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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
GOLPH2/GOLM1 Inhibitors
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "GOLPH2/GOLM1 Inhibitors" in MCE Product Catalog:
20
20 Cited Publications
Research Areas:
CC-885, a cereblon (CRBN) modulator, acts as a molecular glue degrader targeting GSPT1 with a Kd of 350 nM. CC-885 binds to CRBN to alter the substrate specificity of the CRL4 E3 ligase, promoting the ubiquitination and proteasomal degradation of GSPT1, BNIP3L, PLK1, CDK4, IKZF1/3, GSPT2, WIZ, CHD7, GOLM1, CK1α and ETS1. CC-885 induces apoptosis, cell cycle arrest, transcriptional downregulation and antiproliferation in cancer cells. CC-885 is applicable to research related to relapsed/refractory acute myeloid leukemia, MYC-driven tumors, metastatic castration-resistant prostate cancer, multiple myeloma, hepatocellular carcinoma, glioblastoma, VHL-deficient clear cell renal cell carcinoma and non-small cell lung cancer [1] [2] .
Cat. No.: HY-RS05592
Target:
Research Areas:
GOLM1 Human Pre-designed siRNA Set A contains three designed siRNAs for GOLM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19437
Target:
Research Areas:
Golm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Golm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25928
Target:
Research Areas:
Golm1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Golm1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P990421
Target:
Research Areas:
Cat. No.: HY-P70879
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GOLM1; FLJ23608; Prev. C9orf155; CDNA PSEC0257 Fis, Clone NT2RP3003642, Highly Similar To Golgi Phosphoprotein 2; Prev. GOLPH2; CDNA FLJ14811 Fis, Clone NT2RP4001975, Highly Similar To Golgi Phosphoprotein 2; Golgi Phosphoprotein 2; Golgi Phosphoprotein 2
Species:
Human
Source:
HEK293
Cat. No.: HY-P72209A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GOLM1; FLJ23608; Prev. C9orf155; CDNA PSEC0257 Fis, Clone NT2RP3003642, Highly Similar To Golgi Phosphoprotein 2; Prev. GOLPH2; CDNA FLJ14811 Fis, Clone NT2RP4001975, Highly Similar To Golgi Phosphoprotein 2; Golgi Phosphoprotein 2; Golgi Phosphoprotein 2
Species:
Human
Source:
E. coli
Cat. No.: HY-P72209
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GOLM1; FLJ23608; Prev. C9orf155; CDNA PSEC0257 Fis, Clone NT2RP3003642, Highly Similar To Golgi Phosphoprotein 2; Prev. GOLPH2; CDNA FLJ14811 Fis, Clone NT2RP4001975, Highly Similar To Golgi Phosphoprotein 2; Golgi Phosphoprotein 2; Golgi Phosphoprotein 2
Species:
Human
Source:
E. coli
Cat. No.: HY-101488R
CAS No.: 1010100-07-8
CC-885 (Standard) is the analytical standard of CC-885 (HY-101488). This product is intended for research and analytical applications. CC-885, a cereblon (CRBN) modulator, acts as a molecular glue degrader targeting GSPT1 with a Kd of 350 nM. CC-885 binds to CRBN to alter the substrate specificity of the CRL4 E3 ligase, promoting the ubiquitination and proteasomal degradation of GSPT1, BNIP3L, PLK1, CDK4, IKZF1/3, GSPT2, WIZ, CHD7, GOLM1, CK1α and ETS1. CC-885 induces apoptosis, cell cycle arrest, transcriptional downregulation and antiproliferation in cancer cells. CC-885 is applicable to research related to relapsed/refractory acute myeloid leukemia, MYC-driven tumors, metastatic castration-resistant prostate cancer, multiple myeloma, hepatocellular carcinoma, glioblastoma, VHL-deficient clear cell renal cell carcinoma and non-small cell lung cancer [1] [2] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
