country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184280

Copy Link Print Information

Anticancer agent 329

Anticancer agent 329 is a mitochondria-targeted Podophyllotoxin (HY-15552) derivative conjugated with F16 (HY-100395), and also acts as an anticancer agent. Anticancer agent 329 accumulates in mitochondria and induces Apoptosis in a concentration-dependent manner. Anticancer agent 329 can be used in the research of liver cancer, colorectal cancer, non-small cell lung cancer and breast cancer.

For research use only. We do not sell to patients.

CAS No.: 3128226-38-7
Formula: C₄₅H₄₇BrN₂O₉
Molecular Weight:839.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 329 Chemical Structure

CAS No.: 3128226-38-7

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Anticancer agent 329 (Compound 6d) potently inhibits the proliferation of HepG2, HCT116, A549, and MDA-MB-231 cells with IC₅₀ values of 0.66 μM, 1.10 μM, 2.00 μM, and 3.31 μM respectively, and exhibits a selectivity index of 2.29 for HepG2 cells over normal QSG-7701 hepatocytes^[1].
Anticancer agent 329 (1.2-4.8 μM; 24 h) induces apoptosis in HepG2 cells in a concentration-dependent manner, with total apoptosis rates reaching 17.79% at a 4.8 μM 24-hour treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3128226-38-7
Molecular Weight 839.77
Formula C₄₅H₄₇BrN₂O₉
SMILES

O=C(OC1)[C@@H]([C@H]1[C@H]2OC(CCCCCCC[N+]3=CC=C(/C=C/C4=CNC5=C4C=CC=C5)C=C3)=O)[C@H](C6=CC(OC)=C(OC)C(OC)=C6)C(C2=C7)=CC8=C7OCO8.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu C, et al. Synthesis of mitochondria-targeted podophyllotoxin derivatives for the imaging and antiproliferation of liver cancer. Bioorganic & medicinal chemistry letters. 2026 Jul;136:130591. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote