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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
Ferroptosis-IN-3
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "Ferroptosis-IN-3" in MCE Product Catalog:
Cat. No.: HY-149670
CAS No.: 3017222-33-9
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Ferroptosis-IN-3 (Compound 25) is a ferroptosis inhibitor. Ferroptosis-IN-3 inhibits RSL3-induced ferroptosis (EC50: 8.6 nM in HT-1080 cells). Ferroptosis-IN-3 scavenges DPPH and ABTS radicals (EC50: 3.94 and 6.3 μM respectively). Ferroptosis-IN-3 decreases lipid peroxidation .
Cat. No.: HY-175615
CAS No.: 3051815-39-2
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RSL3-NH2 is a GPX4 inhibitor and ferroptosis inducer. RSL3-NH2 triggers the iron-dependent cell death pathway associated with lipid peroxidation by inhibiting GPX4 activity. RSL3-NH2 exhibits significant cytotoxicity against colorectal cancer cells and effectively induces their ferroptosis. RSL3-NH2 can serve as a ADC payload for synthesizing antibody-drug conjugates (ADC) and be used in colorectal cancer-related research .
Cat. No.: HY-Y0172S
CAS No.: 64502-99-4
Cat. No.: HY-Y0172S2
CAS No.: 86819-59-2
Cat. No.: HY-Y0172S1
CAS No.: 1219805-92-1
Cat. No.: HY-161760
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Ferroptosis inducer-3 (compound JB3) is an oral bioactive inhibitor of RAF1, with the IC50 of 226.9 nM. Ferroptosis inducer-3 can induce ferroptosis and plays an important role in cancer research .
Cat. No.: HY-P10132
CAS No.: 847447-01-2
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Cat. No.: HY-175615A
CAS No.: 3051815-40-5
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RSL3-NH2 hydrochloride is a GPX4 inhibitor and ferroptosis inducer. RSL3-NH2 hydrochloride triggers the iron-dependent cell death pathway associated with lipid peroxidation by inhibiting GPX4 activity. RSL3-NH2 hydrochloride exhibits significant cytotoxicity against colorectal cancer cells and effectively induces their ferroptosis. RSL3-NH2 hydrochloride can serve as a ADC payload for synthesizing a ADC and be used in colorectal cancer-related research .
Cat. No.: HY-189247
PRDX3-IN-1 is an orally active antagonist targeting mitochondrial PRDX3 (Kd=0.514 μM), where PRDX3 is a marker of ferroptosis. PRDX3-IN-1 causes PRDX3 inactivation and disrupts mitochondrial redox homeostasis, inducing apoptosis, ROS accumulation, and a decrease in mitochondrial membrane potential. PRDX3-IN-1 inhibits cell migration and invasion, and downregulates NF-κB and VEGF signaling pathways. PRDX3-IN-1 can be used for research on non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
