variant S
Species:
Human
Source:
E. coli
Cat. No.: HY-P702807
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKN; Parkinson Juvenile Disease Protein 2; Prev. PARK2; Parkinson Protein 2 E3 Ubiquitin Protein Ligase; E3 Ubiquitin-Protein Ligase Parkin; Truncated Parkin Variant SV3,8,9DEL; Parkin; Truncated Parkin Variant SV4,8DEL; AR-JP; Truncated Parkin Variant S
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
