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Fidaxomicin-resistant C. difficile

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Myxopyronin B
Myxopyronin B
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Cat. No.: HY-N21879
CAS No.: 88192-99-8
Category:  

Microorganisms Ketones, Aldehydes, Acids

Target:  

Endogenous Metabolite Bacterial DNA/RNA Synthesis

Myxopyronin B is an α-pyrone natural product derived from Myxococcus fulvus and acts as an inhibitor of the switch region of bacterial RNA polymerase (RNAP) (IC50 = 24 μM). Myxopyronin B binds to the switch region of RNA polymerase, locking the polymerase clamp into a closed conformation and thereby inhibiting transcription initiation. Myxopyronin B exhibits antibacterial activity against Staphylococcus aureus and Clostridioides difficile, inhibits the early synthesis of toxins A and B, and reduces the abundance of proteins in the branched-chain amino acid fermentation pathway. Myxopyronin B is useful for research related to bacterial infections .
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