9 Results for "

GTP disodium

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "GTP disodium" in MCE Product Catalog:

9
Guanosine triphosphate disodium
Guanosine triphosphate disodium
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9 Cited Publications
Cat. No.: HY-W010737
CAS No.: 56001-37-7
Synonyms: GTP disodium
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis

Guanosine triphosphate (GTP) disodium is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate disodium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate disodium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate disodium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate disodium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .
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2'-Deoxyguanosine 5'-monophosphate disodium
2'-Deoxyguanosine 5'-monophosphate disodium
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1 Cited Publications
Cat. No.: HY-W013159
CAS No.: 33430-61-4
Synonyms: 5′-dGMP disodium
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Nucleoside Antimetabolite/Analog

2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .
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GDP-D-mannose disodium
GDP-D-mannose disodium
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Cat. No.: HY-N7389A
CAS No.: 103301-73-1
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Drug Intermediate

GDP-D-mannose disodium consists of GDP-α-D-mannose (HY-N7389B) and GDP-β-D-mannose. GDP-α-D-mannose serves as a donor substrate for mannosyltransferases and acts as a precursor of GDP-β-L-fucose. GDP-α-D-mannose exerts competitive inhibition on GTP (with a Ki value of 14.7 μM) and non-competitive inhibition on mannose-1-P (with a Ki value of 115 μM). GDP-D-mannose disodium is metabolized to GDP-L-fucose (HY-134433) via GMDS (Gmd) and TSTA3 (WcaG) .
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2'-Deoxyguanosine 5'-monophosphate-13C10,15N5 disodium
2'-Deoxyguanosine 5'-monophosphate-13C10,15N5 disodium
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Cat. No.: HY-W013159S
Synonyms: 5′-dGMP-13C10,15N5 disodium
2'-Deoxyguanosine 5'-monophosphate- 13C10, 15N5 (dGMP- 13C10, 15N5) disodium is the 13C and 15N labeled 2'-Deoxyguanosine 5'-monophosphate disodium (HY-W013159). 2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .
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GDP-α-D-mannose disodium
GDP-α-D-mannose disodium
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Cat. No.: HY-N7389B
CAS No.: 148296-46-2
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) .
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7-Methyl-guanosine-5'-triphosphate disodium
7-Methyl-guanosine-5'-triphosphate disodium
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Cat. No.: HY-21586
CAS No.: 104809-18-9
Synonyms: m7GTP disodium
Target:  

Nucleoside Antimetabolite/Analog

Research Areas:  

Metabolic Disease

7-Methyl-guanosine-5'-triphosphate (m7GTP) disodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate disodium phosphorothioate analog is a potent cap-dependent translation inhibitor .
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TAK 044
TAK 044
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Cat. No.: HY-105168
CAS No.: 157380-72-8
Target:  

Endothelin Receptor

Research Areas:  

Cardiovascular Disease

TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .
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MRS2690 disodium
MRS2690 disodium
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Cat. No.: HY-116295A
Target:  

P2Y Receptor p38 MAPK Calcium Channel

Research Areas:  

Cardiovascular Disease

MRS2690 disodium is a selective P2Y14 receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [ 35S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease .
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2'-Deoxyguanosine 5'-monophosphate disodium (Standard)
2'-Deoxyguanosine 5'-monophosphate disodium (Standard)
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Cat. No.: HY-W013159R
CAS No.: 33430-61-4
Synonyms: 5′-dGMP disodium (Standard)
Category:  

Natural Products Endogenous metabolite

Target:  

Endogenous Metabolite Reference Standards Nucleoside Antimetabolite/Analog

2'-Deoxyguanosine 5'-monophosphate (disodium) (Standard) is the analytical standard of 2'-Deoxyguanosine 5'-monophosphate (disodium) (HY-W013159). This product is intended for research and analytical applications. 2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .
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