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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
F 16
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "F 16" in MCE Product Catalog:
Research Areas:
F16 is a mitochondrial permeability transition pore (PTP) modulator with an EC50 of 30 μM in mice. F16 promotes PTP opening, accumulates in cancer cell mitochondria, and induces mitochondrial depolarization, swelling, cristae disruption, outer membrane rupture, ATP depletion, reactive oxygen species (ROS) production, cytochrome c release and mitochondrial uncoupling. F16 induces cell cycle arrest at the G1 (occasionally G2) phase, reduces the phosphotyrosine content of Neu, as well as the levels of phosphorylated PKB/Akt and phosphorylated MAP kinase, downregulates the protein expression levels of Neu and PKB, triggers apoptosis in cells with moderate Bcl-2 expression, and induces necrosis in cells with overexpressed Bcl-2. F16 can be used in research related to breast cancer and gastric cancer .
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1 Cited Publications
Cat. No.: HY-P73634
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SNAP25; SEC9; Prev. SNAP; Synaptosomal-Associated Protein, 25kDa; SNAP-25; SUP; Synaptosomal-Associated Protein 25; Synaptosomal-Associated 25 KDa Protein; DJ1068F16.2; Synaptosome Associated Protein 25kDa; BA416N4.2; Super Protein; RIC-4; DEE117; RIC4; C
Species:
Human
Source:
E. coli
Target:
Research Areas:
PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability .
Cat. No.: HY-171544
Synonyms: AGS-16M8F
Cat. No.: HY-P990315
Synonyms: AGS-16C
Target:
Research Areas:
Target:
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Cyclosiversioside F 16,25-diacetate (Compound 6), a glycoside, is an alkaline hydrolysis product of Acetyl Derivative (Compound 2) .
Cat. No.: HY-157292
CAS No.: 3002962-69-5
Research Areas:
2E-3-F16 is a anticancer agent. 2E-3-F16 exhibits tumor cell selectivity between NCI-H446 cancer cells and HBE cells. 2E-3-F16 enhances the sensitivity of A549 cells to Cisplatin (HY-17394) .
Cat. No.: HY-100395R
CAS No.: 36098-33-6
Target:
Reference Standards Mitochondrial Metabolism Reactive Oxygen Species (ROS) Akt p38 MAPK Bcl-2 Family Apoptosis
Research Areas:
F16 (Standard) is the analytical standard of F16 (HY-100395). This product is intended for research and analytical applications. F16 is a mitochondrial permeability transition pore (PTP) modulator with an EC50 of 30 μM in mice. F16 promotes PTP opening, accumulates in cancer cell mitochondria, and induces mitochondrial depolarization, swelling, cristae disruption, outer membrane rupture, ATP depletion, reactive oxygen species (ROS) production, cytochrome c release and mitochondrial uncoupling. F16 induces cell cycle arrest at the G1 (occasionally G2) phase, reduces the phosphotyrosine content of Neu, as well as the levels of phosphorylated PKB/Akt and phosphorylated MAP kinase, downregulates the protein expression levels of Neu and PKB, triggers apoptosis in cells with moderate Bcl-2 expression, and induces necrosis in cells with overexpressed Bcl-2. F16 can be used in research related to breast cancer and gastric cancer .
Cat. No.: HY-149002
CAS No.: 3031403-77-4
Target:
Research Areas:
Topoisomerase I/II inhibitor 4 (compound F16) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase I/II inhibitor 4 inhibits cell proliferation, invasion and migration and induces apoptosis. Topoisomerase I/II inhibitor 4 can be used for liver cancer research .
Cat. No.: HY-W110066
CAS No.: 14916-87-1
Synonyms: F16CuPc (purified by sublimation)
Copper hexadecafluorophthalocyanine (F16CuPc (purified by sublimation)) is a metal-organic framework (MOF).
Cat. No.: HY-P992067
Research Areas:
Cat. No.: HY-184280
CAS No.: 3128226-38-7
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Anticancer agent 329 is a mitochondria-targeted Podophyllotoxin (HY-15552) derivative conjugated with F16 (HY-100395), and also acts as an anticancer agent. Anticancer agent 329 accumulates in mitochondria and induces Apoptosis in a concentration-dependent manner. Anticancer agent 329 can be used in the research of liver cancer, colorectal cancer, non-small cell lung cancer and breast cancer .
Cat. No.: HY-P81519
Synonyms: 6-bisphosphatase 1 antibody;
6-bisphosphate 1-phosphohydrolase 1 antibody;
D fructose 1 6 bisphosphate 1 phosphohydrolase 1 antibody;
D-fructose-1 antibody;
EC 3.1.3.11 antibody;
F16P1_HUMAN antibody;
FBP antibody;
FBP 1 antibody;
FBP1 antibody;
FBPase 1 antibody;
Fructose 1 6 bisphosphatase 1 antibody;
Fructose bisphosphatase 1 antibody;
Fructose-1 antibody;
Growth inhibiting protein 17 antibody;
Liver fructose bisphosphatase antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
